B7Z3Z9 (B7Z3Z9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Long-chain-fatty-acid--CoA ligase 1 Ensembl ENSP00000405687 Ensembl ENSP00000407165

Submitted name:
cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) EMBL BAH12385.1

Gene names

Name:

ACSL1 Ensembl ENSP00000405687 Ensembl ENSP00000407165

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAH12385.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Ligase EMBL BAH12385.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adiponectin-mediated signaling pathway Inferred from electronic annotation. Source: Compara fatty acid transport Inferred from electronic annotation. Source: Compara long-chain fatty acid metabolic process Inferred from electronic annotation. Source: GOC positive regulation of protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara response to oleic acid Inferred from electronic annotation. Source: Compara response to organic cyclic compound Inferred from electronic annotation. Source: Compara triglyceride metabolic process Inferred from electronic annotation. Source: Compara xenobiotic catabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: Compara mitochondrial outer membrane Inferred from electronic annotation. Source: Compara peroxisomal membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	long-chain fatty acid-CoA ligase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z3Z9 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 60A68BDC7386BE24	FASTA	527	58,586
	10 20 30 40 50 60 MVIVPLYDTL GNEAITYIVN KAELSLVFVD KPEKAKLLLE GVENKLIPGL KIIVVMDAYG 70 80 90 100 110 120 SELVERGQRC GVEVTSMKAM EDLGRANRRK PKPPAPEDLA VICFTSGTTG NPKGAMVTHR 130 140 150 160 170 180 NIVSDCSAFV KATENTVNPC PDDTLISFLP LAHMFERVVE CVMLCHGAKI GFFQGDIRLL 190 200 210 220 230 240 MDDLKVLQPT VFPVVPRLLN RMFDRIFGQA NTTLKRWLLD FASKRKEAEL RSGIIRNNSL 250 260 270 280 290 300 WDRLIFHKVQ SSLGGRVRLM VTGAAPVSAT VLTFLRAALG CQFYEGYGQT ECTAGCCLTM 310 320 330 340 350 360 PGDWTAGHVG APMPCNLIKL VDVEEMNYMA AEGEGEVCVK GPNVFQGYLK DPAKTAEALD 370 380 390 400 410 420 KDGWLHTGDI GKWLPNGTLK IIDRKKHIFK LAQGEYIAPE KIENIYMRSE PVAQVFVHGE 430 440 450 460 470 480 SLQAFLIAIV VPDVETLCSW AQKRGFEGSF EELCRNKDVK KAILEDMVRL GKDSGLKPFE 490 500 510 520 QVKGITLHPE LFSIDNGLLT PTMKAKRPEL RNYFRSQIDD LYSTIKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Thalamus EMBL BAH12385.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC079257 Genomic DNA. No translation available. AC084871 Genomic DNA. No translation available. AK296550 mRNA. Translation: BAH12385.1.
IPI	IPI00982418.
UniGene	Hs.406678.
3D structure databases
SMR	B7Z3Z9. Positions 10-468.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000437665; ENSP00000405687; ENSG00000151726. ENST00000454703; ENSP00000407165; ENSG00000151726.
Organism-specific databases
HGNC	HGNC:3569. ACSL1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000159459.
HOVERGEN	HBG050452.
Gene expression databases
ArrayExpress	B7Z3Z9.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ACSL1. human.
NextBio	35479355.

Entry information

Entry name

B7Z3Z9_HUMAN

Accession

Primary (citable) accession number: B7Z3Z9

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.