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Protein
Submitted name:

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Ankyrin-2Imported
Submitted name:
cDNA FLJ61595, highly similar to Ankyrin-2Imported
Gene namesi
Name:ANK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:493. ANK2.

PTM / Processingi

Proteomic databases

EPDiB7Z651.
MaxQBiB7Z651.
PaxDbiB7Z651.

Expressioni

Gene expression databases

ExpressionAtlasiB7Z651. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349588.

Structurei

3D structure databases

ProteinModelPortaliB7Z651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 792784ANK_REP_REGIONInterPro annotationAdd
BLAST
Domaini945 – 1085141ZU5InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 20 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000012873.
HOVERGENiHBG004234.
OrthoDBiEOG7P02H2.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR030301. Ankyrin-B.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000906. ZU5_dom.
[Graphical view]
PANTHERiPTHR24123:SF17. PTHR24123:SF17. 2 hits.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 7 hits.
PF00791. ZU5. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 23 hits.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B7Z651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA
60 70 80 90 100
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA
110 120 130 140 150
NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL
160 170 180 190 200
QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL LQNDHNADVQ
210 220 230 240 250
SKMMVNRTTE SGFTPLHIAA HYGNVNVATL LLNRGAAVDF TARNGITPLH
260 270 280 290 300
VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH DQVVELLLER
310 320 330 340 350
GAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQHKAPVDDV TLDYLTALHV
360 370 380 390 400
AAHCGHYRVT KLLLDKRANP NARALNGFTP LHIACKKNRI KVMELLVKYG
410 420 430 440 450
ASIQAITESG LTPIHVAAFM GHLNIVLLLL QNGASPDVTN IRGETALHMA
460 470 480 490 500
ARAGQVEVVR CLLRNGALVD ARAREEQTPL HIASRLGKTE IVQLLLQHMA
510 520 530 540 550
HPDAATTNGY TPLHISAREG QVDVASVLLE AGAAHSLATK KGFTPLHVAA
560 570 580 590 600
KYGSLDVAKL LLQRRAAADS AGKNGLTPLH VAAHYDNQKV ALLLLEKGAS
610 620 630 640 650
PHATAKNGYT PLHIAAKKNQ MQIASTLLNY GAETNIVTKQ GVTPLHLASQ
660 670 680 690 700
EGHTDMVTLL LDKGANIHMS TKSGLTSLHL AAQEDKVNVA DILTKHGADQ
710 720 730 740 750
DAHTKLGYTP LIVACHYGNV KMVNFLLKQG ANVNAKTKNG YTPLHQAAQQ
760 770 780 790 800
GHTHIINVLL QHGAKPNATT ANGNTALAIA KRLGYISVVD TLKVVTEEVT
810 820 830 840 850
TTTTTITEKH KLNVPETMTE VLDVSDEEGD DTMTGDGGEY LRPEDLKELG
860 870 880 890 900
DDSLPSSQFL DGMNYLRYSL EGGRSDSLRS FSSDRSHTLS HASYLRDSAV
910 920 930 940 950
MDDSVVIPSH QVSTLAKEAE RNSYRLSWGT ENLDNVALSS SPIHSGFLVS
960 970 980 990 1000
FMVDARGGAM RGCRHNGLRI IIPPRKCTAP TRVTCRLVKR HRLATMPPMV
1010 1020 1030 1040 1050
EGEGLASRLI EVGPSGAQFL GKLHLPTAPP PLNEGESLVS RILQLGPPGT
1060 1070 1080 1090 1100
KFLGPVIVEI PHFAALRGKE RELVVLRSEN GDSWKEHFCD YTEDELNEIL
1110
NGMDEVLDSP EDLE
Length:1,114
Mass (Da):119,906
Last modified:March 3, 2009 - v1
Checksum:iB2B47487854727F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1114 – 11141Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA. No translation available.
AC017007 Genomic DNA. No translation available.
AC093617 Genomic DNA. No translation available.
AC093879 Genomic DNA. No translation available.
AC093900 Genomic DNA. No translation available.
AC108042 Genomic DNA. No translation available.
AK299815 mRNA. Translation: BAH13137.1.
UniGeneiHs.620557.

Genome annotation databases

EnsembliENST00000503271; ENSP00000423799; ENSG00000145362.
UCSCiuc062zcx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA. No translation available.
AC017007 Genomic DNA. No translation available.
AC093617 Genomic DNA. No translation available.
AC093879 Genomic DNA. No translation available.
AC093900 Genomic DNA. No translation available.
AC108042 Genomic DNA. No translation available.
AK299815 mRNA. Translation: BAH13137.1.
UniGeneiHs.620557.

3D structure databases

ProteinModelPortaliB7Z651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349588.

Proteomic databases

EPDiB7Z651.
MaxQBiB7Z651.
PaxDbiB7Z651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503271; ENSP00000423799; ENSG00000145362.
UCSCiuc062zcx.1. human.

Organism-specific databases

HGNCiHGNC:493. ANK2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000012873.
HOVERGENiHBG004234.
OrthoDBiEOG7P02H2.

Miscellaneous databases

ChiTaRSiANK2. human.
NextBioi35479882.

Gene expression databases

ExpressionAtlasiB7Z651. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR030301. Ankyrin-B.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000906. ZU5_dom.
[Graphical view]
PANTHERiPTHR24123:SF17. PTHR24123:SF17. 2 hits.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 7 hits.
PF00791. ZU5. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 23 hits.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiB7Z651_HUMAN
AccessioniPrimary (citable) accession number: B7Z651
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.