B7Z6R7 (B7Z6R7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase RuleBase RU004273
EC=3.1.3.16 RuleBase RU004273

Gene names

Name:

PPEF1 Ensembl ENSP00000441289

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAH13353.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. RuleBase RU004273
Sequence similarities	Belongs to the PPP phosphatase family. RuleBase RU004273

Ontologies

Keywords
Ligand	Calcium RuleBase RU000331 Iron RuleBase RU004273
Molecular function	Hydrolase RuleBase RU004273
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of stimulus involved in sensory perception Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: InterPro phosphoprotein phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z6R7 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: C0335E9FEC8169F0	FASTA	588	68,264
	10 20 30 40 50 60 MLENYTHIHK EELELRNQSL ESEQDMRDRW DYVDSIDVPD SYNGPRLQFP LTCTDIDLLL 70 80 90 100 110 120 EAFKEQQILH AHYVLEVLFE TKKVLKQMPN FTHIQTSPSK EVTICGDLHG KLDDLFLIFY 130 140 150 160 170 180 KNGLPSERNP YVFNGDFVDR GKNSIEILMI LCVSFLVYPN DLHLNRGNHE DFMMNLRYGF 190 200 210 220 230 240 TKEILHKYKL HGKRILQILE EFYAWLPIGT IVDNEILVIH GGISETTDLN LLHRVERNKM 250 260 270 280 290 300 KSVLIPPTET NRDHDTDSKH NKVGVTFNAH GRIKTNGSPT EHLTEHEWEQ IIDILWSDPR 310 320 330 340 350 360 GKNGCFPNTC RGGGCYFGPD VTSKILNKYQ LKMLIRSHEC KPEGYEICHD GKVVTIFSAS 370 380 390 400 410 420 NYYEEGSNRG AYIKLCSGTT PRFFQYQVTK ATCFQPLRQR VDTMENSAIK ILRERVISRK 430 440 450 460 470 480 SDLTRAFQLQ DHRKSGKLSV SQWAFCMENI LGLNLPWRSL SSNLVNIDQN GNVEYMSSFQ 490 500 510 520 530 540 NIRIEKPVQE AHSTLVETLY RYRSDLEIIF NAIDTDHSGL ISVEEFRAMW KLFSSHYNVH 550 560 570 580 IDDSQVNKLA NIMDLNKDGS IDFNEFLKAF YVVHRYEDLM KPDVTNLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL096700 Genomic DNA. No translation available. Z94056 Genomic DNA. No translation available. AK300815 mRNA. Translation: BAH13353.1.
IPI	IPI01012285.
UniGene	Hs.211589.
3D structure databases
SMR	B7Z6R7. Positions 42-386, 452-571.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000544635; ENSP00000441289; ENSG00000086717.
Organism-specific databases
HGNC	HGNC:9243. PPEF1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG008238.
Gene expression databases
ArrayExpress	B7Z6R7.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR004843. Metallo_PEstase_dom. IPR013235. PPP_dom. IPR012008. Ser/Thr-Pase_EF-hand_contain. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF13499. EF_hand_5. 1 hit. PF00149. Metallophos. 1 hit. PF08321. PPP5. 1 hit. [Graphical view]
PIRSF	PIRSF000912. PPEF. 1 hit.
PRINTS	PR00114. STPHPHTASE.
SMART	SM00054. EFh. 3 hits. SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 3 hits. PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35480043.

Entry information

Entry name

B7Z6R7_HUMAN

Accession

Primary (citable) accession number: B7Z6R7

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.