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B7Z6S9

- B7Z6S9_HUMAN

UniProt

B7Z6S9 - B7Z6S9_HUMAN

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Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

  1. glucosylceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. sphingolipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28591.

Protein family/group databases

Allergomei8244. Hom s Glucocerebrosidase.

PTM / Processingi

Proteomic databases

PRIDEiB7Z6S9.

Interactioni

Protein-protein interaction databases

IntActiB7Z6S9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliB7Z6S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000270031.
HOVERGENiHBG002285.
KOiK01201.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z6S9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRLFSNPG PAPTPQGCFS RGCGWSGCIL PSESYCAGPQ SPVPPRRLCR
60 70 80 90 100
LRWDFVLPPV GAAVSLRRRD SGTPVVFSSS NDPEGMEFSS PSREECPKPL
110 120 130 140 150
SRVSIMAGSL TGLLLLQAVS WASGARPCIP KSFGYSSVVC VCNATYCDSF
160 170 180 190 200
DPPTFPALGT FSRYESTRSG RRMELSMGPI QANHTGTGLL LTLQPEQKFQ
210 220 230 240 250
KVKGFGGAMT DAAALNILAL SPPAQNLLLK SYFSEEGIGY NIIRVPMASC
260 270 280 290 300
DFSIRTYTYA DTPDDFQLHN FGLPEEDTKL KIPLIHRALQ LAQRPVSLLA
310 320 330 340 350
SPWTSPTWLK TNGAVNGKGS LKGQPGDIYH QTWARYFVKF LDAYAEHKLQ
360 370 380 390 400
FWAVTAENEP SAGLLSGYPF QCLGFTPEHQ RDFIARDLGP TLANSTHHNV
410 420 430 440 450
RLLMLDDQRL LLPHWAKVVL TDPEAAKYVH GIAVHWYLDF LAPAKATLGE
460 470 480 490 500
THRLFPNTML FASEACVGSK FWEQSVRLGS WDRGMQYSHS IITNLLYHVV
510 520 530 540 550
GWTDWNLALN PEGGPNWVRN FVDSPIIVDI TKDTFYKQPM FYHLGHFSKF
560 570 580 590 600
IPEGSQRVGL VASQKNDLDA VALMHPDGSA VVVVLNRSSK DVPLTIKDPA
610 620
VGFLETISPG YSIHTYLWRR Q
Length:621
Mass (Da):68,761
Last modified:March 3, 2009 - v1
Checksum:iE93D9A5ECE05AB07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300876 mRNA. Translation: BAH13365.1.
RefSeqiNP_001005741.1. NM_001005741.2.
NP_001005742.1. NM_001005742.2.
NP_001165282.1. NM_001171811.1.
UniGeneiHs.282997.

Genome annotation databases

GeneIDi2629.
KEGGihsa:2629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300876 mRNA. Translation: BAH13365.1 .
RefSeqi NP_001005741.1. NM_001005741.2.
NP_001005742.1. NM_001005742.2.
NP_001165282.1. NM_001171811.1.
UniGenei Hs.282997.

3D structure databases

ProteinModelPortali B7Z6S9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi B7Z6S9. 1 interaction.

Protein family/group databases

Allergomei 8244. Hom s Glucocerebrosidase.

Proteomic databases

PRIDEi B7Z6S9.

Protocols and materials databases

DNASUi 2629.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2629.
KEGGi hsa:2629.

Organism-specific databases

CTDi 2629.
PharmGKBi PA28591.

Phylogenomic databases

HOGENOMi HOG000270031.
HOVERGENi HBG002285.
KOi K01201.

Miscellaneous databases

GenomeRNAii 2629.
NextBioi 10357.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR11069. PTHR11069. 1 hit.
Pfami PF02055. Glyco_hydro_30. 1 hit.
[Graphical view ]
PRINTSi PR00843. GLHYDRLASE30.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Small intestineImported.

Entry informationi

Entry nameiB7Z6S9_HUMAN
AccessioniPrimary (citable) accession number: B7Z6S9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.