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Protein

V-type proton ATPase subunit a

Gene

ATP6V0A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:ATP6V0A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000033627.14.
HGNCiHGNC:865. ATP6V0A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei358 – 382HelicalUniRule annotationAdd BLAST25
Transmembranei402 – 421HelicalUniRule annotationAdd BLAST20
Transmembranei498 – 519HelicalUniRule annotationAdd BLAST22
Transmembranei525 – 549HelicalUniRule annotationAdd BLAST25
Transmembranei590 – 614HelicalUniRule annotationAdd BLAST25
Transmembranei692 – 715HelicalUniRule annotationAdd BLAST24
Transmembranei721 – 744HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000033627.

PTM / Processingi

Proteomic databases

MaxQBiB7Z641.

Expressioni

Gene expression databases

BgeeiENSG00000033627.
ExpressionAtlasiB7Z641. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000004941.
HOVERGENiHBG014606.

Family and domain databases

InterProiView protein in InterPro
IPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiView protein in Pfam
PF01496. V_ATPase_I. 2 hits.
PIRSFiPIRSF001293. ATP6V0A1. 2 hits.

Sequencei

Sequence statusi: Complete.

B7Z641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK
60 70 80 90 100
FVNEVRRCEE MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEMA
110 120 130 140 150
DPDLLEESSS LLEPSEMGRG TPLRLGFVAG VINRERIPTF ERMLWRVCRG
160 170 180 190 200
NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF FQGDQLKNRV KKICEGFRAS
210 220 230 240 250
LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW
260 270 280 290 300
FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH
310 320 330 340 350
SGSTVPSILN RMQTNQTPPT YNKTNKFTYG FQNIVDAYGI GTYREINPAP
360 370 380 390 400
YTIITFPFLF AVMFGDFGHG ILMTLFAVWM VLRESRILSQ KNENEMFSTV
410 420 430 440 450
FSGRYIILLM GVFSMYTGLI YNDCFSKSLN IFGSSWSVRP MFTYNWTEET
460 470 480 490 500
LRGNPVLQLN PALPGVFGGP YPFGIDPIWN IATNKLTFLN SFKMKMSVIL
510 520 530 540 550
GIIHMLFGVS LSLFNHIYFK KPLNIYFGFI PEIIFMTSLF GYLVILIFYK
560 570 580 590 600
WTAYDAHTSE NAPSLLIHFI NMFLFSYPES GYSMLYSGQK GIQCFLVVVA
610 620 630 640 650
LLCVPWMLLF KPLVLRRQYL RRKHLGTLNF GGIRVGNGPT EEDAEIIQHD
660 670 680 690 700
QLSTHSEDAD EFDFGDTMVH QAIHTIEYCL GCISNTASYL RLWALSLAHA
710 720 730 740 750
QLSEVLWTMV IHIGLSVKSL AGGLVLFFFF TAFATLTVAI LLIMEGLSAF
760 770 780
LHALRLHWVE FQNKFYSGTG FKFLPFSFEH IREGKFEE
Length:788
Mass (Da):90,500
Last modified:March 3, 2009 - v1
Checksum:i6D82730FDDC0E60B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067852 Genomic DNA. No translation available.
AC107993 Genomic DNA. No translation available.
AK299784 mRNA. Translation: BAH13127.1.
UniGeneiHs.463074.

Genome annotation databases

EnsembliENST00000537728; ENSP00000443991; ENSG00000033627.
UCSCiuc010wgk.3. human.

Similar proteinsi

Entry informationi

Entry nameiB7Z641_HUMAN
AccessioniPrimary (citable) accession number: B7Z641
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported