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Protein
Submitted name:

Active breakpoint cluster region-related protein

Gene

ABR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Active breakpoint cluster region-related proteinImported
Submitted name:
cDNA FLJ54747, highly similar to Active breakpoint cluster region-related proteinImported
Gene namesi
Name:ABRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000159842.14.
HGNCiHGNC:81. ABR.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159842.

PTM / Processingi

Proteomic databases

MaxQBiB7Z683.

Expressioni

Gene expression databases

BgeeiENSG00000159842.
ExpressionAtlasiB7Z683. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 66DHInterPro annotationAdd BLAST50
Domaini83 – 241PHInterPro annotationAdd BLAST159
Domaini288 – 377C2InterPro annotationAdd BLAST90
Domaini429 – 627Rho-GAPInterPro annotationAdd BLAST199

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
GeneTreeiENSGT00890000139322.
HOVERGENiHBG004165.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEILLIIRFC CNCTYALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ
60 70 80 90 100
DALRISQNFL SSINEDIDPR RTAVTTPKGE TRQLVKDGFL VEVSESSRKL
110 120 130 140 150
RHVFLFTDVL LCAKLKKTSA GKHQQYDCKW YIPLADLVFP SPEESEASPQ
160 170 180 190 200
VHPFPDHELE DMKMKISALK SEIQKEKANK GQSRAIERLK KKMFENEFLL
210 220 230 240 250
LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ KKDLQAFVLS
260 270 280 290 300
SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ
310 320 330 340 350
SANLYCTLEV DSFGYFVSKA KTRVFRDTAE PKWDEEFEIE LEGSQSLRIL
360 370 380 390 400
CYEKCYDKTK VNKDNNEIVD KIMGKGQIQL DPQTVETKNW HTDVIEMNGI
410 420 430 440 450
KVEFSMKFTS RDMSLKRTPS KKQTGVFGVK ISVVTKRERS KVPYIVRQCV
460 470 480 490 500
EEVEKRGIEE VGIYRISGVA TDIQALKAVF DANNKDILLM LSDMDINAIA
510 520 530 540 550
GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM HLLRSLPDPN
560 570 580 590 600
LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS
610 620 630 640
AADIWSHDVM AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V
Length:641
Mass (Da):73,517
Last modified:March 3, 2009 - v1
Checksum:iFE84A80387020D68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015884 Genomic DNA. No translation available.
AC016292 Genomic DNA. No translation available.
AC107911 Genomic DNA. No translation available.
AC144836 Genomic DNA. No translation available.
AC212841 Genomic DNA. No translation available.
AC226497 Genomic DNA. No translation available.
KF456222 Genomic DNA. No translation available.
AK299909 mRNA. Translation: BAH13169.1.
RefSeqiNP_001243776.1. NM_001256847.2.
NP_001269078.1. NM_001282149.1.
UniGeneiHs.159306.
Hs.677395.

Genome annotation databases

EnsembliENST00000536794; ENSP00000437429; ENSG00000159842.
ENST00000619569; ENSP00000480343; ENSG00000278741.
ENST00000631260; ENSP00000487391; ENSG00000276016.
GeneIDi29.
UCSCiuc010vqg.4. human.

Similar proteinsi

Entry informationi

Entry nameiB7Z683_HUMAN
AccessioniPrimary (citable) accession number: B7Z683
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported