ID   B7Z3P7_HUMAN            Unreviewed;       549 AA.
AC   B7Z3P7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE            EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN   Name=HDAC9 {ECO:0000313|Ensembl:ENSP00000478829.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH12283.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478829.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|EMBL:BAH12283.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thalamus {ECO:0000313|EMBL:BAH12283.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:BAH14480.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thalamus {ECO:0000313|EMBL:BAH14480.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0007829|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [5] {ECO:0000313|Ensembl:ENSP00000478829.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC         [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC         COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; EC=3.5.1.98;
CC         Evidence={ECO:0000256|ARBA:ARBA00001028};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 2
CC       subfamily. {ECO:0000256|ARBA:ARBA00007738}.
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DR   EMBL; AC002124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC002433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC074193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK296214; BAH12283.1; -; mRNA.
DR   EMBL; AK316109; BAH14480.1; -; mRNA.
DR   RefSeq; NP_001191075.1; NM_001204146.2.
DR   RefSeq; NP_001308798.1; NM_001321869.1.
DR   RefSeq; NP_001308799.1; NM_001321870.1.
DR   RefSeq; NP_001308801.1; NM_001321872.1.
DR   RefSeq; NP_001308802.1; NM_001321873.1.
DR   RefSeq; NP_001308823.1; NM_001321894.1.
DR   RefSeq; NP_001308824.1; NM_001321895.1.
DR   Antibodypedia; 6494; 729 antibodies from 39 providers.
DR   DNASU; 9734; -.
DR   Ensembl; ENST00000622668.4; ENSP00000478829.1; ENSG00000048052.25.
DR   GeneID; 9734; -.
DR   UCSC; uc011jyc.3; human.
DR   CTD; 9734; -.
DR   HGNC; HGNC:14065; HDAC9.
DR   VEuPathDB; HostDB:ENSG00000048052; -.
DR   GeneTree; ENSGT00940000160307; -.
DR   BioGRID-ORCS; 9734; 23 hits in 1183 CRISPR screens.
DR   ChiTaRS; HDAC9; human.
DR   GenomeRNAi; 9734; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000048052; Expressed in oocyte and 203 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR   CDD; cd10163; ClassIIa_HDAC9_Gln-rich-N; 1.
DR   Gene3D; 6.10.250.1550; -; 1.
DR   InterPro; IPR024643; Hist_deacetylase_Gln_rich_N.
DR   PANTHER; PTHR45364:SF12; HISTONE DEACETYLASE 9; 1.
DR   PANTHER; PTHR45364; HISTONE DEACETYLASE 9-RELATED; 1.
DR   Pfam; PF12203; HDAC4_Gln; 1.
PE   1: Evidence at protein level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteomics identification {ECO:0007829|EPD:B7Z3P7,
KW   ECO:0007829|MaxQB:B7Z3P7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          37..127
FT                   /note="Histone deacetylase glutamine rich N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12203"
FT   REGION          113..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..263
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  61130 MW;  AB5BDC0314C70741 CRC64;
     MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMMPVVDPV VREKQLQQEL LLIQQQQQIQ
     KQLLIAEFQK QHENLTRQHQ AQLQEHIKLQ QELLAIKQQQ ELLEKEQKLE QQRQEQEVER
     HRREQQLPPL RGKDRGRERA VASTEVKQKL QEFLLSKSAT KDTPTNGKNH SVSRHPKLWY
     TAAHHTSLDQ SSPPLSGTSP SYKYTLPGAQ DAKDDFPLRK TESSVSSSSP GSGPSSPNNG
     PTGSVTENET SVLPPTPHAE QMVSQQRILI HEDSMNLLSL YTSPSLPNIT LGLPAVPSQL
     NASNSLKEKQ KCETQTLRQG VPLPGQYGGS IPASSSHPHV TLEGKPPNSS HQALLQHLLL
     KEQMRQQKLL VAGGVPLHPQ SPLATKERIS PGIRGTHKLP RHRPLNRTQS APLPQSTLAQ
     LVIQQQHQQF LEKQKQYQQQ IHMNKLLSKS IEQLKQPGSH LEEAEEELQG DQAMQEDRAP
     SSGNSTRSDS SACVDDTLGQ VGAVKVKEEP VDSDEDAQIQ EMESGEQAAF MQQVIGKDLA
     PGFVIKVII
//