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Protein
Submitted name:

cDNA FLJ54690, highly similar to Beta-secretase 1 (EC 3.4.23.46)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ54690, highly similar to Beta-secretase 1 (EC 3.4.23.46)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000186318.16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z3K2.

Expressioni

Gene expression databases

BgeeiENSG00000186318.
ExpressionAtlasiB7Z3K2. baseline and differential.
GenevisibleiB7Z3K2. HS.

Structurei

3D structure databases

ProteinModelPortaliB7Z3K2.
SMRiB7Z3K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 291Peptidase A1InterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000036572.
HOVERGENiHBG059578.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR009119. BACE.
IPR009120. BACE1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF408. PTHR13683:SF408. 1 hit.
PfamiView protein in Pfam
PF00026. Asp. 1 hit.
PRINTSiPR01816. BACE1.
PR01815. BACEFAMILY.
PR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z3K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPFIYLQAH FTLCSGWSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH
60 70 80 90 100
GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARL CGAGFPLNQS
110 120 130 140 150
EVLASVGGSM IIGGIDHSLY TGSLWYTPIR REWYYEVIIV RVEINGQDLK
160 170 180 190 200
MDCKEYNYDK SIVDSGTTNL RLPKKVFEAA VKSIKAASST EKFPDGFWLG
210 220 230 240 250
EQLVCWQAGT TPWNIFPVIS LYLMGEVTNQ SFRITILPQQ YLRPVEDVAT
260 270 280 290 300
SQDDCYKFAI SQSSTGTVMG AVIMEGFYVV FDRARKRIGF AVSACHVHDE
310 320 330 340 350
FRTAAVEGPF VTLDMEDCGY NIPQTDESTL MTIAYVMAAI CALFMLPLCL
360 370
MVCQWRCLRC LRQQHDDFAD DISLLK
Length:376
Mass (Da):42,160
Last modified:March 3, 2009 - v1
Checksum:i93E4D8C553E23716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296015 mRNA. Translation: BAH12238.1.
RefSeqiNP_001193978.1. NM_001207049.1.
UniGeneiHs.504003.

Genome annotation databases

GeneIDi23621.

Similar proteinsi

Entry informationi

Entry nameiB7Z3K2_HUMAN
AccessioniPrimary (citable) accession number: B7Z3K2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation