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B7Z6E6

- B7Z6E6_HUMAN

UniProt

B7Z6E6 - B7Z6E6_HUMAN

Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

    GO - Molecular functioni

    1. glucosylceramidase activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. sphingolipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolismUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: UniProtKB

    Pathology & Biotechi

    Protein family/group databases

    Allergomei8244. Hom s Glucocerebrosidase.

    PTM / Processingi

    Proteomic databases

    PRIDEiB7Z6E6.

    Structurei

    3D structure databases

    ProteinModelPortaliB7Z6E6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 30 family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG002285.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR11069. PTHR11069. 1 hit.
    PfamiPF02055. Glyco_hydro_30. 1 hit.
    [Graphical view]
    PRINTSiPR00843. GLHYDRLASE30.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7Z6E6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSSPSREE CPKPLSRVSV MAGSLTGLLL LQAVSWASGA RPCIPKSFGY    50
    SSVVCVCNAT YCDSFDPPTF PALGTFSRYE STRSGRRMEL SMGPIQANHT 100
    GTGLLLTLQP DAAALNILAL SPPAQNLLLK SYFSEEGIGY NIIRVPMASC 150
    DFSIRTYTYA DTPDDFQLHN FSLPEEDTKL KIPLIHRALQ LAQRPVSLLA 200
    SPWTSPTWLK TNGAVNGKGS LKGQPGDIYH QTWARYFVKF LDAYAEHKLQ 250
    FWAVTAENEP SAGLLSGYPF QCLGFTPEHQ RDFIARDLGP TLANSTHHNV 300
    RLLMLDDQRL LLPHWAKVVL TDPEAAKYVH GIAVHWYLDF LAPAKATLGE 350
    THRLFPNTML FASEACVGSK FWEQSVRLGS WDRGMQYSHS IITNLLYHVV 400
    GWTDWNLALN PEGGPNWVRN FVDSPIIVDI TKDTFYKQPM FYHLGHFSKF 450
    IPEGSQRVGL VASQKNDLDA VALMHPDGSA VVVVLNRPSK DVPLTIKDPA 500
    VGFLETISPG YSIHTYLWRR Q 521
    Length:521
    Mass (Da):58,074
    Last modified:March 3, 2009 - v1
    Checksum:iAFE7FBC81EB406C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300186 mRNA. Translation: BAH13232.1.
    UniGeneiHs.282997.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300186 mRNA. Translation: BAH13232.1 .
    UniGenei Hs.282997.

    3D structure databases

    ProteinModelPortali B7Z6E6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 8244. Hom s Glucocerebrosidase.

    Proteomic databases

    PRIDEi B7Z6E6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG002285.

    Miscellaneous databases

    NextBioi 35479950.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR11069. PTHR11069. 1 hit.
    Pfami PF02055. Glyco_hydro_30. 1 hit.
    [Graphical view ]
    PRINTSi PR00843. GLHYDRLASE30.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PlacentaImported.

    Entry informationi

    Entry nameiB7Z6E6_HUMAN
    AccessioniPrimary (citable) accession number: B7Z6E6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.