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B7Z731

- B7Z731_HUMAN

UniProt

B7Z731 - B7Z731_HUMAN

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Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

  1. glucosylceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. sphingolipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Protein family/group databases

Allergomei8244. Hom s Glucocerebrosidase.

PTM / Processingi

Proteomic databases

PRIDEiB7Z731.

Structurei

3D structure databases

ProteinModelPortaliB7Z731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG002285.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z731-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFSSPSREE CPKPLSRVSV MAGSLTGLLL LQAVSWASGI GYNIIRVPMA
60 70 80 90 100
SCDFSIRTYT YADTPDDFQL HNFSLPEEDT KLKIPLIHRA LQLALRPVSL
110 120 130 140 150
LASPWTSPTW LKTNGAVNGK GSLKGQPGDI YHQTWARYFV KFLDAYAEHK
160 170 180 190 200
LQFWAVTAEN EPSAGLLSGY PFQCLGFTPE HQRDFIARDL GPTLANSTHH
210 220 230 240 250
NVRLLMLDDQ RLLLPHWAKV VLTDPEAAKY VHGIAVHWYL DFLAPAKATL
260 270 280 290 300
GETHRLFPNT MLFASEACVG SKFWEQSVRL GSWDRGMQYS HSIITNLLYH
310 320 330 340 350
VVGWTDWNLA LNPEGGPNWV RNFVDSPIIV DITKDTFYKQ PMFYHLGHFS
360 370 380 390 400
KFIPEGSQRV GLVASQKNDL DAVALMHPDG SAVVVVLNRS SKDVPLTIKD
410 420
PAVGFLETIS PGYSIHTYLW RRQ
Length:423
Mass (Da):47,535
Last modified:March 3, 2009 - v1
Checksum:iA4B5D6AAB39D04CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301374 mRNA. Translation: BAH13467.1.
UniGeneiHs.282997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301374 mRNA. Translation: BAH13467.1 .
UniGenei Hs.282997.

3D structure databases

ProteinModelPortali B7Z731.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 8244. Hom s Glucocerebrosidase.

Proteomic databases

PRIDEi B7Z731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG002285.

Miscellaneous databases

NextBioi 35480132.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR11069. PTHR11069. 1 hit.
Pfami PF02055. Glyco_hydro_30. 1 hit.
[Graphical view ]
PRINTSi PR00843. GLHYDRLASE30.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Synovial membrane tissueImported.

Entry informationi

Entry nameiB7Z731_HUMAN
AccessioniPrimary (citable) accession number: B7Z731
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.