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B7Z3Z9

- B7Z3Z9_HUMAN

UniProt

B7Z3Z9 - B7Z3Z9_HUMAN

Protein
Submitted name:

Long-chain-fatty-acid--CoA ligase 1

Gene

ACSL1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. long-chain fatty acid-CoA ligase activity Source: Ensembl

    GO - Biological processi

    1. adiponectin-activated signaling pathway Source: Ensembl
    2. fatty acid transport Source: Ensembl
    3. positive regulation of protein serine/threonine kinase activity Source: Ensembl
    4. response to drug Source: Ensembl
    5. response to nutrient Source: Ensembl
    6. response to oleic acid Source: Ensembl
    7. response to organic cyclic compound Source: Ensembl
    8. triglyceride metabolic process Source: Ensembl
    9. xenobiotic catabolic process Source: Ensembl

    Keywords - Molecular functioni

    LigaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Long-chain-fatty-acid--CoA ligase 1Imported
    Submitted name:
    cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3)Imported
    Gene namesi
    Name:ACSL1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3569. ACSL1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. mitochondrial outer membrane Source: Ensembl
    3. peroxisomal membrane Source: Ensembl
    4. plasma membrane Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000159459.
    HOVERGENiHBG050452.
    KOiK01897.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7Z3Z9-1 [UniParc]FASTAAdd to Basket

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    MVIVPLYDTL GNEAITYIVN KAELSLVFVD KPEKAKLLLE GVENKLIPGL    50
    KIIVVMDAYG SELVERGQRC GVEVTSMKAM EDLGRANRRK PKPPAPEDLA 100
    VICFTSGTTG NPKGAMVTHR NIVSDCSAFV KATENTVNPC PDDTLISFLP 150
    LAHMFERVVE CVMLCHGAKI GFFQGDIRLL MDDLKVLQPT VFPVVPRLLN 200
    RMFDRIFGQA NTTLKRWLLD FASKRKEAEL RSGIIRNNSL WDRLIFHKVQ 250
    SSLGGRVRLM VTGAAPVSAT VLTFLRAALG CQFYEGYGQT ECTAGCCLTM 300
    PGDWTAGHVG APMPCNLIKL VDVEEMNYMA AEGEGEVCVK GPNVFQGYLK 350
    DPAKTAEALD KDGWLHTGDI GKWLPNGTLK IIDRKKHIFK LAQGEYIAPE 400
    KIENIYMRSE PVAQVFVHGE SLQAFLIAIV VPDVETLCSW AQKRGFEGSF 450
    EELCRNKDVK KAILEDMVRL GKDSGLKPFE QVKGITLHPE LFSIDNGLLT 500
    PTMKAKRPEL RNYFRSQIDD LYSTIKV 527
    Length:527
    Mass (Da):58,586
    Last modified:March 3, 2009 - v1
    Checksum:i60A68BDC7386BE24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079257 Genomic DNA. No translation available.
    AC084871 Genomic DNA. No translation available.
    AK296550 mRNA. Translation: BAH12385.1.
    RefSeqiNP_001273641.1. NM_001286712.1.
    UniGeneiHs.406678.

    Genome annotation databases

    EnsembliENST00000454703; ENSP00000407165; ENSG00000151726.
    GeneIDi2180.
    KEGGihsa:2180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079257 Genomic DNA. No translation available.
    AC084871 Genomic DNA. No translation available.
    AK296550 mRNA. Translation: BAH12385.1 .
    RefSeqi NP_001273641.1. NM_001286712.1.
    UniGenei Hs.406678.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000454703 ; ENSP00000407165 ; ENSG00000151726 .
    GeneIDi 2180.
    KEGGi hsa:2180.

    Organism-specific databases

    CTDi 2180.
    HGNCi HGNC:3569. ACSL1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000159459.
    HOVERGENi HBG050452.
    KOi K01897.

    Miscellaneous databases

    ChiTaRSi ACSL1. human.
    GenomeRNAii 2180.
    NextBioi 35479355.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: ThalamusImported.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB7Z3Z9_HUMAN
    AccessioniPrimary (citable) accession number: B7Z3Z9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3