B7Z4N8 (B7Z4N8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435
EC=3.4.19.12 RuleBase RU004435

Gene names

Name:

USP14 Ensembl ENSP00000383125

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAH12624.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z4N8 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: B57991EE5A5CCA4E	FASTA	483	54,770
	10 20 30 40 50 60 MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKGMTLLM 70 80 90 100 110 120 MGSADALPEE PSAKTVFVED MTEEQLASAM ELPCGLTNLG NTCYMNATVQ CIRSVPELKD 130 140 150 160 170 180 ALKRYAGALR ASGEMASAQY ITAALRDLFD SMDKTSSSIP PIILLQFLHM AFPQFAEKGE 190 200 210 220 230 240 QGQYLQQDAN ECWIQMMRVL QQKLEAIEDD SVKETDSSSA SAATPSKKKS LIDQFFGVEF 250 260 270 280 290 300 ETTMKCTESE EEEVTKGKEN QLQLSCFINQ EVKYLFTGLK LRLQEEITKQ SPTLQRNALY 310 320 330 340 350 360 IKSSKISRLP AYLTIQMVRF FYKEKESVNA KVLKDVKFPL MLDMYELCTP ELQEKMVSFR 370 380 390 400 410 420 SKFKDLEDKK VNQQPNTSDK KSSPQKEVKY EPFSFADDIG SNNCGYYDLQ AVLTHQGRSS 430 440 450 460 470 480 SSGHYVSWVK RKQDEWIKFD DDKVSIVTPE DILRLSGGGD WHIAYVLLYG PRRVEIMEEE SEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAH12624.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000845 Genomic DNA. No translation available. AK297605 mRNA. Translation: BAH12624.1.
IPI	IPI00872664.
UniGene	Hs.464416. Hs.707058.
3D structure databases
SMR	B7Z4N8. Positions 6-75, 87-472.
ModBase	Search...
Proteomic databases
PRIDE	B7Z4N8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000400266; ENSP00000383125; ENSG00000101557.
UCSC	uc010wyr.1. human.
Organism-specific databases
HGNC	HGNC:12612. USP14.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG054185.
Gene expression databases
ArrayExpress	B7Z4N8.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR000626. Ubiquitin. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00213. UBQ. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35479520.

Entry information

Entry name

B7Z4N8_HUMAN

Accession

Primary (citable) accession number: B7Z4N8

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.