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B7Z6G2

- B7Z6G2_HUMAN

UniProt

B7Z6G2 - B7Z6G2_HUMAN

Protein
Submitted name:

cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factorSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Family & Domainsi

    Sequence similaritiesi

    Contains DH (DBL-homology) domain.SAAS annotation
    Contains PH domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG050569.
    KOiK13710.
    OMAiPQMKSLY.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7Z6G2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTFDANDLY QGQNFNKVLS SLVTLNKVTA DIGLGSDSVC ARPSSHRIKS    50
    FDSLGSQSLH TRTSKLFQGQ YRSLDMTDNS NNQLVVRAKF NFQQTNEDEL 100
    SFSKGDVIHV TRVEEGGWWE GTLNGRTGWF PSNYVREVKA SEKPVSPKSG 150
    TLKSPPKGFD TTAINKSYYN VVLQNILETE NEYSKELQTV LSTYLRPLQT 200
    SEKLSSANIS YLMGNLEEIC SFQQMLVQSL EECTKLPEAQ QRVGGCFLNL 250
    MPQMKTLYLT YCANHPSAVN VLTEHSEELG EFMETKGASS PGILVLTTGL 300
    SKPFMRLDKY PTLLKELERH MEDYHTDRQD IQKSMAAFKN LSAQCQEVRK 350
    RKELELQILT EAIRNWEGDD IKTLGNVTYM SQVLIQCAGS EEKNERYLLL 400
    FPNVLLMLSA SPRMSGFIYQ GKLPTTGMTI TKLEDSENHR NAFEISGSMI 450
    ERILVSCNNQ QDLQEWVEHL QKQTKVTSVG NPTIKPHSVP SHTLPSHPVT 500
    PSSKHADSKP APLTPAYHTL PHPSHHGTPH TTINWGPLEP PKTPKPWSLS 550
    CLRPAPPLRP SAALCYKEDL SKSPKTMKKL LPKRKPERKP SDEEFASRKS 600
    TAALEEDAQI LKVIEAYCTS AKTRQTLNSS SRKESAPQVL LPEEEKIIVE 650
    ETKSNGQTVI EEKSLVDTVY ALKDEVQELR QDNKKMKKSL EEEQRARKDL 700
    EKLVRKVLKN MNDPAWDETN L 721
    Length:721
    Mass (Da):81,404
    Last modified:March 3, 2009 - v1
    Checksum:i4051F1413D21F0E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300272 mRNA. Translation: BAH13248.1.
    RefSeqiXP_005254148.1. XM_005254091.1.
    UniGeneiHs.508738.

    Genome annotation databases

    GeneIDi8874.
    KEGGihsa:8874.
    UCSCiuc010tjo.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300272 mRNA. Translation: BAH13248.1 .
    RefSeqi XP_005254148.1. XM_005254091.1.
    UniGenei Hs.508738.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8874.
    KEGGi hsa:8874.
    UCSCi uc010tjo.2. human.

    Organism-specific databases

    CTDi 8874.

    Phylogenomic databases

    HOVERGENi HBG050569.
    KOi K13710.
    OMAi PQMKSLY.

    Miscellaneous databases

    ChiTaRSi ARHGEF7. human.
    GenomeRNAii 8874.
    NextBioi 35479963.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PlacentaImported.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiB7Z6G2_HUMAN
    AccessioniPrimary (citable) accession number: B7Z6G2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.