ACSL1

Functionⁱ

GO - Molecular functionⁱ

ligase activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	LigaseImported

Molecular function

LigaseImported

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Long-chain-fatty-acid--CoA ligase 1Imported Submitted name: cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3)Imported
Gene namesⁱ	Name:ACSL1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3569. ACSL1.

HGNCⁱ

HGNC:3569. ACSL1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000151726.

Bgeeⁱ

ENSG00000151726.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 391	AMP-bindingInterPro annotationAdd BLAST		391
Domainⁱ	401 – 460	AMP-binding_CInterPro annotationAdd BLAST		60

Phylogenomic databases

eggNOGⁱ	KOG1256. Eukaryota. COG1022. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000101725.
HOGENOMⁱ	HOG000159459.
HOVERGENⁱ	HBG050452.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025110. AMP-bd_C. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501. AMP-binding. 1 hit. PF13193. AMP-binding_C. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00455. AMP_BINDING. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B7Z3Z9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVIVPLYDTL GNEAITYIVN KAELSLVFVD KPEKAKLLLE GVENKLIPGL 
        60         70         80         90        100
KIIVVMDAYG SELVERGQRC GVEVTSMKAM EDLGRANRRK PKPPAPEDLA 
       110        120        130        140        150
VICFTSGTTG NPKGAMVTHR NIVSDCSAFV KATENTVNPC PDDTLISFLP 
       160        170        180        190        200
LAHMFERVVE CVMLCHGAKI GFFQGDIRLL MDDLKVLQPT VFPVVPRLLN 
       210        220        230        240        250
RMFDRIFGQA NTTLKRWLLD FASKRKEAEL RSGIIRNNSL WDRLIFHKVQ 
       260        270        280        290        300
SSLGGRVRLM VTGAAPVSAT VLTFLRAALG CQFYEGYGQT ECTAGCCLTM 
       310        320        330        340        350
PGDWTAGHVG APMPCNLIKL VDVEEMNYMA AEGEGEVCVK GPNVFQGYLK 
       360        370        380        390        400
DPAKTAEALD KDGWLHTGDI GKWLPNGTLK IIDRKKHIFK LAQGEYIAPE 
       410        420        430        440        450
KIENIYMRSE PVAQVFVHGE SLQAFLIAIV VPDVETLCSW AQKRGFEGSF 
       460        470        480        490        500
EELCRNKDVK KAILEDMVRL GKDSGLKPFE QVKGITLHPE LFSIDNGLLT 
       510        520 
PTMKAKRPEL RNYFRSQIDD LYSTIKV

Length:527

Mass (Da):58,586

Last modified:March 3, 2009 - v1

Checksum:ⁱ60A68BDC7386BE24

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC079257 Genomic DNA. No translation available. AC084871 Genomic DNA. No translation available. AK296550 mRNA. Translation: BAH12385.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001273641.1. NM_001286712.1.
UniGeneⁱ	Hs.406678.

Genome annotation databases

Ensemblⁱ	ENST00000454703; ENSP00000407165; ENSG00000151726. ENST00000622937; ENSP00000485264; ENSG00000151726.
GeneIDⁱ	2180.
UCSC genome browser More...UCSCⁱ	uc011ckm.3. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC079257 Genomic DNA. No translation available. AC084871 Genomic DNA. No translation available. AK296550 mRNA. Translation: BAH12385.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001273641.1. NM_001286712.1.
UniGeneⁱ	Hs.406678.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000454703; ENSP00000407165; ENSG00000151726. ENST00000622937; ENSP00000485264; ENSG00000151726.
GeneIDⁱ	2180.
UCSC genome browser More...UCSCⁱ	uc011ckm.3. human.

Organism-specific databases

CTDⁱ	2180.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3569. ACSL1.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1256. Eukaryota. COG1022. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000101725.
HOGENOMⁱ	HOG000159459.
HOVERGENⁱ	HBG050452.

Miscellaneous databases

ChiTaRSⁱ	ACSL1. human.
GenomeRNAiⁱ	2180.

Gene expression databases

Bgeeⁱ	ENSG00000151726.

Bgeeⁱ

ENSG00000151726.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025110. AMP-bd_C. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501. AMP-binding. 1 hit. PF13193. AMP-binding_C. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00455. AMP_BINDING. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B7Z3Z9_HUMAN
Accessionⁱ	B7Z3Z9Primary (citable) accession number: B7Z3Z9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 3, 2009
	Last sequence update:	March 3, 2009
	Last modified:	July 5, 2017
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - B7Z3Z9 (B7Z3Z9_HUMAN)

Your basket is currently empty.

Long-chain-fatty-acid--CoA ligase 1

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B7Z3Z9 (B7Z3Z9_HUMAN)

Your basket is currently empty.

Long-chain-fatty-acid--CoA ligase 1

ACSL1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ