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Protein
Submitted name:

Tropomyosin alpha-1 chain

Gene

TPM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tropomyosin alpha-1 chainImported
Submitted name:
cDNA FLJ55130, highly similar to Rattus norvegicus tropomyosin 1, alpha (Tpm1), transcript variant 8, mRNAImported
Gene namesi
Name:TPM1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140416.19
HGNCiHGNC:12010 TPM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei254 – 273HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140416

PTM / Processingi

Proteomic databases

MaxQBiB7Z596
PeptideAtlasiB7Z596

Expressioni

Gene expression databases

BgeeiENSG00000140416

Structurei

3D structure databases

SMRiB7Z596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 223Sequence analysisAdd BLAST217

Sequence similaritiesi

Belongs to the tropomyosin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074494
HOVERGENiHBG107404

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA
60 70 80 90 100
SLNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK
110 120 130 140 150
DEEKMEIQEI QLKEAKHIAE DADRKYEEVA RKLVIIESDL ERAEERAELS
160 170 180 190 200
EGQVRQLEEQ LRIMDQTLKA LMAAEDKYSQ KEDRYEEEIK VLSDKLKEAE
210 220 230 240 250
TRAEFAERSV TKLEKSIDDL EGKILSSVFS LILMVEYQPG KTIFQFKGIH
260 270
IDTLLCTCTF FLCVLWGFSL WLLNS
Length:275
Mass (Da):31,753
Last modified:March 3, 2009 - v1
Checksum:i449EE4040F0D2CC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079328 Genomic DNA No translation available.
AK298625 mRNA Translation: BAH12832.1
RefSeqiXP_005254703.1, XM_005254646.2
UniGeneiHs.133892
Hs.602995

Genome annotation databases

EnsembliENST00000560959; ENSP00000453724; ENSG00000140416
GeneIDi7168
UCSCiuc010uif.3 human

Similar proteinsi

Entry informationi

Entry nameiB7Z596_HUMAN
AccessioniPrimary (citable) accession number: B7Z596
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health