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B7Z4N8

- B7Z4N8_HUMAN

UniProt

B7Z4N8 - B7Z4N8_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

USP14

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseUniRule annotation

    Keywords - Biological processi

    Ubl conjugation pathwayUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
    Gene namesi
    Name:USP14Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:12612. USP14.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA

    Structurei

    3D structure databases

    SMRiB7Z4N8. Positions 6-75, 87-472.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C19 family.
    Contains USP domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG054185.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7Z4N8-1 [UniParc]FASTAAdd to Basket

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    MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG    50
    GTLKGMTLLM MGSADALPEE PSAKTVFVED MTEEQLASAM ELPCGLTNLG 100
    NTCYMNATVQ CIRSVPELKD ALKRYAGALR ASGEMASAQY ITAALRDLFD 150
    SMDKTSSSIP PIILLQFLHM AFPQFAEKGE QGQYLQQDAN ECWIQMMRVL 200
    QQKLEAIEDD SVKETDSSSA SAATPSKKKS LIDQFFGVEF ETTMKCTESE 250
    EEEVTKGKEN QLQLSCFINQ EVKYLFTGLK LRLQEEITKQ SPTLQRNALY 300
    IKSSKISRLP AYLTIQMVRF FYKEKESVNA KVLKDVKFPL MLDMYELCTP 350
    ELQEKMVSFR SKFKDLEDKK VNQQPNTSDK KSSPQKEVKY EPFSFADDIG 400
    SNNCGYYDLQ AVLTHQGRSS SSGHYVSWVK RKQDEWIKFD DDKVSIVTPE 450
    DILRLSGGGD WHIAYVLLYG PRRVEIMEEE SEQ 483
    Length:483
    Mass (Da):54,770
    Last modified:March 3, 2009 - v1
    Checksum:iB57991EE5A5CCA4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000845 Genomic DNA. No translation available.
    AK297605 mRNA. Translation: BAH12624.1.
    UniGeneiHs.464416.
    Hs.707058.

    Genome annotation databases

    EnsembliENST00000400266; ENSP00000383125; ENSG00000101557.
    UCSCiuc010wyr.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000845 Genomic DNA. No translation available.
    AK297605 mRNA. Translation: BAH12624.1 .
    UniGenei Hs.464416.
    Hs.707058.

    3D structure databases

    SMRi B7Z4N8. Positions 6-75, 87-472.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000400266 ; ENSP00000383125 ; ENSG00000101557 .
    UCSCi uc010wyr.1. human.

    Organism-specific databases

    HGNCi HGNC:12612. USP14.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG054185.

    Miscellaneous databases

    NextBioi 35479520.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    3. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB7Z4N8_HUMAN
    AccessioniPrimary (citable) accession number: B7Z4N8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3