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B7Z731

- B7Z731_HUMAN

UniProt

B7Z731 - B7Z731_HUMAN

Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

    GO - Molecular functioni

    1. glucosylceramidase activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. sphingolipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolismUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Pathology & Biotechi

    Protein family/group databases

    Allergomei8244. Hom s Glucocerebrosidase.

    PTM / Processingi

    Proteomic databases

    PRIDEiB7Z731.

    Structurei

    3D structure databases

    ProteinModelPortaliB7Z731.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 30 family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG002285.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR11069. PTHR11069. 1 hit.
    PfamiPF02055. Glyco_hydro_30. 1 hit.
    [Graphical view]
    PRINTSiPR00843. GLHYDRLASE30.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7Z731-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSSPSREE CPKPLSRVSV MAGSLTGLLL LQAVSWASGI GYNIIRVPMA    50
    SCDFSIRTYT YADTPDDFQL HNFSLPEEDT KLKIPLIHRA LQLALRPVSL 100
    LASPWTSPTW LKTNGAVNGK GSLKGQPGDI YHQTWARYFV KFLDAYAEHK 150
    LQFWAVTAEN EPSAGLLSGY PFQCLGFTPE HQRDFIARDL GPTLANSTHH 200
    NVRLLMLDDQ RLLLPHWAKV VLTDPEAAKY VHGIAVHWYL DFLAPAKATL 250
    GETHRLFPNT MLFASEACVG SKFWEQSVRL GSWDRGMQYS HSIITNLLYH 300
    VVGWTDWNLA LNPEGGPNWV RNFVDSPIIV DITKDTFYKQ PMFYHLGHFS 350
    KFIPEGSQRV GLVASQKNDL DAVALMHPDG SAVVVVLNRS SKDVPLTIKD 400
    PAVGFLETIS PGYSIHTYLW RRQ 423
    Length:423
    Mass (Da):47,535
    Last modified:March 3, 2009 - v1
    Checksum:iA4B5D6AAB39D04CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK301374 mRNA. Translation: BAH13467.1.
    UniGeneiHs.282997.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK301374 mRNA. Translation: BAH13467.1 .
    UniGenei Hs.282997.

    3D structure databases

    ProteinModelPortali B7Z731.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 8244. Hom s Glucocerebrosidase.

    Proteomic databases

    PRIDEi B7Z731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG002285.

    Miscellaneous databases

    NextBioi 35480132.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR11069. PTHR11069. 1 hit.
    Pfami PF02055. Glyco_hydro_30. 1 hit.
    [Graphical view ]
    PRINTSi PR00843. GLHYDRLASE30.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Synovial membrane tissueImported.

    Entry informationi

    Entry nameiB7Z731_HUMAN
    AccessioniPrimary (citable) accession number: B7Z731
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.