cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)

Functionⁱ

GO - Biological processⁱ

nervous system development Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	209 – 231	HelicalSequence analysisAdd BLAST		23

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	B7Z313.
PeptideAtlas More...PeptideAtlasⁱ	B7Z313.
PRIDEⁱ	B7Z313.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 56	APP_E2InterPro annotationAdd BLAST	56
Domainⁱ	183 – 221	Beta-APPInterPro annotationAdd BLAST	39
Domainⁱ	224 – 274	APP_amyloidInterPro annotationAdd BLAST	51

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3540. Eukaryota. ENOG410ZW2A. LUCA.
HOGENOMⁱ	HOG000232190.
HOVERGENⁱ	HBG000051.

Family and domain databases

Gene3Dⁱ	4.10.230.10. 1 hit.
InterProⁱ	View protein in InterPro IPR008155. Amyloid_glyco. IPR013803. Amyloid_glyco_Abeta. IPR024329. Amyloid_glyco_E2_domain. IPR019745. Amyloid_glyco_intracell_CS. IPR028866. APP. IPR019543. APP_amyloid_C.
PANTHERⁱ	PTHR23103:SF17. PTHR23103:SF17. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10515. APP_amyloid. 1 hit. PF12925. APP_E2. 1 hit. PF03494. Beta-APP. 1 hit.
PRINTSⁱ	PR00203. AMYLOIDA4. PR00204. BETAAMYLOID.
SUPFAMⁱ	SSF109843. SSF109843. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00320. A4_INTRA. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B7Z313-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRSQVMT HLRVIYERMN 
        60         70         80         90        100
QSLSLLYNVP AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA 
       110        120        130        140        150
LMPSLTETKT TVELLPVNGE FSLDDLQPWH SFGADSVPAN TENEVEPVDA 
       160        170        180        190        200
RPAADRGLTT RPGSGLTNIK TEEISEVKMD AEFRHDSGYE VHHQKLVFFA 
       210        220        230        240        250
EDVGSNKGAI IGLMVGGVVI ATVIVITLVM LKKKQYTSIH HGVVEVDAAV 
       260        270 
TPEERHLSKM QQNGYENPTY KFFEQMQN

Length:278

Mass (Da):31,450

Last modified:March 3, 2009 - v1

Checksum:ⁱ0E42419A05F5387E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK295373 mRNA. Translation: BAH12049.1.
UniGeneⁱ	Hs.434980.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
B7Z313	P05067 A0A140VJC8 UPI0006149AC2 UPI0000112708 UPI0004DB221D O97584 UPI0000110448	Homo sapiens (Human) Macaca mulatta (Rhesus macaque)	770	UniRef100_P05067	Cluster: Amyloid beta A4 protein	8

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
B7Z313	Q5IS80 UPI0005125E2B S7PAA7 UPI0001E30655 UPI0000110A07 UPI0000110BA0 UPI000333E927 G1PHP7 UPI0003C4661E G3QD87 +82	Pan troglodytes (Chimpanzee) Myotis brandtii (Brandt's bat) Homo sapiens (Human) Echinops telfairi (Lesser hedgehog tenrec) Myotis lucifugus (Little brown bat) Gorilla gorilla gorilla (Western lowland gorilla) Cavia porcellus (Guinea pig) Bos indicus (Zebu) Bos mutus (wild yak) Microtus ochrogaster (Prairie vole) And more	770	UniRef90_Q5IS80	Cluster: Amyloid beta A4 protein	93

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
B7Z313	Q5IS80 UPI0005125E2B S7PAA7 UPI0001E30655 UPI0000110A07 UPI0000110BA0 UPI000333E927 G1PHP7 UPI0003C4661E UPI000A31A6DD +798	Pan troglodytes (Chimpanzee) Myotis brandtii (Brandt's bat) Homo sapiens (Human) Echinops telfairi (Lesser hedgehog tenrec) Myotis lucifugus (Little brown bat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Gorilla gorilla gorilla (Western lowland gorilla) Bison bison bison Orycteropus afer afer Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) And more	770	UniRef50_Q5IS80	Cluster: Amyloid beta A4 protein	809

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK295373 mRNA. Translation: BAH12049.1.
UniGeneⁱ	Hs.434980.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	B7Z313.
PeptideAtlas More...PeptideAtlasⁱ	B7Z313.
PRIDEⁱ	B7Z313.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG3540. Eukaryota. ENOG410ZW2A. LUCA.
HOGENOMⁱ	HOG000232190.
HOVERGENⁱ	HBG000051.

Family and domain databases

Gene3Dⁱ	4.10.230.10. 1 hit.
InterProⁱ	View protein in InterPro IPR008155. Amyloid_glyco. IPR013803. Amyloid_glyco_Abeta. IPR024329. Amyloid_glyco_E2_domain. IPR019745. Amyloid_glyco_intracell_CS. IPR028866. APP. IPR019543. APP_amyloid_C.
PANTHERⁱ	PTHR23103:SF17. PTHR23103:SF17. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10515. APP_amyloid. 1 hit. PF12925. APP_E2. 1 hit. PF03494. Beta-APP. 1 hit.
PRINTSⁱ	PR00203. AMYLOIDA4. PR00204. BETAAMYLOID.
SUPFAMⁱ	SSF109843. SSF109843. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00320. A4_INTRA. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B7Z313_HUMAN
Accessionⁱ	B7Z313Primary (citable) accession number: B7Z313
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 3, 2009
	Last sequence update:	March 3, 2009
	Last modified:	August 30, 2017
	This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - B7Z313 (B7Z313_HUMAN)

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cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)

Select a section on the left to see content.

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B7Z313 (B7Z313_HUMAN)

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cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ