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Protein
Submitted name:

Lysosomal acid phosphatase

Gene

ACP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lysosomal acid phosphataseImported
Submitted name:
cDNA FLJ51107, highly similar to Lysosomal acid phosphatase (EC 3.1.3.2)Imported
Gene namesi
Name:ACP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:123. ACP2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500764495931 – 162Sequence analysisAdd BLAST132

Proteomic databases

MaxQBiB7Z6U3.
PeptideAtlasiB7Z6U3.
PRIDEiB7Z6U3.

Expressioni

Gene expression databases

BgeeiENSG00000134575.
ExpressionAtlasiB7Z6U3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256997.

Structurei

3D structure databases

ProteinModelPortaliB7Z6U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000198917.
HOVERGENiHBG106194.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z6U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT
60 70 80 90 100
YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV
110 120 130 140 150
YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR
160
QAQVTRTVEH SA
Length:162
Mass (Da):18,672
Last modified:March 3, 2009 - v1
Checksum:iB845D6E0C1DB2243
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018410 Genomic DNA. No translation available.
AK300931 mRNA. Translation: BAH13379.1.
UniGeneiHs.532492.

Genome annotation databases

EnsembliENST00000530453; ENSP00000434205; ENSG00000134575.
UCSCiuc058bce.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018410 Genomic DNA. No translation available.
AK300931 mRNA. Translation: BAH13379.1.
UniGeneiHs.532492.

3D structure databases

ProteinModelPortaliB7Z6U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256997.

Proteomic databases

MaxQBiB7Z6U3.
PeptideAtlasiB7Z6U3.
PRIDEiB7Z6U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530453; ENSP00000434205; ENSG00000134575.
UCSCiuc058bce.1. human.

Organism-specific databases

HGNCiHGNC:123. ACP2.
OpenTargetsiENSG00000134575.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000198917.
HOVERGENiHBG106194.

Miscellaneous databases

ChiTaRSiACP2. human.

Gene expression databases

BgeeiENSG00000134575.
ExpressionAtlasiB7Z6U3. baseline and differential.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z6U3_HUMAN
AccessioniPrimary (citable) accession number: B7Z6U3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.