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Protein

Putative uncharacterized zinc finger protein 814

Gene

ZNF814

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri120 – 14223C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri688 – 71023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri716 – 73823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri744 – 76623C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri772 – 79423C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri800 – 82223C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri828 – 85023C2H2-type 23PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uncharacterized zinc finger protein 814
Alternative name(s):
Putative zinc finger protein LOC730051
Gene namesi
Name:ZNF814
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33258. ZNF814.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727759.

Polymorphism and mutation databases

BioMutaiZNF814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 855855Putative uncharacterized zinc finger protein 814PRO_0000394964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki335 – 335Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki391 – 391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiB7Z6K7.
PRIDEiB7Z6K7.
TopDownProteomicsiB7Z6K7.

PTM databases

iPTMnetiB7Z6K7.
PhosphoSiteiB7Z6K7.

Expressioni

Gene expression databases

BgeeiENSG00000204514.
ExpressionAtlasiB7Z6K7. baseline and differential.

Organism-specific databases

HPAiHPA053762.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410545.

Structurei

3D structure databases

ProteinModelPortaliB7Z6K7.
SMRiB7Z6K7. Positions 106-850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9177KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 23 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri120 – 14223C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri688 – 71023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri716 – 73823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri744 – 76623C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri772 – 79423C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri800 – 82223C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri828 – 85023C2H2-type 23PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB7Z6K7.
KOiK09228.
OMAiRVHPRER.
OrthoDBiEOG091G02KC.
PhylomeDBiB7Z6K7.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 23 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z6K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAATLRLS AQGTVTFEDV AVNFTWEEWN LLSEAQRCLY RDVTLENLAL
60 70 80 90 100
ISSLGCWCGV EDEAAPSKQS IYIQRETQVR TPMAGVSPKK AHPCEMCGPI
110 120 130 140 150
LGDILHVADH QGTHHKQKLH RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG
160 170 180 190 200
SVEEALFAKR CKLHVSGESS VFSESGKDFL PRSGLLQQEA SHTGEKSNSK
210 220 230 240 250
TECVSPIQCG GAHYSCGESM KHFSTKHILS QHQRLLTREE CYVCCECGKS
260 270 280 290 300
FSKYASLSNH QRVHTEKKHE CGECGKSFSK YVSFSNHQRV HTEKKHECGE
310 320 330 340 350
CGKSFSKYVS FSNHQRVHTG KRPYECGECG KSFSKYASFS NHQRVHTEKK
360 370 380 390 400
HYECGECGKS FSKYVSFSNH QRVHTGKRPY ECGECGKSFS KYASFSNHQR
410 420 430 440 450
VHTDKKHYEC GECGKSFSQK SSLIQHQRFH TGEKPYGCEE CGKSFSSEGH
460 470 480 490 500
LRSHQRVHAG ERPFKCGECV KSFSHKRSLV HHQRVHSGER PYQCGECGKS
510 520 530 540 550
FSQKGNLVLH QRVHTGARPY ECGECGKSFS SKGHLRNHQQ IHTGDRLYEC
560 570 580 590 600
GECGKSFSHK GTLILHQRVH PRERSYGCGE CGKSFSSIGH LRSHQRVHTG
610 620 630 640 650
ERPYECGECG KSFSHKRSLV HHQRMHTGER PYKCGDCGKS FNEKGHLRNH
660 670 680 690 700
QRVHTTERPF KCGECGKCFS HKGNLILHQH GHTGERPYVC RECGKLFKKK
710 720 730 740 750
SHLLVHQRIH NGEKPYACEA CQKFFRNKYQ LIAHQRVHTG ERPYECNDCG
760 770 780 790 800
KSFTHSSTFC VHKRIHTGEK PYECSECGKS FAESSSFTKH KRVHTGEKPY
810 820 830 840 850
ECSECGKSFA ESSSLTKHKR VHTGEKPYKC EKCGKLFNKK SHLLVHQSSH

WRKAI
Length:855
Mass (Da):97,337
Last modified:June 15, 2010 - v2
Checksum:i7C497F30FCAACB17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581A → V in BAH13293 (PubMed:14702039).Curated
Sequence conflicti230 – 2301S → C in BAH13293 (PubMed:14702039).Curated
Sequence conflicti296 – 2961H → HY in BAH13293 (PubMed:14702039).Curated
Sequence conflicti296 – 2961H → HY in EAW72539 (Ref. 3) Curated
Sequence conflicti591 – 5911L → H in BAH13293 (PubMed:14702039).Curated
Sequence conflicti769 – 7691E → K in BAH13293 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831M → V.
Corresponds to variant rs52826274 [ dbSNP | Ensembl ].
VAR_063261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300483 mRNA. Translation: BAH13293.1.
AC010326 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72539.1.
CCDSiCCDS46212.1.
RefSeqiNP_001138461.1. NM_001144989.1.
UniGeneiHs.634143.
Hs.733810.

Genome annotation databases

EnsembliENST00000435989; ENSP00000410545; ENSG00000204514.
GeneIDi730051.
KEGGihsa:730051.
UCSCiuc002qqo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300483 mRNA. Translation: BAH13293.1.
AC010326 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72539.1.
CCDSiCCDS46212.1.
RefSeqiNP_001138461.1. NM_001144989.1.
UniGeneiHs.634143.
Hs.733810.

3D structure databases

ProteinModelPortaliB7Z6K7.
SMRiB7Z6K7. Positions 106-850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000410545.

PTM databases

iPTMnetiB7Z6K7.
PhosphoSiteiB7Z6K7.

Polymorphism and mutation databases

BioMutaiZNF814.

Proteomic databases

PaxDbiB7Z6K7.
PRIDEiB7Z6K7.
TopDownProteomicsiB7Z6K7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435989; ENSP00000410545; ENSG00000204514.
GeneIDi730051.
KEGGihsa:730051.
UCSCiuc002qqo.3. human.

Organism-specific databases

CTDi730051.
GeneCardsiZNF814.
HGNCiHGNC:33258. ZNF814.
HPAiHPA053762.
neXtProtiNX_B7Z6K7.
PharmGKBiPA164727759.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB7Z6K7.
KOiK09228.
OMAiRVHPRER.
OrthoDBiEOG091G02KC.
PhylomeDBiB7Z6K7.
TreeFamiTF343410.

Miscellaneous databases

ChiTaRSiZNF814. human.
GenomeRNAii730051.
PROiB7Z6K7.

Gene expression databases

BgeeiENSG00000204514.
ExpressionAtlasiB7Z6K7. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 23 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN814_HUMAN
AccessioniPrimary (citable) accession number: B7Z6K7
Secondary accession number(s): A6NF35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 7, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.