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UniProtKB - B7Z3Z9 (B7Z3Z9_HUMAN)

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Protein
Submitted name:

Long-chain-fatty-acid--CoA ligase 1

Gene

ACSL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionLigaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Long-chain-fatty-acid--CoA ligase 1Imported
Submitted name:
cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3)Imported
Gene namesi
Name:ACSL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:3569. ACSL1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151726.

Expressioni

Gene expression databases

BgeeiENSG00000151726.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 391AMP-bindingInterPro annotationAdd BLAST391
Domaini401 – 460AMP-binding_CInterPro annotationAdd BLAST60

Phylogenomic databases

eggNOGiKOG1256. Eukaryota.
COG1022. LUCA.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000159459.
HOVERGENiHBG050452.

Family and domain databases

InterProiView protein in InterPro
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z3Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIVPLYDTL GNEAITYIVN KAELSLVFVD KPEKAKLLLE GVENKLIPGL 
        60         70         80         90        100
KIIVVMDAYG SELVERGQRC GVEVTSMKAM EDLGRANRRK PKPPAPEDLA 
       110        120        130        140        150
VICFTSGTTG NPKGAMVTHR NIVSDCSAFV KATENTVNPC PDDTLISFLP 
       160        170        180        190        200
LAHMFERVVE CVMLCHGAKI GFFQGDIRLL MDDLKVLQPT VFPVVPRLLN 
       210        220        230        240        250
RMFDRIFGQA NTTLKRWLLD FASKRKEAEL RSGIIRNNSL WDRLIFHKVQ 
       260        270        280        290        300
SSLGGRVRLM VTGAAPVSAT VLTFLRAALG CQFYEGYGQT ECTAGCCLTM 
       310        320        330        340        350
PGDWTAGHVG APMPCNLIKL VDVEEMNYMA AEGEGEVCVK GPNVFQGYLK 
       360        370        380        390        400
DPAKTAEALD KDGWLHTGDI GKWLPNGTLK IIDRKKHIFK LAQGEYIAPE 
       410        420        430        440        450
KIENIYMRSE PVAQVFVHGE SLQAFLIAIV VPDVETLCSW AQKRGFEGSF 
       460        470        480        490        500
EELCRNKDVK KAILEDMVRL GKDSGLKPFE QVKGITLHPE LFSIDNGLLT 
       510        520 
PTMKAKRPEL RNYFRSQIDD LYSTIKV
Length:527
Mass (Da):58,586
Last modified:March 3, 2009 - v1
Checksum:i60A68BDC7386BE24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079257 Genomic DNA. No translation available.
AC084871 Genomic DNA. No translation available.
AK296550 mRNA. Translation: BAH12385.1.
RefSeqiNP_001273641.1. NM_001286712.1.
UniGeneiHs.406678.

Genome annotation databases

EnsembliENST00000454703; ENSP00000407165; ENSG00000151726.
ENST00000622937; ENSP00000485264; ENSG00000151726.
GeneIDi2180.
UCSCiuc011ckm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079257 Genomic DNA. No translation available.
AC084871 Genomic DNA. No translation available.
AK296550 mRNA. Translation: BAH12385.1.
RefSeqiNP_001273641.1. NM_001286712.1.
UniGeneiHs.406678.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454703; ENSP00000407165; ENSG00000151726.
ENST00000622937; ENSP00000485264; ENSG00000151726.
GeneIDi2180.
UCSCiuc011ckm.3. human.

Organism-specific databases

CTDi2180.
HGNCiHGNC:3569. ACSL1.
OpenTargetsiENSG00000151726.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1256. Eukaryota.
COG1022. LUCA.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000159459.
HOVERGENiHBG050452.

Miscellaneous databases

ChiTaRSiACSL1. human.
GenomeRNAii2180.

Gene expression databases

BgeeiENSG00000151726.

Family and domain databases

InterProiView protein in InterPro
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z3Z9_HUMAN
AccessioniPrimary (citable) accession number: B7Z3Z9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 7, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.