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Protein

40S ribosomal protein S3a

Gene

RPS3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal proteinUniRule annotationSAAS annotationImported

Keywords - Biological processi

DifferentiationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Gene namesi
Name:RPS3AUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiB7Z3M5.
PeptideAtlasiB7Z3M5.
PRIDEiB7Z3M5.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.UniRule annotation

Protein-protein interaction databases

IntActiB7Z3M5. 1 interaction.
STRINGi9606.ENSP00000346050.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S3Ae family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1628. Eukaryota.
COG1890. LUCA.
HOGENOMiHOG000105220.
HOVERGENiHBG000783.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z3M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKKKVVD PFSKKDWYDV KAPAMFNIRN IGKTLVTRTQ GTKIASDGLK
60 70 80 90 100
GRVFEVSLAD LQNDEVAFRK FKLITEDVQG KNCLTNFHGM DLTRDKMCSM
110 120 130 140 150
VKKWQTMIEA HVDVKTTDGY LLRLFCVGFT KKRNNQIRKT SYAQHQQVRQ
160 170
IRKKMMEIMT REVQTNDLKE VVNKL
Length:175
Mass (Da):20,294
Last modified:March 3, 2009 - v1
Checksum:iAF5A0F35604E6E5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296121 mRNA. Translation: BAH12261.1.
RefSeqiNP_001254628.1. NM_001267699.1.
UniGeneiHs.356572.

Genome annotation databases

GeneIDi6189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296121 mRNA. Translation: BAH12261.1.
RefSeqiNP_001254628.1. NM_001267699.1.
UniGeneiHs.356572.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7Z3M5. 1 interaction.
STRINGi9606.ENSP00000346050.

Proteomic databases

PaxDbiB7Z3M5.
PeptideAtlasiB7Z3M5.
PRIDEiB7Z3M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6189.

Organism-specific databases

CTDi6189.

Phylogenomic databases

eggNOGiKOG1628. Eukaryota.
COG1890. LUCA.
HOGENOMiHOG000105220.
HOVERGENiHBG000783.

Miscellaneous databases

GenomeRNAii6189.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThalamusImported.

Entry informationi

Entry nameiB7Z3M5_HUMAN
AccessioniPrimary (citable) accession number: B7Z3M5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 6, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.