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Protein
Submitted name:

cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiB7Z6G2
PeptideAtlasiB7Z6G2
PRIDEiB7Z6G2

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiB7Z6G2, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliB7Z6G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 140SH3InterPro annotationAdd BLAST60
Domaini168 – 348DHInterPro annotationAdd BLAST181
Domaini370 – 475PHInterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili314 – 334Sequence analysisAdd BLAST21
Coiled coili349 – 369Sequence analysisAdd BLAST21
Coiled coili669 – 710Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
HOVERGENiHBG050569

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035789 BetaPIX_SH3
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR032409 GEF_CC
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF16523 betaPIX_CC, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z6G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFDANDLY QGQNFNKVLS SLVTLNKVTA DIGLGSDSVC ARPSSHRIKS
60 70 80 90 100
FDSLGSQSLH TRTSKLFQGQ YRSLDMTDNS NNQLVVRAKF NFQQTNEDEL
110 120 130 140 150
SFSKGDVIHV TRVEEGGWWE GTLNGRTGWF PSNYVREVKA SEKPVSPKSG
160 170 180 190 200
TLKSPPKGFD TTAINKSYYN VVLQNILETE NEYSKELQTV LSTYLRPLQT
210 220 230 240 250
SEKLSSANIS YLMGNLEEIC SFQQMLVQSL EECTKLPEAQ QRVGGCFLNL
260 270 280 290 300
MPQMKTLYLT YCANHPSAVN VLTEHSEELG EFMETKGASS PGILVLTTGL
310 320 330 340 350
SKPFMRLDKY PTLLKELERH MEDYHTDRQD IQKSMAAFKN LSAQCQEVRK
360 370 380 390 400
RKELELQILT EAIRNWEGDD IKTLGNVTYM SQVLIQCAGS EEKNERYLLL
410 420 430 440 450
FPNVLLMLSA SPRMSGFIYQ GKLPTTGMTI TKLEDSENHR NAFEISGSMI
460 470 480 490 500
ERILVSCNNQ QDLQEWVEHL QKQTKVTSVG NPTIKPHSVP SHTLPSHPVT
510 520 530 540 550
PSSKHADSKP APLTPAYHTL PHPSHHGTPH TTINWGPLEP PKTPKPWSLS
560 570 580 590 600
CLRPAPPLRP SAALCYKEDL SKSPKTMKKL LPKRKPERKP SDEEFASRKS
610 620 630 640 650
TAALEEDAQI LKVIEAYCTS AKTRQTLNSS SRKESAPQVL LPEEEKIIVE
660 670 680 690 700
ETKSNGQTVI EEKSLVDTVY ALKDEVQELR QDNKKMKKSL EEEQRARKDL
710 720
EKLVRKVLKN MNDPAWDETN L
Length:721
Mass (Da):81,404
Last modified:March 3, 2009 - v1
Checksum:i4051F1413D21F0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300272 mRNA Translation: BAH13248.1
RefSeqiNP_001307782.1, NM_001320853.1
UniGeneiHs.508738

Genome annotation databases

GeneIDi8874

Similar proteinsi

Entry informationi

Entry nameiB7Z6G2_HUMAN
AccessioniPrimary (citable) accession number: B7Z6G2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Main funding by: National Institutes of Health