Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein phosphatase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi523 – 534PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi563 – 574PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z353
PRIDEiB7Z353

Structurei

3D structure databases

ProteinModelPortaliB7Z353
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 462EF-handInterPro annotationAdd BLAST36
Domaini510 – 545EF-handInterPro annotationAdd BLAST36
Domaini550 – 585EF-handInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0377 Eukaryota
COG0639 LUCA
HOVERGENiHBG008238

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013235 PPP_dom
IPR012008 Ser/Thr-Pase_EF-hand_contain
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00149 Metallophos, 1 hit
PF08321 PPP5, 1 hit
PIRSFiPIRSF000912 PPEF, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SM00156 PP2Ac, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSTFFSFM LENYTHIHKE ELELRNQSLE SEQDMRDRWD YVDSIDVPDS
60 70 80 90 100
YNGPRLQFPL TCTDIDLLLE AFKEQQILHA HYVLEVLFET KKVLKQMPNF
110 120 130 140 150
THIQTSPSKE VTICGDLHGK LDDLFLIFYK NGLPSERNPY VFNGDFVDRG
160 170 180 190 200
KNSIEILMIL CVSFLVYPND LHLNRGNHED FMMNLRYGFT KEILHKYKLH
210 220 230 240 250
GKRILQILEE FYAWLPIGTI VDNEILVIHG GISETTDLNL LHRVERNKMK
260 270 280 290 300
SVLIPPTETN RDHDTDSKHN KVGVTFNAHG RIKTNGSPTE HLTEHEWEQI
310 320 330 340 350
IDILWSDPRG KNGCFPNTCR GGGCYFGPDV TSKILNKYQL KMLIRSHECK
360 370 380 390 400
PEGYEICHDG KVVTIFSASN YYEEGSNRGA YIKLCSGTTP RFFQYQVTKA
410 420 430 440 450
TCFQPLRQRV DTMENSAIKI LRERVISRKS DLTRAFQLQD HRKSGKLSVS
460 470 480 490 500
QWAFCMENIL GLNLPWRSLS SNLVNIDQNG NVEYMSSFQN IRIEKPVQEA
510 520 530 540 550
HSTLVETLYR YRSDLEIIFN AIDTDHSGLI SVEEFRAMWK LFSSHYNVHI
560 570 580 590
DDSQVNKLAN IMDLNKDGSI DFNEFLKAFY VVHRYEDLMK PDVTNLG
Length:597
Mass (Da):69,353
Last modified:March 3, 2009 - v1
Checksum:iED756F263ADFE77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295504 mRNA Translation: BAH12089.1
UniGeneiHs.211589

Similar proteinsi

Entry informationi

Entry nameiB7Z353_HUMAN
AccessioniPrimary (citable) accession number: B7Z353
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health