Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Long-chain-fatty-acid--CoA ligase 1

Gene

ACSL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Long-chain-fatty-acid--CoA ligase 1Imported
Submitted name:
cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3)Imported
Gene namesi
Name:ACSL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:3569. ACSL1.

Expressioni

Gene expression databases

ExpressionAtlasiB7Z3Z9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB7Z3Z9.
SMRiB7Z3Z9. Positions 10-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00690000101725.
HOGENOMiHOG000159459.
HOVERGENiHBG050452.
KOiK01897.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z3Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIVPLYDTL GNEAITYIVN KAELSLVFVD KPEKAKLLLE GVENKLIPGL
60 70 80 90 100
KIIVVMDAYG SELVERGQRC GVEVTSMKAM EDLGRANRRK PKPPAPEDLA
110 120 130 140 150
VICFTSGTTG NPKGAMVTHR NIVSDCSAFV KATENTVNPC PDDTLISFLP
160 170 180 190 200
LAHMFERVVE CVMLCHGAKI GFFQGDIRLL MDDLKVLQPT VFPVVPRLLN
210 220 230 240 250
RMFDRIFGQA NTTLKRWLLD FASKRKEAEL RSGIIRNNSL WDRLIFHKVQ
260 270 280 290 300
SSLGGRVRLM VTGAAPVSAT VLTFLRAALG CQFYEGYGQT ECTAGCCLTM
310 320 330 340 350
PGDWTAGHVG APMPCNLIKL VDVEEMNYMA AEGEGEVCVK GPNVFQGYLK
360 370 380 390 400
DPAKTAEALD KDGWLHTGDI GKWLPNGTLK IIDRKKHIFK LAQGEYIAPE
410 420 430 440 450
KIENIYMRSE PVAQVFVHGE SLQAFLIAIV VPDVETLCSW AQKRGFEGSF
460 470 480 490 500
EELCRNKDVK KAILEDMVRL GKDSGLKPFE QVKGITLHPE LFSIDNGLLT
510 520
PTMKAKRPEL RNYFRSQIDD LYSTIKV
Length:527
Mass (Da):58,586
Last modified:March 3, 2009 - v1
Checksum:i60A68BDC7386BE24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079257 Genomic DNA. No translation available.
AC084871 Genomic DNA. No translation available.
AK296550 mRNA. Translation: BAH12385.1.
RefSeqiNP_001273641.1. NM_001286712.1.
UniGeneiHs.406678.

Genome annotation databases

EnsembliENST00000454703; ENSP00000407165; ENSG00000151726.
ENST00000622937; ENSP00000485264; ENSG00000151726.
GeneIDi2180.
KEGGihsa:2180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079257 Genomic DNA. No translation available.
AC084871 Genomic DNA. No translation available.
AK296550 mRNA. Translation: BAH12385.1.
RefSeqiNP_001273641.1. NM_001286712.1.
UniGeneiHs.406678.

3D structure databases

ProteinModelPortaliB7Z3Z9.
SMRiB7Z3Z9. Positions 10-468.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454703; ENSP00000407165; ENSG00000151726.
ENST00000622937; ENSP00000485264; ENSG00000151726.
GeneIDi2180.
KEGGihsa:2180.

Organism-specific databases

CTDi2180.
HGNCiHGNC:3569. ACSL1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00690000101725.
HOGENOMiHOG000159459.
HOVERGENiHBG050452.
KOiK01897.

Miscellaneous databases

ChiTaRSiACSL1. human.
GenomeRNAii2180.
NextBioi35479355.

Gene expression databases

ExpressionAtlasiB7Z3Z9. baseline and differential.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThalamusImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7Z3Z9_HUMAN
AccessioniPrimary (citable) accession number: B7Z3Z9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 27, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.