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Protein

Serine/threonine-protein phosphatase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

CalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Expressioni

Gene expression databases

BgeeiB7Z353.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354871.

Structurei

3D structure databases

ProteinModelPortaliB7Z353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG008238.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view]
PIRSFiPIRSF000912. PPEF. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 3 hits.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSTFFSFM LENYTHIHKE ELELRNQSLE SEQDMRDRWD YVDSIDVPDS
60 70 80 90 100
YNGPRLQFPL TCTDIDLLLE AFKEQQILHA HYVLEVLFET KKVLKQMPNF
110 120 130 140 150
THIQTSPSKE VTICGDLHGK LDDLFLIFYK NGLPSERNPY VFNGDFVDRG
160 170 180 190 200
KNSIEILMIL CVSFLVYPND LHLNRGNHED FMMNLRYGFT KEILHKYKLH
210 220 230 240 250
GKRILQILEE FYAWLPIGTI VDNEILVIHG GISETTDLNL LHRVERNKMK
260 270 280 290 300
SVLIPPTETN RDHDTDSKHN KVGVTFNAHG RIKTNGSPTE HLTEHEWEQI
310 320 330 340 350
IDILWSDPRG KNGCFPNTCR GGGCYFGPDV TSKILNKYQL KMLIRSHECK
360 370 380 390 400
PEGYEICHDG KVVTIFSASN YYEEGSNRGA YIKLCSGTTP RFFQYQVTKA
410 420 430 440 450
TCFQPLRQRV DTMENSAIKI LRERVISRKS DLTRAFQLQD HRKSGKLSVS
460 470 480 490 500
QWAFCMENIL GLNLPWRSLS SNLVNIDQNG NVEYMSSFQN IRIEKPVQEA
510 520 530 540 550
HSTLVETLYR YRSDLEIIFN AIDTDHSGLI SVEEFRAMWK LFSSHYNVHI
560 570 580 590
DDSQVNKLAN IMDLNKDGSI DFNEFLKAFY VVHRYEDLMK PDVTNLG
Length:597
Mass (Da):69,353
Last modified:March 3, 2009 - v1
Checksum:iED756F263ADFE77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295504 mRNA. Translation: BAH12089.1.
UniGeneiHs.211589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295504 mRNA. Translation: BAH12089.1.
UniGeneiHs.211589.

3D structure databases

ProteinModelPortaliB7Z353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008238.

Miscellaneous databases

NextBioi35479150.

Gene expression databases

BgeeiB7Z353.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view]
PIRSFiPIRSF000912. PPEF. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 3 hits.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiB7Z353_HUMAN
AccessioniPrimary (citable) accession number: B7Z353
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 24, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.