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Protein

Heparan-sulfate 6-O-sulfotransferase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.UniRule annotation

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferaseUniRule annotation (EC:2.8.2.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Keywords - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500286396522 – 331Heparan-sulfate 6-O-sulfotransferaseSequence analysisAdd BLAST310

Proteomic databases

MaxQBiB7Z5H6.
PeptideAtlasiB7Z5H6.

Structurei

3D structure databases

ProteinModelPortaliB7Z5H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Signal-anchorUniRule annotation, Transmembrane

Phylogenomic databases

HOVERGENiHBG083012.

Family and domain databases

InterProiView protein in InterPro
IPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
PANTHERiPTHR12812. PTHR12812. 1 hit.
PfamiView protein in Pfam
PF03567. Sulfotransfer_2. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z5H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKHNGKLL LFYLLSYQAL ASDWFYCSFN RWRIFQILDA ARNFHYITIL
60 70 80 90 100
RDPVSRYLSE WRHVQRGATW KASLHVCDGR PPTSEELPSC YTGDDWSGCP
110 120 130 140 150
LKEFMDCPYN LANNRQVRML SDLTLVGCYN LSVMPEKQRN KVLLESAKSN
160 170 180 190 200
LKHMAFFGLT EFQRKTQYLF EKTFNMNFIS PFTQYNTTRA SSVEINEEIQ
210 220 230 240 250
KRIEGLNFLD MELYSYAKDL FLQRYQFMRQ KEHQEARRKR QEQRKFLKGR
260 270 280 290 300
LLQTHFQSQG QGQSQNPNQN QSQNPNPNAN QNLTQNLMQN LTQSLSQKEN
310 320 330
RESPKQNSGK EQNDNTSNGT NDYIGSVEKW R
Length:331
Mass (Da):39,097
Last modified:March 3, 2009 - v1
Checksum:iE69BFE50779EF83B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298956 mRNA. Translation: BAH12912.1.
UniGeneiHs.385956.

Similar proteinsi

Entry informationi

Entry nameiB7Z5H6_HUMAN
AccessioniPrimary (citable) accession number: B7Z5H6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.