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Protein
Submitted name:

F-box/WD repeat-containing protein 7

Gene

FBXW7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
F-box/WD repeat-containing protein 7Imported
Submitted name:
cDNA FLJ55681, highly similar to F-box/WD repeat protein 7Imported
Gene namesi
Name:FBXW7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109670.13.
HGNCiHGNC:16712. FBXW7.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501010861823 – 531Sequence analysisAdd BLAST509

Proteomic databases

MaxQBiB7Z2C8.

Expressioni

Gene expression databases

BgeeiENSG00000109670.
ExpressionAtlasiB7Z2C8. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 148F-boxInterPro annotationAdd BLAST47
Domaini200 – 483WD_REPEATS_REGIONInterPro annotationAdd BLAST284
Repeati215 – 240WDPROSITE-ProRule annotationAdd BLAST26
Repeati241 – 280WDPROSITE-ProRule annotationAdd BLAST40
Repeati281 – 320WDPROSITE-ProRule annotationAdd BLAST40
Repeati321 – 360WDPROSITE-ProRule annotationAdd BLAST40
Repeati361 – 400WDPROSITE-ProRule annotationAdd BLAST40
Repeati401 – 440WDPROSITE-ProRule annotationAdd BLAST40
Repeati444 – 483WDPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

SignalSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
ENOG410XRWX. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000236264.
HOVERGENiHBG051596.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR036047. F-box-like_dom_sf.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z2C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFFKCISLL LIWLIPGQST TGLVPCSATP TTFGDLRAAN GQGQQRRRIT
60 70 80 90 100
SVQPPTGLQE WLKMFQSWSG PEKLLALDEL IDSCEPTQVK HMMQVIEPQF
110 120 130 140 150
QRDFISLLPK ELALYVLSFL EPKDLLQAAQ TCRYWRILAE DNLLWREKCK
160 170 180 190 200
EEGIDEPLHI KRRKVIKPGF IHSPWKSAYI RQHRIDTNWR RGELKSPKVL
210 220 230 240 250
KGHDDHVITC LQFCGNRIVS GSDDNTLKVW SAVTGKCLRT LVGHTGGVWS
260 270 280 290 300
SQMRDNIIIS GSTDRTLKVW NAETGECIHT LYGHTSTVRC MHLHEKRVVS
310 320 330 340 350
GSRDATLRVW DIETGQCLHV LMGHVAAVRC VQYDGRRVVS GAYDFMVKVW
360 370 380 390 400
DPETETCLHT LQGHTNRVYS LQFDGIHVVS GSLDTSIRVW DVETGNCIHT
410 420 430 440 450
LTGHQSLTSG MELKDNILVS GNADSTVKIW DIKTGQCLQT LQGPNKHQSA
460 470 480 490 500
VTCLQFNKNF VITSSDDGTV KLWDLKTGEF IRNLVTLESG GSGGVVWRIR
510 520 530
ASNTKLVCAV GSRNGTEETK LLVLDFDVDM K
Length:531
Mass (Da):59,724
Last modified:March 3, 2009 - v1
Checksum:i11346DF035AC0F4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023424 Genomic DNA. No translation available.
AC080078 Genomic DNA. No translation available.
AK294568 mRNA. Translation: BAH11814.1.
UniGeneiHs.561245.
Hs.717081.

Genome annotation databases

EnsembliENST00000393956; ENSP00000377528; ENSG00000109670.
UCSCiuc011cih.3. human.

Similar proteinsi

Entry informationi

Entry nameiB7Z2C8_HUMAN
AccessioniPrimary (citable) accession number: B7Z2C8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported