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Protein
Submitted name:

Mitochondrial sodium/hydrogen exchanger 9B2

Gene

SLC9B2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial sodium/hydrogen exchanger 9B2Imported
Submitted name:
cDNA FLJ50743Imported
Gene namesi
Name:SLC9B2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25143. SLC9B2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei176 – 19924HelicalSequence analysisAdd
BLAST
Transmembranei249 – 26719HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29820HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiB7Z676. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 357267Na_H_ExchangerInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000013285.
HOGENOMiHOG000060325.
HOVERGENiHBG108184.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR030187. NHA2.
[Graphical view]
PANTHERiPTHR31102:SF6. PTHR31102:SF6. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEDKRITY EDSEPSTGMN YTPSMHQEAQ EETVMKLKGI DANEPTEGSI
60 70 80 90 100
LLKSSEKKLQ ETPTEANHVQ RLRQMLACPP HGLLDRVITN GMLLAGFLIR
110 120 130 140 150
NIPVINDNVQ IKHKWSSSLR SIALSIILVR AGLGLDSKAL KKLKGVCVRL
160 170 180 190 200
SMGPCIVEAC TSALLAHYLL GLPWQWGFIL GFVLGAVSPA VVVPSMLLLQ
210 220 230 240 250
GGGYGVEKGV PTLLMAAGSF DDILAITGFN TCLGIAFSTG STVFNVLRGV
260 270 280 290 300
LEVVIGVATG SVLGFFIQYF PSRDQDKLVC KRTFLVLGLS VLAVFSSVHF
310 320 330 340 350
GFPGSGGLCT LVMAFLAGMG WTSEKAEVEK IIAVAWDIFQ PLLFGLIGAE
360 370 380 390 400
VSIASLRPET VGCNRICGFG HSKVTWRETI RRLWNGCVDS GIFVHPHHSP
410
NWKSAYWFTG PQASAES
Length:417
Mass (Da):45,112
Last modified:March 3, 2009 - v1
Checksum:i112781D056B8A3DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097485 Genomic DNA. No translation available.
AK299888 mRNA. Translation: BAH13162.1.
RefSeqiNP_001287683.1. NM_001300754.1.
NP_001287685.1. NM_001300756.1.
UniGeneiHs.546482.

Genome annotation databases

EnsembliENST00000503103; ENSP00000425385; ENSG00000164038.
GeneIDi133308.
KEGGihsa:133308.
UCSCiuc011cex.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097485 Genomic DNA. No translation available.
AK299888 mRNA. Translation: BAH13162.1.
RefSeqiNP_001287683.1. NM_001300754.1.
NP_001287685.1. NM_001300756.1.
UniGeneiHs.546482.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503103; ENSP00000425385; ENSG00000164038.
GeneIDi133308.
KEGGihsa:133308.
UCSCiuc011cex.2. human.

Organism-specific databases

CTDi133308.
HGNCiHGNC:25143. SLC9B2.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000013285.
HOGENOMiHOG000060325.
HOVERGENiHBG108184.

Miscellaneous databases

ChiTaRSiSLC9B2. human.
GenomeRNAii133308.

Gene expression databases

ExpressionAtlasiB7Z676. baseline and differential.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR030187. NHA2.
[Graphical view]
PANTHERiPTHR31102:SF6. PTHR31102:SF6. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiB7Z676_HUMAN
AccessioniPrimary (citable) accession number: B7Z676
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.