B7Z313 (B7Z313_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog) EMBL BAH12049.1
Organism	Homo sapiens (Human) EMBL BAH12049.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	G2 phase of mitotic cell cycle Inferred from electronic annotation. Source: Compara adult locomotory behavior Inferred from electronic annotation. Source: Compara axon cargo transport Inferred from electronic annotation. Source: Compara axon midline choice point recognition Inferred from electronic annotation. Source: Compara cellular copper ion homeostasis Inferred from electronic annotation. Source: Compara cholesterol metabolic process Inferred from electronic annotation. Source: Compara collateral sprouting in absence of injury Inferred from electronic annotation. Source: Compara dendrite development Inferred from electronic annotation. Source: Compara endocytosis Inferred from electronic annotation. Source: Compara extracellular matrix organization Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara ionotropic glutamate receptor signaling pathway Inferred from electronic annotation. Source: Compara mRNA polyadenylation Inferred from electronic annotation. Source: Compara mating behavior Inferred from electronic annotation. Source: Compara negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara neuron apoptotic process Inferred from electronic annotation. Source: Compara neuron remodeling Inferred from electronic annotation. Source: Compara positive regulation of mitotic cell cycle Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara protein phosphorylation Inferred from electronic annotation. Source: Compara regulation of epidermal growth factor-activated receptor activity Inferred from electronic annotation. Source: Compara regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara regulation of protein binding Inferred from electronic annotation. Source: Compara regulation of synapse structure and activity Inferred from electronic annotation. Source: Compara regulation of translation Inferred from electronic annotation. Source: Compara response to oxidative stress Inferred from electronic annotation. Source: Compara smooth endoplasmic reticulum calcium ion homeostasis Inferred from electronic annotation. Source: Compara suckling behavior Inferred from electronic annotation. Source: Compara synaptic growth at neuromuscular junction Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara apical part of cell Inferred from electronic annotation. Source: Compara axon Inferred from electronic annotation. Source: Compara ciliary rootlet Inferred from electronic annotation. Source: Compara cytoplasmic vesicle Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: Compara neuromuscular junction Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara spindle midzone Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from electronic annotation. Source: Compara peptidase activator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z313 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 0E42419A05F5387E	FASTA	278	31,450
	10 20 30 40 50 60 MLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRSQVMT HLRVIYERMN QSLSLLYNVP 70 80 90 100 110 120 AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA LMPSLTETKT TVELLPVNGE 130 140 150 160 170 180 FSLDDLQPWH SFGADSVPAN TENEVEPVDA RPAADRGLTT RPGSGLTNIK TEEISEVKMD 190 200 210 220 230 240 AEFRHDSGYE VHHQKLVFFA EDVGSNKGAI IGLMVGGVVI ATVIVITLVM LKKKQYTSIH 250 260 270 HGVVEVDAAV TPEERHLSKM QQNGYENPTY KFFEQMQN

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Corpus callosum EMBL BAH12049.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK295373 mRNA. Translation: BAH12049.1.
IPI	IPI00394658.
UniGene	Hs.434980.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B7Z313.
Proteomic databases
PRIDE	B7Z313.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc011acg.2. human.
Phylogenomic databases
HOGENOM	HOG000232190.
HOVERGEN	HBG000051.
OrthoDB	EOG45B1F4.
Gene expression databases
ArrayExpress	B7Z313.
Bgee	B7Z313.
Family and domain databases
Gene3D	4.10.230.10. 1 hit.
InterPro	IPR008155. Amyloid_glyco. IPR013803. Amyloid_glyco_Abeta. IPR024329. Amyloid_glyco_E2_domain. IPR019745. Amyloid_glyco_intracell_CS. IPR019543. APP_amyloid_C. [Graphical view]
Pfam	PF10515. APP_amyloid. 1 hit. PF12925. APP_E2. 1 hit. PF03494. Beta-APP. 1 hit. [Graphical view]
PRINTS	PR00203. AMYLOIDA4. PR00204. BETAAMYLOID.
SUPFAM	SSF109843. SSF109843. 1 hit.
PROSITE	PS00320. A4_INTRA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35479126.

Entry information

Entry name

B7Z313_HUMAN

Accession

Primary (citable) accession number: B7Z313

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	April 3, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.