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  1. 1
    "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Tissue: Amygdala.
    Source: UniProtKB/TrEMBL (unreviewed).
  2. 2
    "Identification of RGS2 and type V adenylyl cyclase interaction sites."
    Salim S., Sinnarajah S., Kehrl J.H., Dessauer C.W.
    J. Biol. Chem. 278:15842-15849(2003) [PubMed] [Europe PMC] [Abstract]
    Annotation: Identification of RGS2 and type V adenylyl cyclase interaction sites.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 8 other entries.

  3. 3
    "Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes."
    Bauman A.L., Soughayer J., Nguyen B.T., Willoughby D., Carnegie G.K., Wong W., Hoshi N., Langeberg L.K., Cooper D.M., Dessauer C.W., Scott J.D.
    Mol. Cell 23:925-931(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Adenylyl cyclase V and adenylyl cyclase VI interacts with A-kinase anchoring protein 79 (AKAP79) in a complex that associates with protein kinase A forming a negative feedback loop that termporally regulates cAMP production.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 7 other entries.

  4. 4
    "Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits."
    Gao X., Sadana R., Dessauer C.W., Patel T.B.
    J. Biol. Chem. 282:294-302(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: G protein betagamma subunits stimulate type V and VI adenylyl cyclasesImported.
    Source: GeneRIF:111.

    This publication is cited by 3 and mapped to 20 other entries.

  5. 5
    "Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge."
    Saxena R., Hivert M.F., Langenberg C., Tanaka T., Pankow J.S., Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson A.U., Kao W.H., Li M., Glazer N.L., Manning A.K., Luan J., Stringham H.M., Prokopenko I., Johnson T.
    , Grarup N., Boesgaard T.W., Lecoeur C., Shrader P., O'Connell J., Ingelsson E., Couper D.J., Rice K., Song K., Andreasen C.H., Dina C., Kottgen A., Le Bacquer O., Pattou F., Taneera J., Steinthorsdottir V., Rybin D., Ardlie K., Sampson M., Qi L., van Hoek M., Weedon M.N., Aulchenko Y.S., Voight B.F., Grallert H., Balkau B., Bergman R.N., Bielinski S.J., Bonnefond A., Bonnycastle L.L., Borch-Johnsen K., Bottcher Y., Brunner E., Buchanan T.A., Bumpstead S.J., Cavalcanti-Proenca C., Charpentier G., Chen Y.D., Chines P.S., Collins F.S., Cornelis M., J Crawford G., Delplanque J., Doney A., Egan J.M., Erdos M.R., Firmann M., Forouhi N.G., Fox C.S., Goodarzi M.O., Graessler J., Hingorani A., Isomaa B., Jorgensen T., Kivimaki M., Kovacs P., Krohn K., Kumari M., Lauritzen T., Levy-Marchal C., Mayor V., McAteer J.B., Meyre D., Mitchell B.D., Mohlke K.L., Morken M.A., Narisu N., Palmer C.N., Pakyz R., Pascoe L., Payne F., Pearson D., Rathmann W., Sandbaek A., Sayer A.A., Scott L.J., Sharp S.J., Sijbrands E., Singleton A., Siscovick D.S., Smith N.L., Sparso T., Swift A.J., Syddall H., Thorleifsson G., Tonjes A., Tuomi T., Tuomilehto J., Valle T.T., Waeber G., Walley A., Waterworth D.M., Zeggini E., Zhao J.H., Illig T., Wichmann H.E., Wilson J.F., van Duijn C., Hu F.B., Morris A.D., Frayling T.M., Hattersley A.T., Thorsteinsdottir U., Stefansson K., Nilsson P., Syvanen A.C., Shuldiner A.R., Walker M., Bornstein S.R., Schwarz P., Williams G.H., Nathan D.M., Kuusisto J., Laakso M., Cooper C., Marmot M., Ferrucci L., Mooser V., Stumvoll M., Loos R.J., Altshuler D., Psaty B.M., Rotter J.I., Boerwinkle E., Hansen T., Pedersen O., Florez J.C., McCarthy M.I., Boehnke M., Barroso I., Sladek R., Froguel P., Meigs J.B., Groop L., Wareham N.J., Watanabe R.M.
    Nat. Genet. 42:142-148(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with METABOLIC: two-hour glucose challenge.Imported, Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:111, GAD:600689.

    This publication is mapped to 39 other entries.

  6. 6
    "New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk."
    DIAGRAM Consortium
    Dupuis J., Langenberg C., Prokopenko I., Saxena R., Soranzo N., Jackson A.U., Wheeler E., Glazer N.L., Bouatia-Naji N., Gloyn A.L., Lindgren C.M., Magi R., Morris A.P., Randall J., Johnson T., Elliott P., Rybin D., Thorleifsson G.
    , Steinthorsdottir V., Henneman P., Grallert H., Dehghan A., Hottenga J.J., Franklin C.S., Navarro P., Song K., Goel A., Perry J.R., Egan J.M., Lajunen T., Grarup N., Sparso T., Doney A., Voight B.F., Stringham H.M., Li M., Kanoni S., Shrader P., Cavalcanti-Proenca C., Kumari M., Qi L., Timpson N.J., Gieger C., Zabena C., Rocheleau G., Ingelsson E., An P., O'Connell J., Luan J., Elliott A., McCarroll S.A., Payne F., Roccasecca R.M., Pattou F., Sethupathy P., Ardlie K., Ariyurek Y., Balkau B., Barter P., Beilby J.P., Ben-Shlomo Y., Benediktsson R., Bennett A.J., Bergmann S., Bochud M., Boerwinkle E., Bonnefond A., Bonnycastle L.L., Borch-Johnsen K., Bottcher Y., Brunner E., Bumpstead S.J., Charpentier G., Chen Y.D., Chines P., Clarke R., Coin L.J., Cooper M.N., Cornelis M., Crawford G., Crisponi L., Day I.N., de Geus E.J., Delplanque J., Dina C., Erdos M.R., Fedson A.C., Fischer-Rosinsky A., Forouhi N.G., Fox C.S., Frants R., Franzosi M.G., Galan P., Goodarzi M.O., Graessler J., Groves C.J., Grundy S., Gwilliam R., Gyllensten U., Hadjadj S., Hallmans G., Hammond N., Han X., Hartikainen A.L., Hassanali N., Hayward C., Heath S.C., Hercberg S., Herder C., Hicks A.A., Hillman D.R., Hingorani A.D., Hofman A., Hui J., Hung J., Isomaa B., Johnson P.R., Jorgensen T., Jula A., Kaakinen M., Kaprio J., Kesaniemi Y.A., Kivimaki M., Knight B., Koskinen S., Kovacs P., Kyvik K.O., Lathrop G.M., Lawlor D.A., Le Bacquer O., Lecoeur C., Li Y., Lyssenko V., Mahley R., Mangino M., Manning A.K., Martinez-Larrad M.T., McAteer J.B., McCulloch L.J., McPherson R., Meisinger C., Melzer D., Meyre D., Mitchell B.D., Morken M.A., Mukherjee S., Naitza S., Narisu N., Neville M.J., Oostra B.A., Orru M., Pakyz R., Palmer C.N., Paolisso G., Pattaro C., Pearson D., Peden J.F., Pedersen N.L., Perola M., Pfeiffer A.F., Pichler I., Polasek O., Posthuma D., Potter S.C., Pouta A., Province M.A., Psaty B.M., Rathmann W., Rayner N.W., Rice K., Ripatti S., Rivadeneira F., Roden M., Rolandsson O., Sandbaek A., Sandhu M., Sanna S., Sayer A.A., Scheet P., Scott L.J., Seedorf U., Sharp S.J., Shields B., Sigurethsson G., Sijbrands E.J., Silveira A., Simpson L., Singleton A., Smith N.L., Sovio U., Swift A., Syddall H., Syvanen A.C., Tanaka T., Thorand B., Tichet J., Tonjes A., Tuomi T., Uitterlinden A.G., van Dijk K.W., van Hoek M., Varma D., Visvikis-Siest S., Vitart V., Vogelzangs N., Waeber G., Wagner P.J., Walley A., Walters G.B., Ward K.L., Watkins H., Weedon M.N., Wild S.H., Willemsen G., Witteman J.C., Yarnell J.W., Zeggini E., Zelenika D., Zethelius B., Zhai G., Zhao J.H., Zillikens M.C., Borecki I.B., Loos R.J., Meneton P., Magnusson P.K., Nathan D.M., Williams G.H., Hattersley A.T., Silander K., Salomaa V., Smith G.D., Bornstein S.R., Schwarz P., Spranger J., Karpe F., Shuldiner A.R., Cooper C., Dedoussis G.V., Serrano-Rios M., Morris A.D., Lind L., Palmer L.J., Hu F.B., Franks P.W., Ebrahim S., Marmot M., Kao W.H., Pankow J.S., Sampson M.J., Kuusisto J., Laakso M., Hansen T., Pedersen O., Pramstaller P.P., Wichmann H.E., Illig T., Rudan I., Wright A.F., Stumvoll M., Campbell H., Wilson J.F., Bergman R.N., Buchanan T.A., Collins F.S., Mohlke K.L., Tuomilehto J., Valle T.T., Altshuler D., Rotter J.I., Siscovick D.S., Penninx B.W., Boomsma D.I., Deloukas P., Spector T.D., Frayling T.M., Ferrucci L., Kong A., Thorsteinsdottir U., Stefansson K., van Duijn C.M., Aulchenko Y.S., Cao A., Scuteri A., Schlessinger D., Uda M., Ruokonen A., Jarvelin M.R., Waterworth D.M., Vollenweider P., Peltonen L., Mooser V., Abecasis G.R., Wareham N.J., Sladek R., Froguel P., Watanabe R.M., Meigs J.B., Groop L., Boehnke M., McCarthy M.I., Florez J.C., Barroso I.
    Nat. Genet. 42:105-116(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)Imported, Associated with METABOLIC: fasting glucose-related traits.Imported.
    Source: GeneRIF:111, GAD:600661, GAD:600674.

    This publication is mapped to 114 other entries.

  7. 7
    Annotation: Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator); variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weightImported.
    Source: GeneRIF:111.

    This publication is mapped to 6 other entries.

  8. 8
    "Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people."
    Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC)
    Boesgaard T.W., Grarup N., Jorgensen T., Borch-Johnsen K., Hansen T., Pedersen O.
    Diabetologia 53:1647-1655(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:111.

    This publication is mapped to 58 other entries.

  9. 9
    "Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight."
    Andersson E.A., Pilgaard K., Pisinger C., Harder M.N., Grarup N., Faerch K., Poulsen P., Witte D.R., Jorgensen T., Vaag A., Hansen T., Pedersen O.
    Diabetologia 53:1908-1916(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Data report a novel association between the fetal ADCY5 type 2 diabetes risk allele and decreased birthweight and confirm in meta-analyses associations between decreased birthweight and the type 2 diabetes risk alleles of HHEX-IDE and CDKAL1; Observational study and meta-analysis of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:111.

    This publication is mapped to 127 other entries.

  10. 10
    "Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population."
    Fontaine-Bisson B., Renstrom F., Rolandsson O., Payne F., Hallmans G., Barroso I., Franks P.W., Barroso I., Payne F.
    Diabetologia 53:2155-2162(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)Imported.
    Source: GeneRIF:111.

    This publication is mapped to 311 other entries.

  11. 11
    "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms."
    de Miguel-Yanes J.M., Shrader P., Pencina M.J., Fox C.S., Manning A.K., Grant R.W., Dupuis J., Florez J.C., D'Agostino R.B. Sr., Cupples L.A., Meigs J.B.
    Diabetes Care 34:121-125(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association gene-gene interaction and gene-environment interaction. (HuGE Navigator)Imported.
    Source: GeneRIF:111.

    This publication is mapped to 154 other entries.

  12. 12
    "Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters."
    Early Growth Genetics Consortium
    Mook-Kanamori D.O., Marsh J.A., Warrington N.M., Taal H.R., Newnham J.P., Beilin L.J., Lye S.J., Palmer L.J., Hofman A., Steegers E.A., Pennell C.E., Jaddoe V.W.
    J. Clin. Endocrinol. Metab. 96:E810-5(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: a genetic variant of adcy5 leads to asymmetric growth restriction characterized by a relatively larger head circumference from third trimesterImported.
    Source: GeneRIF:111.

    This publication is mapped to 6 other entries.

  13. 13
    "Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY5 in Asian Indians."
    Vasan S.K., Neville M.J., Antonisamy B., Samuel P., Fall C.H., Geethanjali F.S., Thomas N., Raghupathy P., Brismar K., Karpe F.
    PLoS ONE 6:e21331-e21331(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: Data show low birth weight in Asian Indians is not due to variation near CCNL1/ADCY5 but variant ADCY5 is associated with elevated glucose/decreased insulin response which suggests a common genetic cause of low birth weight and risk of type 2 diabetes.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 6 other entries.

  14. 14
    "Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children."
    Windholz J., Kovacs P., Tonjes A., Dittrich K., Bluher S., Kiess W., Stumvoll M., Korner A.
    PLoS ONE 6:e22101-e22101(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: The role of four loci (ADCY5 GIPR GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children was investigated.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 15 other entries.

  15. 15
    "Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin."
    Wagner R., Dudziak K., Herzberg-Schafer S.A., Machicao F., Stefan N., Staiger H., Haring H.U., Fritsche A.
    PLoS ONE 6:e23639-e23639(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: The SNP in ADCY5 is implicated in defective proinsulin-to-insulin conversion and previous findings on the role of a genetic variant in MADD on proinsulin-to-insulin conversion were confirmed.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 12 other entries.

  16. 16
    "Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes."
    Rees S.D., Hydrie M.Z., O'Hare J.P., Kumar S., Shera A.S., Basit A., Barnett A.H., Kelly M.A.
    PLoS ONE 6:e24710-e24710(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: Alleles of single nucleotide polymorphisms in GLIS3 and ADCY5 may confer risk of type 2 diabetes.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 22 other entries.

  17. 17
    "Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation."
    del Puerto A., Diaz-Hernandez J.I., Tapia M., Gomez-Villafuertes R., Benitez M.J., Zhang J., Miras-Portugal M.T., Wandosell F., Diaz-Hernandez M., Garrido J.J.
    J. Cell. Sci. 125:176-188(2012) [PubMed] [Europe PMC] [Abstract]
    Annotation: results demonstrate a crosstalk between two metabotropic and one ionotropic purinergic receptor that regulates cAMP levels through adenylate cyclase 5 and modulates axonal elongation triggered by neurotropic factors and the PI3K-Akt-GSK3 pathwayImported.
    Source: GeneRIF:111.

    This publication is mapped to 8 other entries.

  18. 18
    "Genetic variants in GCKR, GIPR, ADCY5 and VPS13C and the risk of severe sulfonylurea-induced hypoglycaemia in patients with type 2 diabetes."
    Holstein J.D., Patzer O., Korner A., Stumvoll M., Kovacs P., Holstein A.
    Exp. Clin. Endocrinol. Diabetes 121:54-57(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: no detectable effect (with an OR >2.1) of the variants in GCKR GIPR ADCY5 and VPS13C on the response to sulfonylurea treatment indicating that these variants are not significantly contributing to the risk of SH in patients with T2DImported.
    Source: GeneRIF:111.

    This publication is mapped to 15 other entries.

  19. 19
    "Genetic markers of comorbid depression and alcoholism in women."
    Procopio D.O., Saba L.M., Walter H., Lesch O., Skala K., Schlaff G., Vanderlinden L., Clapp P., Hoffman P.L., Tabakoff B.
    Alcohol. Clin. Exp. Res. 37:896-904(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: Polymorphisms ADCY5 are associated with an alcohol-dependent phenotype in females which is distinguished by comorbid signs of depression.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 9 other entries.

  20. 20
    "Dynamics of Galphai1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production."
    Milde M., Rinne A., Wunder F., Engelhardt S., Bunemann M.
    Biochem. J. 454:515-523(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: AC5 by binding active Galphai1 interferes with G-protein deactivation and reassembly and thereby might sensitize its own regulation.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 7 other entries.

  21. 21
    Annotation: the functional effect of missense mutations in adenylyl cyclase 5 (ADCY5) in sporadic and inherited cases of autosomal dominant familial dyskinesia with facial myokymiaImported.
    Source: GeneRIF:111.

    This publication is mapped to 4 other entries.

  22. 22
    Annotation: Alterations in beta-cell ADCY5 expression and impaired glucose signaling thus provide a likely route through which ADCY5 gene polymorphisms influence fasting glucose levels and T2D risk while exerting more minor effects on incretin actionImported.
    Source: GeneRIF:111.

    This publication is mapped to 4 other entries.

  23. 23
    "Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells."
    Yu P., Sun M., Villar V.A., Zhang Y., Weinman E.J., Felder R.A., Jose P.A.
    Cell. Signal. 26:2521-2529(2014) [PubMed] [Europe PMC] [Abstract]
    Annotation: LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 8 other entries.

  24. 24
    "ADCY5 gene expression in adipose tissue is related to obesity in men and mice."
    Knigge A., Kloting N., Schon M.R., Dietrich A., Fasshauer M., Gartner D., Lohmann T., Dressler M., Stumvoll M., Kovacs P., Bluher M.
    PLoS ONE 10:e0120742-e0120742(2015) [PubMed] [Europe PMC] [Abstract]
    Annotation: changes in adipose tissue ADCY5 expression are related to obesity and fat distribution.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 5 other entries.

  25. 25
    "Annexin A4 is a novel direct regulator of adenylyl cyclase type 5."
    Heinick A., Husser X., Himmler K., Kirchhefer U., Nunes F., Schulte J.S., Seidl M.D., Rolfes C., Dedman J.R., Kaetzel M.A., Gerke V., Schmitz W., Muller F.U.
    FASEB J. 29:3773-3787(2015) [PubMed] [Europe PMC] [Abstract]
    Annotation: these results suggest that AnxA4 is a novel direct negative regulator of AC5 adding a new facet to the functions of annexins.Imported.
    Source: GeneRIF:111.

    This publication is mapped to 23 other entries.

1 to 25 of 30  Show