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B7Z313

- B7Z313_HUMAN

UniProt

B7Z313 - B7Z313_HUMAN

Protein
Submitted name:

cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. peptidase activator activity Source: Ensembl

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. axon cargo transport Source: Ensembl
    3. axon midline choice point recognition Source: Ensembl
    4. cellular copper ion homeostasis Source: Ensembl
    5. cholesterol metabolic process Source: Ensembl
    6. collateral sprouting in absence of injury Source: Ensembl
    7. dendrite development Source: Ensembl
    8. endocytosis Source: Ensembl
    9. extracellular matrix organization Source: Ensembl
    10. forebrain development Source: Ensembl
    11. ionotropic glutamate receptor signaling pathway Source: Ensembl
    12. mating behavior Source: Ensembl
    13. mRNA polyadenylation Source: Ensembl
    14. negative regulation of neuron differentiation Source: Ensembl
    15. neuromuscular process controlling balance Source: Ensembl
    16. neuron apoptotic process Source: Ensembl
    17. neuron remodeling Source: Ensembl
    18. positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
    19. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    20. protein phosphorylation Source: Ensembl
    21. regulation of epidermal growth factor-activated receptor activity Source: Ensembl
    22. regulation of multicellular organism growth Source: Ensembl
    23. regulation of protein binding Source: Ensembl
    24. regulation of synapse structure and activity Source: Ensembl
    25. regulation of translation Source: Ensembl
    26. response to oxidative stress Source: Ensembl
    27. smooth endoplasmic reticulum calcium ion homeostasis Source: Ensembl
    28. suckling behavior Source: Ensembl
    29. synaptic growth at neuromuscular junction Source: Ensembl
    30. visual learning Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. axon Source: Ensembl
    3. ciliary rootlet Source: Ensembl
    4. cytoplasmic vesicle Source: Ensembl
    5. Golgi apparatus Source: Ensembl
    6. integral component of membrane Source: Ensembl
    7. neuromuscular junction Source: Ensembl
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: Ensembl
    10. spindle midzone Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiB7Z313.

    Expressioni

    Gene expression databases

    ArrayExpressiB7Z313.
    BgeeiB7Z313.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000232190.
    HOVERGENiHBG000051.

    Family and domain databases

    Gene3Di4.10.230.10. 1 hit.
    InterProiIPR008155. Amyloid_glyco.
    IPR013803. Amyloid_glyco_Abeta.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR028866. APP.
    IPR019543. APP_amyloid_C.
    [Graphical view]
    PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
    PfamiPF10515. APP_amyloid. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF03494. Beta-APP. 1 hit.
    [Graphical view]
    PRINTSiPR00203. AMYLOIDA4.
    PR00204. BETAAMYLOID.
    SUPFAMiSSF109843. SSF109843. 1 hit.
    PROSITEiPS00320. A4_INTRA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7Z313-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRSQVMT HLRVIYERMN    50
    QSLSLLYNVP AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA 100
    LMPSLTETKT TVELLPVNGE FSLDDLQPWH SFGADSVPAN TENEVEPVDA 150
    RPAADRGLTT RPGSGLTNIK TEEISEVKMD AEFRHDSGYE VHHQKLVFFA 200
    EDVGSNKGAI IGLMVGGVVI ATVIVITLVM LKKKQYTSIH HGVVEVDAAV 250
    TPEERHLSKM QQNGYENPTY KFFEQMQN 278
    Length:278
    Mass (Da):31,450
    Last modified:March 3, 2009 - v1
    Checksum:i0E42419A05F5387E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295373 mRNA. Translation: BAH12049.1.
    UniGeneiHs.434980.

    Genome annotation databases

    UCSCiuc011acg.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295373 mRNA. Translation: BAH12049.1 .
    UniGenei Hs.434980.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B7Z313.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc011acg.2. human.

    Phylogenomic databases

    HOGENOMi HOG000232190.
    HOVERGENi HBG000051.

    Miscellaneous databases

    NextBioi 35479126.

    Gene expression databases

    ArrayExpressi B7Z313.
    Bgeei B7Z313.

    Family and domain databases

    Gene3Di 4.10.230.10. 1 hit.
    InterProi IPR008155. Amyloid_glyco.
    IPR013803. Amyloid_glyco_Abeta.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR028866. APP.
    IPR019543. APP_amyloid_C.
    [Graphical view ]
    PANTHERi PTHR23103:SF7. PTHR23103:SF7. 1 hit.
    Pfami PF10515. APP_amyloid. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF03494. Beta-APP. 1 hit.
    [Graphical view ]
    PRINTSi PR00203. AMYLOIDA4.
    PR00204. BETAAMYLOID.
    SUPFAMi SSF109843. SSF109843. 1 hit.
    PROSITEi PS00320. A4_INTRA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Corpus callosumImported.

    Entry informationi

    Entry nameiB7Z313_HUMAN
    AccessioniPrimary (citable) accession number: B7Z313
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.