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Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28591.

Protein family/group databases

Allergomei8244. Hom s Glucocerebrosidase.

PTM / Processingi

Proteomic databases

PRIDEiB7Z6S9.

Expressioni

Gene expression databases

GenevisibleiB7Z6S9. HS.

Interactioni

Protein-protein interaction databases

IntActiB7Z6S9. 1 interaction.
STRINGi9606.ENSP00000314508.

Structurei

3D structure databases

ProteinModelPortaliB7Z6S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000270031.
HOVERGENiHBG002285.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z6S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRLFSNPG PAPTPQGCFS RGCGWSGCIL PSESYCAGPQ SPVPPRRLCR
60 70 80 90 100
LRWDFVLPPV GAAVSLRRRD SGTPVVFSSS NDPEGMEFSS PSREECPKPL
110 120 130 140 150
SRVSIMAGSL TGLLLLQAVS WASGARPCIP KSFGYSSVVC VCNATYCDSF
160 170 180 190 200
DPPTFPALGT FSRYESTRSG RRMELSMGPI QANHTGTGLL LTLQPEQKFQ
210 220 230 240 250
KVKGFGGAMT DAAALNILAL SPPAQNLLLK SYFSEEGIGY NIIRVPMASC
260 270 280 290 300
DFSIRTYTYA DTPDDFQLHN FGLPEEDTKL KIPLIHRALQ LAQRPVSLLA
310 320 330 340 350
SPWTSPTWLK TNGAVNGKGS LKGQPGDIYH QTWARYFVKF LDAYAEHKLQ
360 370 380 390 400
FWAVTAENEP SAGLLSGYPF QCLGFTPEHQ RDFIARDLGP TLANSTHHNV
410 420 430 440 450
RLLMLDDQRL LLPHWAKVVL TDPEAAKYVH GIAVHWYLDF LAPAKATLGE
460 470 480 490 500
THRLFPNTML FASEACVGSK FWEQSVRLGS WDRGMQYSHS IITNLLYHVV
510 520 530 540 550
GWTDWNLALN PEGGPNWVRN FVDSPIIVDI TKDTFYKQPM FYHLGHFSKF
560 570 580 590 600
IPEGSQRVGL VASQKNDLDA VALMHPDGSA VVVVLNRSSK DVPLTIKDPA
610 620
VGFLETISPG YSIHTYLWRR Q
Length:621
Mass (Da):68,761
Last modified:March 3, 2009 - v1
Checksum:iE93D9A5ECE05AB07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300876 mRNA. Translation: BAH13365.1.
RefSeqiNP_001005741.1. NM_001005741.2.
NP_001005742.1. NM_001005742.2.
NP_001165282.1. NM_001171811.1.
UniGeneiHs.282997.

Genome annotation databases

GeneIDi2629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300876 mRNA. Translation: BAH13365.1.
RefSeqiNP_001005741.1. NM_001005741.2.
NP_001005742.1. NM_001005742.2.
NP_001165282.1. NM_001171811.1.
UniGeneiHs.282997.

3D structure databases

ProteinModelPortaliB7Z6S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7Z6S9. 1 interaction.
STRINGi9606.ENSP00000314508.

Protein family/group databases

Allergomei8244. Hom s Glucocerebrosidase.

Proteomic databases

PRIDEiB7Z6S9.

Protocols and materials databases

DNASUi2629.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2629.

Organism-specific databases

CTDi2629.
PharmGKBiPA28591.

Phylogenomic databases

HOGENOMiHOG000270031.
HOVERGENiHBG002285.

Miscellaneous databases

GenomeRNAii2629.
NextBioi10357.

Gene expression databases

GenevisibleiB7Z6S9. HS.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Small intestineImported.

Entry informationi

Entry nameiB7Z6S9_HUMAN
AccessioniPrimary (citable) accession number: B7Z6S9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 22, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.