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B7Z5R1

- B7Z5R1_HUMAN

UniProt

B7Z5R1 - B7Z5R1_HUMAN

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Protein
Submitted name:

RAC-alpha serine/threonine-protein kinase

Gene
AKT1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. aging Source: Ensembl
  2. anagen Source: Ensembl
  3. apoptotic mitochondrial changes Source: Ensembl
  4. cell projection organization Source: Ensembl
  5. cellular response to epidermal growth factor stimulus Source: Ensembl
  6. cellular response to hypoxia Source: Ensembl
  7. cellular response to insulin stimulus Source: Ensembl
  8. cellular response to mechanical stimulus Source: Ensembl
  9. execution phase of apoptosis Source: Ensembl
  10. germ cell development Source: Ensembl
  11. glucose homeostasis Source: Ensembl
  12. glucose metabolic process Source: Ensembl
  13. glucose transport Source: Ensembl
  14. glycogen biosynthetic process Source: Ensembl
  15. glycogen cell differentiation involved in embryonic placenta development Source: Ensembl
  16. hyaluronan metabolic process Source: Ensembl
  17. inflammatory response Source: Ensembl
  18. labyrinthine layer blood vessel development Source: Ensembl
  19. maternal placenta development Source: Ensembl
  20. negative regulation of apoptotic process Source: Ensembl
  21. negative regulation of cell size Source: Ensembl
  22. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  23. negative regulation of JNK cascade Source: Ensembl
  24. negative regulation of protein kinase activity Source: Ensembl
  25. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
  26. osteoblast differentiation Source: Ensembl
  27. peptidyl-serine phosphorylation Source: Ensembl
  28. peripheral nervous system myelin maintenance Source: Ensembl
  29. positive regulation of apoptotic process Source: Ensembl
  30. positive regulation of cell growth Source: Ensembl
  31. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  32. positive regulation of sodium ion transport Source: Ensembl
  33. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  34. positive regulation of vasoconstriction Source: Ensembl
  35. protein catabolic process Source: Ensembl
  36. protein kinase B signaling Source: Ensembl
  37. protein ubiquitination Source: Ensembl
  38. regulation of cell migration Source: Ensembl
  39. regulation of neuron projection development Source: Ensembl
  40. regulation of protein localization Source: Ensembl
  41. response to food Source: Ensembl
  42. striated muscle cell differentiation Source: Ensembl
  43. translation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
RAC-alpha serine/threonine-protein kinaseImported
Submitted name:
cDNA FLJ53606, highly similar to RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)Imported
Gene namesi
Name:AKT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:391. AKT1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. microtubule cytoskeleton Source: HPA
  3. nucleus Source: HPA
  4. spindle Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliB7Z5R1.
SMRiB7Z5R1. Positions 1-415.

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotations

Phylogenomic databases

HOVERGENiHBG108317.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z5R1-1 [UniParc]FASTAAdd to Basket

« Hide

MKTERPRPNT FIIRCLQWTT VIERTFHVET PEEREEWTTA IQTVADGLKK    50
QEEEEMDFRS GSPSDNSGAE EMEVSLAKPK HRVTMNEFEY LKLLGKGTFG 100
KVILVKEKAT GRYYAMKILK KEVIVAKDEV AHTLTENRVL QNSRHPFLTA 150
LKYSFQTHDR LCFVMEYANG GELFFHLSRE RVFSEDRARF YGAEIVSALD 200
YLHSEKNVVY RDLKLENLML DKDGHIKITD FGLCKEGIKD GATMKTFCGT 250
PEYLAPEVLE DNDYGRAVDW WGLGVVMYEM MCGRLPFYNQ DHEKLFELIL 300
MEEIRFPRTL GPEAKSLLSG LLKKDPKQRL GGGSEDAKEI MQHRFFAGIV 350
WQHVYEKKLS PPFKPQVTSE TDTRYFDEEF TAQMITITPP DQDDSMECVD 400
SERRPHFPQF SYSASGTA 418
Length:418
Mass (Da):48,347
Last modified:March 3, 2009 - v1
Checksum:i671C0EB4BDF8F45F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583722 Genomic DNA. No translation available.
AL590327 Genomic DNA. No translation available.
AK299310 mRNA. Translation: BAH12997.1.
UniGeneiHs.525622.

Genome annotation databases

EnsembliENST00000544168; ENSP00000443897; ENSG00000142208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583722 Genomic DNA. No translation available.
AL590327 Genomic DNA. No translation available.
AK299310 mRNA. Translation: BAH12997.1 .
UniGenei Hs.525622.

3D structure databases

ProteinModelPortali B7Z5R1.
SMRi B7Z5R1. Positions 1-415.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000544168 ; ENSP00000443897 ; ENSG00000142208 .

Organism-specific databases

HGNCi HGNC:391. AKT1.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG108317.

Miscellaneous databases

ChiTaRSi AKT1. human.
NextBioi 35479782.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
SMARTi SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7Z5R1_HUMAN
AccessioniPrimary (citable) accession number: B7Z5R1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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