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Protein
Submitted name:

Active breakpoint cluster region-related protein

Gene

ABR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Active breakpoint cluster region-related proteinImported
Submitted name:
cDNA FLJ54747, highly similar to Active breakpoint cluster region-related proteinImported
Gene namesi
Name:ABRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:81. ABR.

PTM / Processingi

Proteomic databases

EPDiB7Z683.

Expressioni

Gene expression databases

ExpressionAtlasiB7Z683. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303909.

Structurei

3D structure databases

SMRiB7Z683. Positions 15-117, 284-356, 442-623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 6650DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini83 – 241159PHInterPro annotationAdd
BLAST
Domaini288 – 37790C2InterPro annotationAdd
BLAST
Domaini429 – 627199Rho-GAPInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation
Contains Rho-GAP domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
GeneTreeiENSGT00840000129703.
HOVERGENiHBG004165.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEILLIIRFC CNCTYALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ
60 70 80 90 100
DALRISQNFL SSINEDIDPR RTAVTTPKGE TRQLVKDGFL VEVSESSRKL
110 120 130 140 150
RHVFLFTDVL LCAKLKKTSA GKHQQYDCKW YIPLADLVFP SPEESEASPQ
160 170 180 190 200
VHPFPDHELE DMKMKISALK SEIQKEKANK GQSRAIERLK KKMFENEFLL
210 220 230 240 250
LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ KKDLQAFVLS
260 270 280 290 300
SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ
310 320 330 340 350
SANLYCTLEV DSFGYFVSKA KTRVFRDTAE PKWDEEFEIE LEGSQSLRIL
360 370 380 390 400
CYEKCYDKTK VNKDNNEIVD KIMGKGQIQL DPQTVETKNW HTDVIEMNGI
410 420 430 440 450
KVEFSMKFTS RDMSLKRTPS KKQTGVFGVK ISVVTKRERS KVPYIVRQCV
460 470 480 490 500
EEVEKRGIEE VGIYRISGVA TDIQALKAVF DANNKDILLM LSDMDINAIA
510 520 530 540 550
GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM HLLRSLPDPN
560 570 580 590 600
LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS
610 620 630 640
AADIWSHDVM AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V
Length:641
Mass (Da):73,517
Last modified:March 3, 2009 - v1
Checksum:iFE84A80387020D68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015884 Genomic DNA. No translation available.
AC016292 Genomic DNA. No translation available.
AC107911 Genomic DNA. No translation available.
AC144836 Genomic DNA. No translation available.
AC212841 Genomic DNA. No translation available.
AC226497 Genomic DNA. No translation available.
KF456222 Genomic DNA. No translation available.
AK299909 mRNA. Translation: BAH13169.1.
RefSeqiNP_001243776.1. NM_001256847.2.
NP_001269078.1. NM_001282149.1.
UniGeneiHs.159306.

Genome annotation databases

EnsembliENST00000536794; ENSP00000437429; ENSG00000159842.
ENST00000619569; ENSP00000480343; ENSG00000278741.
ENST00000631260; ENSP00000487391; ENSG00000276016.
GeneIDi29.
UCSCiuc010vqg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015884 Genomic DNA. No translation available.
AC016292 Genomic DNA. No translation available.
AC107911 Genomic DNA. No translation available.
AC144836 Genomic DNA. No translation available.
AC212841 Genomic DNA. No translation available.
AC226497 Genomic DNA. No translation available.
KF456222 Genomic DNA. No translation available.
AK299909 mRNA. Translation: BAH13169.1.
RefSeqiNP_001243776.1. NM_001256847.2.
NP_001269078.1. NM_001282149.1.
UniGeneiHs.159306.

3D structure databases

SMRiB7Z683. Positions 15-117, 284-356, 442-623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303909.

Proteomic databases

EPDiB7Z683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000536794; ENSP00000437429; ENSG00000159842.
ENST00000619569; ENSP00000480343; ENSG00000278741.
ENST00000631260; ENSP00000487391; ENSG00000276016.
GeneIDi29.
UCSCiuc010vqg.4. human.

Organism-specific databases

CTDi29.
HGNCiHGNC:81. ABR.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
GeneTreeiENSGT00840000129703.
HOVERGENiHBG004165.

Miscellaneous databases

ChiTaRSiABR. human.
GenomeRNAii29.
NextBioi101.

Gene expression databases

ExpressionAtlasiB7Z683. baseline and differential.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  4. Ensembl
    Submitted (JUN-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7Z683_HUMAN
AccessioniPrimary (citable) accession number: B7Z683
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.