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Protein

Nuclear factor 1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi2 – 195CTF/NF-IPROSITE-ProRule annotationAdd BLAST194

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorPROSITE-ProRule annotation, DNA-bindingPROSITE-ProRule annotation
Biological processDNA replicationPROSITE-ProRule annotation, Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiB7Z4T6.
PeptideAtlasiB7Z4T6.
PRIDEiB7Z4T6.

Expressioni

Gene expression databases

GenevisibleiB7Z4T6. HS.

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000465655.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 195CTF/NF-I DNA-bindingInterPro annotationAdd BLAST194

Sequence similaritiesi

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3663. Eukaryota.
ENOG410Y16G. LUCA.
HOVERGENiHBG006561.
KOiK09170.

Family and domain databases

InterProiView protein in InterPro
IPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
PANTHERiPTHR11492. PTHR11492. 1 hit.
PfamiView protein in Pfam
PF00859. CTF_NFI. 1 hit.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
SMARTiView protein in SMART
SM00523. DWA. 1 hit.
PROSITEiView protein in PROSITE
PS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z4T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS
60 70 80 90 100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK
110 120 130 140 150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER
160 170 180 190 200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG
210 220 230 240 250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG
260 270 280 290 300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY
310 320 330 340 350
TSPSSPTSSS RNWTEDMEGG ISSLVKKTEM DKSPFNSPSP QDSPRLSSFT
360 370 380 390 400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL
410 420 430 440 450
NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP
460 470 480 490 500
RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY

QAQSWYLG
Length:508
Mass (Da):55,691
Last modified:March 3, 2009 - v1
Checksum:i31539B8A4366F98E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297825 mRNA. Translation: BAH12672.1.
RefSeqiNP_001231931.1. NM_001245002.1.
UniGeneiHs.170131.

Genome annotation databases

GeneIDi4782.
KEGGihsa:4782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297825 mRNA. Translation: BAH12672.1.
RefSeqiNP_001231931.1. NM_001245002.1.
UniGeneiHs.170131.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000465655.

Proteomic databases

PaxDbiB7Z4T6.
PeptideAtlasiB7Z4T6.
PRIDEiB7Z4T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4782.
KEGGihsa:4782.

Organism-specific databases

CTDi4782.

Phylogenomic databases

eggNOGiKOG3663. Eukaryota.
ENOG410Y16G. LUCA.
HOVERGENiHBG006561.
KOiK09170.

Miscellaneous databases

GenomeRNAii4782.

Gene expression databases

GenevisibleiB7Z4T6. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
PANTHERiPTHR11492. PTHR11492. 1 hit.
PfamiView protein in Pfam
PF00859. CTF_NFI. 1 hit.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
SMARTiView protein in SMART
SM00523. DWA. 1 hit.
PROSITEiView protein in PROSITE
PS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z4T6_HUMAN
AccessioniPrimary (citable) accession number: B7Z4T6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 15, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.