UniProtKB - B7Z3Z9 (B7Z3Z9_HUMAN)
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Protein
Submitted name:
Long-chain-fatty-acid--CoA ligase 1
Gene
ACSL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ligase activity Source: UniProtKB-KW
GO - Biological processi
- metabolic process Source: InterPro
Keywordsi
Molecular function | LigaseImported |
Names & Taxonomyi
Protein namesi | Submitted name: Long-chain-fatty-acid--CoA ligase 1ImportedSubmitted name: cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3)Imported |
Gene namesi | Name:ACSL1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151726.13. |
HGNCi | HGNC:3569. ACSL1. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 391 | AMP-bindingInterPro annotationAdd BLAST | 391 | |
Domaini | 401 – 460 | AMP-binding_CInterPro annotationAdd BLAST | 60 |
Phylogenomic databases
eggNOGi | KOG1256. Eukaryota. COG1022. LUCA. |
GeneTreei | ENSGT00690000101725. |
HOGENOMi | HOG000159459. |
HOVERGENi | HBG050452. |
Family and domain databases
InterProi | View protein in InterPro IPR025110. AMP-bd_C. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. |
Pfami | View protein in Pfam PF00501. AMP-binding. 1 hit. PF13193. AMP-binding_C. 1 hit. |
PROSITEi | View protein in PROSITE PS00455. AMP_BINDING. 1 hit. |
i Sequence
Sequence statusi: Complete.
B7Z3Z9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVIVPLYDTL GNEAITYIVN KAELSLVFVD KPEKAKLLLE GVENKLIPGL
60 70 80 90 100
KIIVVMDAYG SELVERGQRC GVEVTSMKAM EDLGRANRRK PKPPAPEDLA
110 120 130 140 150
VICFTSGTTG NPKGAMVTHR NIVSDCSAFV KATENTVNPC PDDTLISFLP
160 170 180 190 200
LAHMFERVVE CVMLCHGAKI GFFQGDIRLL MDDLKVLQPT VFPVVPRLLN
210 220 230 240 250
RMFDRIFGQA NTTLKRWLLD FASKRKEAEL RSGIIRNNSL WDRLIFHKVQ
260 270 280 290 300
SSLGGRVRLM VTGAAPVSAT VLTFLRAALG CQFYEGYGQT ECTAGCCLTM
310 320 330 340 350
PGDWTAGHVG APMPCNLIKL VDVEEMNYMA AEGEGEVCVK GPNVFQGYLK
360 370 380 390 400
DPAKTAEALD KDGWLHTGDI GKWLPNGTLK IIDRKKHIFK LAQGEYIAPE
410 420 430 440 450
KIENIYMRSE PVAQVFVHGE SLQAFLIAIV VPDVETLCSW AQKRGFEGSF
460 470 480 490 500
EELCRNKDVK KAILEDMVRL GKDSGLKPFE QVKGITLHPE LFSIDNGLLT
510 520
PTMKAKRPEL RNYFRSQIDD LYSTIKV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079257 Genomic DNA. No translation available. AC084871 Genomic DNA. No translation available. AK296550 mRNA. Translation: BAH12385.1. |
RefSeqi | NP_001273641.1. NM_001286712.1. |
UniGenei | Hs.406678. |
Genome annotation databases
Ensembli | ENST00000454703; ENSP00000407165; ENSG00000151726. ENST00000622937; ENSP00000485264; ENSG00000151726. |
GeneIDi | 2180. |
UCSCi | uc011ckm.3. human. |
Similar proteinsi
Entry informationi
Entry namei | B7Z3Z9_HUMAN | |
Accessioni | B7Z3Z9Primary (citable) accession number: B7Z3Z9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | January 31, 2018 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |