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Protein

Mothers against decapentaplegic homolog

Gene

SMAD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:SMAD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:6768. SMAD2.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Nucleus SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei403 – 427HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, Membrane, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175387.

PTM / Processingi

Proteomic databases

MaxQBiB7Z5N5.
PeptideAtlasiB7Z5N5.
PRIDEiB7Z5N5.

Expressioni

Gene expression databases

BgeeiENSG00000175387.
ExpressionAtlasiB7Z5N5. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiB7Z5N5. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliB7Z5N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 146MH1 (MAD homology 1)InterPro annotationAdd BLAST137
Domaini244 – 431MH2 (MAD homology 2)InterPro annotationAdd BLAST188

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation
Contains 1 MH1 (MAD homology 1) domain.UniRule annotation
Contains 1 MH2 (MAD homology 2) domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119091.
HOGENOMiHOG000286018.
HOVERGENiHBG053353.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z5N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK
60 70 80 90 100
KLKKTGRLDE LEKAITTQNC NTKCVTIPRS LDGRLQVSHR KGLPHVIYCR
110 120 130 140 150
LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV
160 170 180 190 200
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG
210 220 230 240 250
ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY
260 270 280 290 300
ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR
310 320 330 340 350
HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC
360 370 380 390 400
NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRYEI
410 420 430
HIWFLNFHSV IMFHCILAYS GVHLYLFSMR L
Length:431
Mass (Da):48,669
Last modified:March 3, 2009 - v1
Checksum:iAB3BEA35AACAECDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026898 Genomic DNA. No translation available.
AC120349 Genomic DNA. No translation available.
AK299218 mRNA. Translation: BAH12971.1.
RefSeqiNP_001129409.1. NM_001135937.2.
UniGeneiHs.12253.
Hs.705764.
Hs.741342.

Genome annotation databases

EnsembliENST00000591214; ENSP00000467075; ENSG00000175387.
GeneIDi4087.
UCSCiuc010xdd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026898 Genomic DNA. No translation available.
AC120349 Genomic DNA. No translation available.
AK299218 mRNA. Translation: BAH12971.1.
RefSeqiNP_001129409.1. NM_001135937.2.
UniGeneiHs.12253.
Hs.705764.
Hs.741342.

3D structure databases

ProteinModelPortaliB7Z5N5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7Z5N5. 1 interactor.

Proteomic databases

MaxQBiB7Z5N5.
PeptideAtlasiB7Z5N5.
PRIDEiB7Z5N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000591214; ENSP00000467075; ENSG00000175387.
GeneIDi4087.
UCSCiuc010xdd.3. human.

Organism-specific databases

CTDi4087.
HGNCiHGNC:6768. SMAD2.
OpenTargetsiENSG00000175387.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119091.
HOGENOMiHOG000286018.
HOVERGENiHBG053353.

Miscellaneous databases

ChiTaRSiSMAD2. human.
GenomeRNAii4087.

Gene expression databases

BgeeiENSG00000175387.
ExpressionAtlasiB7Z5N5. baseline and differential.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z5N5_HUMAN
AccessioniPrimary (citable) accession number: B7Z5N5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.