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Protein

Serine/threonine-protein phosphatase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

CalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Expressioni

Gene expression databases

BgeeiB7Z6R7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354871.

Structurei

3D structure databases

ProteinModelPortaliB7Z6R7.
SMRiB7Z6R7. Positions 42-386, 399-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG008238.
KOiK13807.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view]
PIRSFiPIRSF000912. PPEF. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 3 hits.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z6R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENYTHIHK EELELRNQSL ESEQDMRDRW DYVDSIDVPD SYNGPRLQFP
60 70 80 90 100
LTCTDIDLLL EAFKEQQILH AHYVLEVLFE TKKVLKQMPN FTHIQTSPSK
110 120 130 140 150
EVTICGDLHG KLDDLFLIFY KNGLPSERNP YVFNGDFVDR GKNSIEILMI
160 170 180 190 200
LCVSFLVYPN DLHLNRGNHE DFMMNLRYGF TKEILHKYKL HGKRILQILE
210 220 230 240 250
EFYAWLPIGT IVDNEILVIH GGISETTDLN LLHRVERNKM KSVLIPPTET
260 270 280 290 300
NRDHDTDSKH NKVGVTFNAH GRIKTNGSPT EHLTEHEWEQ IIDILWSDPR
310 320 330 340 350
GKNGCFPNTC RGGGCYFGPD VTSKILNKYQ LKMLIRSHEC KPEGYEICHD
360 370 380 390 400
GKVVTIFSAS NYYEEGSNRG AYIKLCSGTT PRFFQYQVTK ATCFQPLRQR
410 420 430 440 450
VDTMENSAIK ILRERVISRK SDLTRAFQLQ DHRKSGKLSV SQWAFCMENI
460 470 480 490 500
LGLNLPWRSL SSNLVNIDQN GNVEYMSSFQ NIRIEKPVQE AHSTLVETLY
510 520 530 540 550
RYRSDLEIIF NAIDTDHSGL ISVEEFRAMW KLFSSHYNVH IDDSQVNKLA
560 570 580
NIMDLNKDGS IDFNEFLKAF YVVHRYEDLM KPDVTNLG
Length:588
Mass (Da):68,264
Last modified:March 3, 2009 - v1
Checksum:iC0335E9FEC8169F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300815 mRNA. Translation: BAH13353.1.
UniGeneiHs.211589.

Genome annotation databases

KEGGihsa:5475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300815 mRNA. Translation: BAH13353.1.
UniGeneiHs.211589.

3D structure databases

ProteinModelPortaliB7Z6R7.
SMRiB7Z6R7. Positions 42-386, 399-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGihsa:5475.

Organism-specific databases

CTDi5475.

Phylogenomic databases

HOVERGENiHBG008238.
KOiK13807.

Miscellaneous databases

ChiTaRSiPPEF1. human.
GenomeRNAii5475.
NextBioi35480043.

Gene expression databases

BgeeiB7Z6R7.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view]
PIRSFiPIRSF000912. PPEF. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 3 hits.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB7Z6R7_HUMAN
AccessioniPrimary (citable) accession number: B7Z6R7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 24, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.