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Protein

V-type proton ATPase subunit a

Gene

ATP6V0A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:ATP6V0A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:865. ATP6V0A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei358 – 38225HelicalUniRule annotationAdd
BLAST
Transmembranei402 – 42120HelicalUniRule annotationAdd
BLAST
Transmembranei498 – 51922HelicalUniRule annotationAdd
BLAST
Transmembranei525 – 54925HelicalUniRule annotationAdd
BLAST
Transmembranei590 – 61425HelicalUniRule annotationAdd
BLAST
Transmembranei692 – 71524HelicalUniRule annotationAdd
BLAST
Transmembranei721 – 74424HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z641.

Expressioni

Gene expression databases

BgeeiENSG00000033627.

Structurei

3D structure databases

SMRiB7Z641. Positions 10-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000004941.
HOVERGENiHBG014606.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 2 hits.
[Graphical view]
PIRSFiPIRSF001293. ATP6V0A1. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK
60 70 80 90 100
FVNEVRRCEE MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEMA
110 120 130 140 150
DPDLLEESSS LLEPSEMGRG TPLRLGFVAG VINRERIPTF ERMLWRVCRG
160 170 180 190 200
NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF FQGDQLKNRV KKICEGFRAS
210 220 230 240 250
LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW
260 270 280 290 300
FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH
310 320 330 340 350
SGSTVPSILN RMQTNQTPPT YNKTNKFTYG FQNIVDAYGI GTYREINPAP
360 370 380 390 400
YTIITFPFLF AVMFGDFGHG ILMTLFAVWM VLRESRILSQ KNENEMFSTV
410 420 430 440 450
FSGRYIILLM GVFSMYTGLI YNDCFSKSLN IFGSSWSVRP MFTYNWTEET
460 470 480 490 500
LRGNPVLQLN PALPGVFGGP YPFGIDPIWN IATNKLTFLN SFKMKMSVIL
510 520 530 540 550
GIIHMLFGVS LSLFNHIYFK KPLNIYFGFI PEIIFMTSLF GYLVILIFYK
560 570 580 590 600
WTAYDAHTSE NAPSLLIHFI NMFLFSYPES GYSMLYSGQK GIQCFLVVVA
610 620 630 640 650
LLCVPWMLLF KPLVLRRQYL RRKHLGTLNF GGIRVGNGPT EEDAEIIQHD
660 670 680 690 700
QLSTHSEDAD EFDFGDTMVH QAIHTIEYCL GCISNTASYL RLWALSLAHA
710 720 730 740 750
QLSEVLWTMV IHIGLSVKSL AGGLVLFFFF TAFATLTVAI LLIMEGLSAF
760 770 780
LHALRLHWVE FQNKFYSGTG FKFLPFSFEH IREGKFEE
Length:788
Mass (Da):90,500
Last modified:March 3, 2009 - v1
Checksum:i6D82730FDDC0E60B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067852 Genomic DNA. No translation available.
AC107993 Genomic DNA. No translation available.
AK299784 mRNA. Translation: BAH13127.1.
UniGeneiHs.463074.

Genome annotation databases

EnsembliENST00000537728; ENSP00000443991; ENSG00000033627.
UCSCiuc010wgk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067852 Genomic DNA. No translation available.
AC107993 Genomic DNA. No translation available.
AK299784 mRNA. Translation: BAH13127.1.
UniGeneiHs.463074.

3D structure databases

SMRiB7Z641. Positions 10-294.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB7Z641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537728; ENSP00000443991; ENSG00000033627.
UCSCiuc010wgk.3. human.

Organism-specific databases

HGNCiHGNC:865. ATP6V0A1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000004941.
HOVERGENiHBG014606.

Miscellaneous databases

ChiTaRSiATP6V0A1. human.

Gene expression databases

BgeeiENSG00000033627.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 2 hits.
[Graphical view]
PIRSFiPIRSF001293. ATP6V0A1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z641_HUMAN
AccessioniPrimary (citable) accession number: B7Z641
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.