B7Z5R1 (B7Z5R1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
RAC-alpha serine/threonine-protein kinase Ensembl ENSP00000443897

Submitted name:
cDNA FLJ53606, highly similar to RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) EMBL BAH12997.1

Gene names

Name:

AKT1 Ensembl ENSP00000443897

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAH12997.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS000961
Sequence similarities	Contains 1 AGC-kinase C-terminal domain. SAAS SAAS000961

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS000961 RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS000961 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara anagen Inferred from electronic annotation. Source: Compara apoptotic mitochondrial changes Inferred from electronic annotation. Source: Compara cell projection organization Inferred from electronic annotation. Source: Compara cellular response to epidermal growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to hypoxia Inferred from electronic annotation. Source: Compara cellular response to insulin stimulus Inferred from electronic annotation. Source: Compara germ cell development Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara glucose transport Inferred from electronic annotation. Source: Compara glycogen biosynthetic process Inferred from electronic annotation. Source: Compara glycogen cell differentiation involved in embryonic placenta development Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara labyrinthine layer blood vessel development Inferred from electronic annotation. Source: Compara maternal placenta development Inferred from electronic annotation. Source: Compara negative regulation of JNK cascade Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell size Inferred from electronic annotation. Source: Compara negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of protein kinase activity Inferred from electronic annotation. Source: Compara negative regulation of release of cytochrome c from mitochondria Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara peripheral nervous system myelin maintenance Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of sodium ion transport Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of vasoconstriction Inferred from electronic annotation. Source: Compara protein catabolic process Inferred from electronic annotation. Source: Compara protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara protein ubiquitination Inferred from electronic annotation. Source: Compara regulation of cell migration Inferred from electronic annotation. Source: Compara regulation of neuron projection development Inferred from electronic annotation. Source: Compara regulation of protein localization Inferred from electronic annotation. Source: Compara response to food Inferred from electronic annotation. Source: Compara striated muscle cell differentiation Inferred from electronic annotation. Source: Compara translation Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara lamellipodium Inferred from electronic annotation. Source: Compara microtubule cytoskeleton Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA spindle Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z5R1 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 671C0EB4BDF8F45F	FASTA	418	48,347
	10 20 30 40 50 60 MKTERPRPNT FIIRCLQWTT VIERTFHVET PEEREEWTTA IQTVADGLKK QEEEEMDFRS 70 80 90 100 110 120 GSPSDNSGAE EMEVSLAKPK HRVTMNEFEY LKLLGKGTFG KVILVKEKAT GRYYAMKILK 130 140 150 160 170 180 KEVIVAKDEV AHTLTENRVL QNSRHPFLTA LKYSFQTHDR LCFVMEYANG GELFFHLSRE 190 200 210 220 230 240 RVFSEDRARF YGAEIVSALD YLHSEKNVVY RDLKLENLML DKDGHIKITD FGLCKEGIKD 250 260 270 280 290 300 GATMKTFCGT PEYLAPEVLE DNDYGRAVDW WGLGVVMYEM MCGRLPFYNQ DHEKLFELIL 310 320 330 340 350 360 MEEIRFPRTL GPEAKSLLSG LLKKDPKQRL GGGSEDAKEI MQHRFFAGIV WQHVYEKKLS 370 380 390 400 410 PPFKPQVTSE TDTRYFDEEF TAQMITITPP DQDDSMECVD SERRPHFPQF SYSASGTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL583722 Genomic DNA. No translation available. AL590327 Genomic DNA. No translation available. AK299310 mRNA. Translation: BAH12997.1.
IPI	IPI01009564.
UniGene	Hs.525622.
3D structure databases
SMR	B7Z5R1. Positions 1-415.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000544168; ENSP00000443897; ENSG00000142208.
Organism-specific databases
HGNC	HGNC:391. AKT1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG108317.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR011993. PH_like_dom. IPR017892. Pkinase_C. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	AKT1. human.
NextBio	35479782.

Entry information

Entry name

B7Z5R1_HUMAN

Accession

Primary (citable) accession number: B7Z5R1

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.