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Protein
Submitted name:

cDNA FLJ54747, highly similar to Active breakpoint cluster region-related protein

Gene

ABR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ54747, highly similar to Active breakpoint cluster region-related proteinImported
Gene namesi
Name:ABRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000159842.14
HGNCiHGNC:81 ABR

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159842

PTM / Processingi

Proteomic databases

MaxQBiB7Z683
PeptideAtlasiB7Z683
PRIDEiB7Z683

Expressioni

Gene expression databases

BgeeiENSG00000159842
ExpressionAtlasiB7Z683 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 66DHInterPro annotationAdd BLAST50
Domaini83 – 241PHInterPro annotationAdd BLAST159
Domaini288 – 377C2InterPro annotationAdd BLAST90
Domaini429 – 627Rho-GAPInterPro annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili159 – 179Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4269 Eukaryota
ENOG410XPGZ LUCA
GeneTreeiENSGT00920000148945
HOVERGENiHBG004165

Family and domain databases

CDDicd13366 PH_ABR, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.900.10, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037769 Abr/Bcr
IPR037865 ABR_PH
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PANTHERiPTHR23182 PTHR23182, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEILLIIRFC CNCTYALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ
60 70 80 90 100
DALRISQNFL SSINEDIDPR RTAVTTPKGE TRQLVKDGFL VEVSESSRKL
110 120 130 140 150
RHVFLFTDVL LCAKLKKTSA GKHQQYDCKW YIPLADLVFP SPEESEASPQ
160 170 180 190 200
VHPFPDHELE DMKMKISALK SEIQKEKANK GQSRAIERLK KKMFENEFLL
210 220 230 240 250
LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ KKDLQAFVLS
260 270 280 290 300
SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ
310 320 330 340 350
SANLYCTLEV DSFGYFVSKA KTRVFRDTAE PKWDEEFEIE LEGSQSLRIL
360 370 380 390 400
CYEKCYDKTK VNKDNNEIVD KIMGKGQIQL DPQTVETKNW HTDVIEMNGI
410 420 430 440 450
KVEFSMKFTS RDMSLKRTPS KKQTGVFGVK ISVVTKRERS KVPYIVRQCV
460 470 480 490 500
EEVEKRGIEE VGIYRISGVA TDIQALKAVF DANNKDILLM LSDMDINAIA
510 520 530 540 550
GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM HLLRSLPDPN
560 570 580 590 600
LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS
610 620 630 640
AADIWSHDVM AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V
Length:641
Mass (Da):73,517
Last modified:March 3, 2009 - v1
Checksum:iFE84A80387020D68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015884 Genomic DNA No translation available.
AC016292 Genomic DNA No translation available.
AC107911 Genomic DNA No translation available.
AC144836 Genomic DNA No translation available.
AC212841 Genomic DNA No translation available.
AC226497 Genomic DNA No translation available.
KF456222 Genomic DNA No translation available.
AK299909 mRNA Translation: BAH13169.1
RefSeqiNP_001243776.1, NM_001256847.2
NP_001269078.1, NM_001282149.1
UniGeneiHs.159306
Hs.677395

Genome annotation databases

EnsembliENST00000536794; ENSP00000437429; ENSG00000159842
ENST00000619569; ENSP00000480343; ENSG00000278741
ENST00000631260; ENSP00000487391; ENSG00000276016
GeneIDi29
UCSCiuc010vqg.4 human

Similar proteinsi

Entry informationi

Entry nameiB7Z683_HUMAN
AccessioniPrimary (citable) accession number: B7Z683
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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