B7Z2C7 (B7Z2C7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ55968, highly similar to Adenylate cyclase type 5 (EC 4.6.1.1) EMBL BAH11813.1
Organism	Homo sapiens (Human) EMBL BAH11813.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	978 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. RuleBase RU000405

Ontologies

Keywords
Ligand	Nucleotide-binding SAAS SAAS001054
Molecular function	Lyase SAAS SAAS001054 RuleBase RU000405
Gene Ontology (GO)
Biological_process	adenosine receptor signaling pathway Inferred from electronic annotation. Source: Compara adenylate cyclase-activating dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara adenylate cyclase-inhibiting dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara cAMP biosynthetic process Inferred from electronic annotation. Source: GOC intracellular signal transduction Inferred from electronic annotation. Source: InterPro locomotory behavior Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: Compara primary cilium Inferred from electronic annotation. Source: Compara
Molecular_function	adenylate cyclase activity Inferred from electronic annotation. Source: Compara nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z2C7 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 1FF7FB611BD419A8	FASTA	978	110,064
	10 20 30 40 50 60 MAVLCNRAAF HQDHMGLACY ALIAVVLAVQ VVGLLLPQPR SASEGIWWTV FFIYTIYTLL 70 80 90 100 110 120 PVRMRAAVLS GVLLSALHLA IALRTNAQDQ FLLKQLVSNV LIFSCTNIVG VCTHYPAEVS 130 140 150 160 170 180 QRQAFQETRE CIQARLHSQR ENQQQERLLL SVLPRHVAME MKADINAKQE DMMFHKIYIQ 190 200 210 220 230 240 KHDNVSILFA DIEGFTSLAS QCTAQELVMT LNELFARFDK LAAENHCLRI KILGDCYYCV 250 260 270 280 290 300 SGLPEARADH AHCCVEMGMD MIEAISLVRE VTGVNVNMRV GIHSGRVHCG VLGLRKWQFD 310 320 330 340 350 360 VWSNDVTLAN HMEAGGKAGR IHITKATLNY LNGDYEVEPG CGGERNAYLK EHSIETFLIL 370 380 390 400 410 420 RCTQKRKEEK AMIAKMNRQR TNSIGHNPPH WGAERPFYNH LGGNQVSKEM KRMGFEDPKD 430 440 450 460 470 480 KNAQESANPE DEVDEFLGRA IDARSIDRLR SEHVRKFLLT FREPDLEKKY SKQVDDRFGA 490 500 510 520 530 540 YVACASLVFL FICFVQITIV PHSIFMLSFY LTCSLLLTLV VFVSVIYSCV KLFPSPLQTL 550 560 570 580 590 600 SRKIVRSKMN STLVGVFTIT LVFLAAFVNM FTCNSRDLLG CLAQEHNISA SQVNACHVAE 610 620 630 640 650 660 SAVNYSLGDE QGFCGSPWPN CNFPEYFTYS VLLSLLACSV FLQISCIGKL VLMLAIELIY 670 680 690 700 710 720 VLIVEVPGVT LFDNADLLVT ANAIDFFNNG TSQCPEHATK VALKVVTPII ISVFVLALYL 730 740 750 760 770 780 HAQQVESTAR LDFLWKLQAT EEKEEMEELQ AYNRRLLHNI LPKDVAAHFL ARERRNDELY 790 800 810 820 830 840 YQSCECVAVM FASIANFSEF YVELEANNEG VECLRLLNEI IADFDEIISE DRFRQLEKIK 850 860 870 880 890 900 TIGSTYMAAS GLNDSTYDKV GKTHIKALAD FAMKLMDQMK YINEHSFNNF QMKIGLNIGP 910 920 930 940 950 960 VVAGVIGARK PQYDIWGNTV NVASRMDSTG VPDRIQVTTD MYQVLAANTY QLECRGVVKV 970 KGKGEMMTYF LNGGPPLS

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Amygdala EMBL BAH11813.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK294565 mRNA. Translation: BAH11813.1.
IPI	IPI00339214.
RefSeq	NP_899200.1. NM_183357.2.
UniGene	Hs.593292.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B7Z2C7.
Protocols and materials databases
DNASU	111.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	111.
KEGG	hsa:111.
Organism-specific databases
CTD	111.
Phylogenomic databases
HOVERGEN	HBG050458.
KO	K08045.
Gene expression databases
ArrayExpress	B7Z2C7.
Bgee	B7Z2C7.
Family and domain databases
Gene3D	3.30.70.1230. 2 hits.
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Adenylate_cyclase-like. [Graphical view]
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 2 hits.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	111.
NextBio	427.

Entry information

Entry name

B7Z2C7_HUMAN

Accession

Primary (citable) accession number: B7Z2C7

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	April 3, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.