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B7Z6S9

- B7Z6S9_HUMAN

UniProt

B7Z6S9 - B7Z6S9_HUMAN

Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

    GO - Molecular functioni

    1. glucosylceramidase activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. sphingolipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolismUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28591.

    Protein family/group databases

    Allergomei8244. Hom s Glucocerebrosidase.

    PTM / Processingi

    Proteomic databases

    PRIDEiB7Z6S9.

    Structurei

    3D structure databases

    ProteinModelPortaliB7Z6S9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 30 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000270031.
    HOVERGENiHBG002285.
    KOiK01201.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR11069. PTHR11069. 1 hit.
    PfamiPF02055. Glyco_hydro_30. 1 hit.
    [Graphical view]
    PRINTSiPR00843. GLHYDRLASE30.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7Z6S9-1 [UniParc]FASTAAdd to Basket

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    MSDRLFSNPG PAPTPQGCFS RGCGWSGCIL PSESYCAGPQ SPVPPRRLCR    50
    LRWDFVLPPV GAAVSLRRRD SGTPVVFSSS NDPEGMEFSS PSREECPKPL 100
    SRVSIMAGSL TGLLLLQAVS WASGARPCIP KSFGYSSVVC VCNATYCDSF 150
    DPPTFPALGT FSRYESTRSG RRMELSMGPI QANHTGTGLL LTLQPEQKFQ 200
    KVKGFGGAMT DAAALNILAL SPPAQNLLLK SYFSEEGIGY NIIRVPMASC 250
    DFSIRTYTYA DTPDDFQLHN FGLPEEDTKL KIPLIHRALQ LAQRPVSLLA 300
    SPWTSPTWLK TNGAVNGKGS LKGQPGDIYH QTWARYFVKF LDAYAEHKLQ 350
    FWAVTAENEP SAGLLSGYPF QCLGFTPEHQ RDFIARDLGP TLANSTHHNV 400
    RLLMLDDQRL LLPHWAKVVL TDPEAAKYVH GIAVHWYLDF LAPAKATLGE 450
    THRLFPNTML FASEACVGSK FWEQSVRLGS WDRGMQYSHS IITNLLYHVV 500
    GWTDWNLALN PEGGPNWVRN FVDSPIIVDI TKDTFYKQPM FYHLGHFSKF 550
    IPEGSQRVGL VASQKNDLDA VALMHPDGSA VVVVLNRSSK DVPLTIKDPA 600
    VGFLETISPG YSIHTYLWRR Q 621
    Length:621
    Mass (Da):68,761
    Last modified:March 3, 2009 - v1
    Checksum:iE93D9A5ECE05AB07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300876 mRNA. Translation: BAH13365.1.
    RefSeqiNP_001005741.1. NM_001005741.2.
    NP_001005742.1. NM_001005742.2.
    NP_001165282.1. NM_001171811.1.
    UniGeneiHs.282997.

    Genome annotation databases

    GeneIDi2629.
    KEGGihsa:2629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300876 mRNA. Translation: BAH13365.1 .
    RefSeqi NP_001005741.1. NM_001005741.2.
    NP_001005742.1. NM_001005742.2.
    NP_001165282.1. NM_001171811.1.
    UniGenei Hs.282997.

    3D structure databases

    ProteinModelPortali B7Z6S9.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 8244. Hom s Glucocerebrosidase.

    Proteomic databases

    PRIDEi B7Z6S9.

    Protocols and materials databases

    DNASUi 2629.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2629.
    KEGGi hsa:2629.

    Organism-specific databases

    CTDi 2629.
    PharmGKBi PA28591.

    Phylogenomic databases

    HOGENOMi HOG000270031.
    HOVERGENi HBG002285.
    KOi K01201.

    Miscellaneous databases

    GenomeRNAii 2629.
    NextBioi 10357.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR11069. PTHR11069. 1 hit.
    Pfami PF02055. Glyco_hydro_30. 1 hit.
    [Graphical view ]
    PRINTSi PR00843. GLHYDRLASE30.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Small intestineImported.

    Entry informationi

    Entry nameiB7Z6S9_HUMAN
    AccessioniPrimary (citable) accession number: B7Z6S9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.