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Protein
Submitted name:

14-3-3 protein zeta/delta

Gene

YWHAZ

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
14-3-3 protein zeta/deltaImported
Submitted name:
cDNA FLJ50142, highly similar to 14-3-3 protein zeta/delta (Protein kinase Cinhibitor protein 1)Imported
Gene namesi
Name:YWHAZImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:12855. YWHAZ.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164924.

PTM / Processingi

Proteomic databases

MaxQBiB7Z2E6.
PeptideAtlasiB7Z2E6.
PRIDEiB7Z2E6.

Expressioni

Gene expression databases

BgeeiENSG00000164924.
ExpressionAtlasiB7Z2E6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309503.

Structurei

3D structure databases

ProteinModelPortaliB7Z2E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 12214_3_3InterPro annotationAdd BLAST122

Sequence similaritiesi

Belongs to the 14-3-3 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z2E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL
60 70 80 90 100
ALNFSVFYYE ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL
110 120
LRDNLTLWTS DTQGDEAEAG EGGEN
Length:125
Mass (Da):13,985
Last modified:March 3, 2009 - v1
Checksum:iE245092E4C7BEEA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018781 Genomic DNA. No translation available.
AC027373 Genomic DNA. No translation available.
AK294647 mRNA. Translation: BAH11832.1.
UniGeneiHs.492407.

Genome annotation databases

EnsembliENST00000521309; ENSP00000429623; ENSG00000164924.
ENST00000522819; ENSP00000428775; ENSG00000164924.
UCSCiuc011lhg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018781 Genomic DNA. No translation available.
AC027373 Genomic DNA. No translation available.
AK294647 mRNA. Translation: BAH11832.1.
UniGeneiHs.492407.

3D structure databases

ProteinModelPortaliB7Z2E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309503.

Proteomic databases

MaxQBiB7Z2E6.
PeptideAtlasiB7Z2E6.
PRIDEiB7Z2E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521309; ENSP00000429623; ENSG00000164924.
ENST00000522819; ENSP00000428775; ENSG00000164924.
UCSCiuc011lhg.2. human.

Organism-specific databases

HGNCiHGNC:12855. YWHAZ.
OpenTargetsiENSG00000164924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.

Miscellaneous databases

ChiTaRSiYWHAZ. human.

Gene expression databases

BgeeiENSG00000164924.
ExpressionAtlasiB7Z2E6. baseline and differential.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z2E6_HUMAN
AccessioniPrimary (citable) accession number: B7Z2E6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.