ID   B7Z774_HUMAN            Unreviewed;       301 AA.
AC   B7Z774;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=cDNA FLJ52874, highly similar to Pre-B-cell leukemia transcription factor 1 {ECO:0000313|EMBL:BAH13510.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH13510.1};
RN   [1] {ECO:0000313|EMBL:BAH13510.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Breast {ECO:0000313|EMBL:BAH13510.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
CC       {ECO:0000256|ARBA:ARBA00007601}.
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DR   EMBL; AK301540; BAH13510.1; -; mRNA.
DR   AlphaFoldDB; B7Z774; -.
DR   SMR; B7Z774; -.
DR   MaxQB; B7Z774; -.
DR   PeptideAtlas; B7Z774; -.
DR   ProteomicsDB; 6839; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR005542; PBX_PBC_dom.
DR   PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR   PANTHER; PTHR11850:SF89; PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 1; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF03792; PBC; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS51978; PBC; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}.
FT   DOMAIN          1..127
FT                   /note="PBC"
FT                   /evidence="ECO:0000259|PROSITE:PS51978"
FT   DOMAIN          126..189
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        128..190
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          212..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   301 AA;  33001 MW;  7A099E1AC8A99085 CRC64;
     MRLDNMLLAE GVAGPEKGGG SAAAAAAAAA SGGAGSDNSV EHSDYRAKLS QIRQIYHTEL
     EKYEQACNEF TTHVMNLLRE QSRTRPISPK EIERMVSIIH RKFSSIQMQL KQSTCEAVMI
     LRSRFLDARR KRRNFNKQAT EILNEYFYSH LSNPYPSEEA KEELAKKCGI TVSQVSNWFG
     NKRIRYKKNI GKFQEEANIY AAKTAVTATN VSAHGSQANS PSTPNSAGSS SSFNMSNSGD
     LFMSVQSLNG DSYQGAQVGA NVQSQVDTLR HVISQTGGYS DGLAASQMYS PQGISEIART
     Y
//