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Protein

Serine/threonine-protein phosphatase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi514 – 525PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi554 – 565PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z6R7

Structurei

3D structure databases

ProteinModelPortaliB7Z6R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini418 – 453EF-handInterPro annotationAdd BLAST36
Domaini501 – 536EF-handInterPro annotationAdd BLAST36
Domaini541 – 576EF-handInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0377 Eukaryota
COG0639 LUCA
HOVERGENiHBG008238

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013235 PPP_dom
IPR012008 Ser/Thr-Pase_EF-hand_contain
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00149 Metallophos, 1 hit
PF08321 PPP5, 1 hit
PIRSFiPIRSF000912 PPEF, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SM00156 PP2Ac, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z6R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENYTHIHK EELELRNQSL ESEQDMRDRW DYVDSIDVPD SYNGPRLQFP
60 70 80 90 100
LTCTDIDLLL EAFKEQQILH AHYVLEVLFE TKKVLKQMPN FTHIQTSPSK
110 120 130 140 150
EVTICGDLHG KLDDLFLIFY KNGLPSERNP YVFNGDFVDR GKNSIEILMI
160 170 180 190 200
LCVSFLVYPN DLHLNRGNHE DFMMNLRYGF TKEILHKYKL HGKRILQILE
210 220 230 240 250
EFYAWLPIGT IVDNEILVIH GGISETTDLN LLHRVERNKM KSVLIPPTET
260 270 280 290 300
NRDHDTDSKH NKVGVTFNAH GRIKTNGSPT EHLTEHEWEQ IIDILWSDPR
310 320 330 340 350
GKNGCFPNTC RGGGCYFGPD VTSKILNKYQ LKMLIRSHEC KPEGYEICHD
360 370 380 390 400
GKVVTIFSAS NYYEEGSNRG AYIKLCSGTT PRFFQYQVTK ATCFQPLRQR
410 420 430 440 450
VDTMENSAIK ILRERVISRK SDLTRAFQLQ DHRKSGKLSV SQWAFCMENI
460 470 480 490 500
LGLNLPWRSL SSNLVNIDQN GNVEYMSSFQ NIRIEKPVQE AHSTLVETLY
510 520 530 540 550
RYRSDLEIIF NAIDTDHSGL ISVEEFRAMW KLFSSHYNVH IDDSQVNKLA
560 570 580
NIMDLNKDGS IDFNEFLKAF YVVHRYEDLM KPDVTNLG
Length:588
Mass (Da):68,264
Last modified:March 3, 2009 - v1
Checksum:iC0335E9FEC8169F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300815 mRNA Translation: BAH13353.1
UniGeneiHs.211589

Similar proteinsi

Entry informationi

Entry nameiB7Z6R7_HUMAN
AccessioniPrimary (citable) accession number: B7Z6R7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health