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Protein

Adenylate cyclase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.UniRule annotation

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Magnesium 1; catalyticUniRule annotation1
Metal bindingi191Magnesium 2; catalyticUniRule annotation1
Metal bindingi192Magnesium 2; via carbonyl oxygen; catalyticUniRule annotation1
Metal bindingi235Magnesium 1; catalyticUniRule annotation1
Metal bindingi235Magnesium 2; catalyticUniRule annotation1
Binding sitei279ATPUniRule annotation1
Binding sitei840ATPUniRule annotation1
Binding sitei961ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 196ATPUniRule annotation6
Nucleotide bindingi233 – 235ATPUniRule annotation3
Nucleotide bindingi914 – 916ATPUniRule annotation3
Nucleotide bindingi921 – 925ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processcAMP biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclaseUniRule annotation (EC:4.6.1.1UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 36HelicalSequence analysisAdd BLAST20
Transmembranei42 – 60HelicalSequence analysisAdd BLAST19
Transmembranei478 – 499HelicalSequence analysisAdd BLAST22
Transmembranei505 – 530HelicalSequence analysisAdd BLAST26
Transmembranei551 – 572HelicalSequence analysisAdd BLAST22
Transmembranei626 – 644HelicalSequence analysisAdd BLAST19
Transmembranei651 – 672HelicalSequence analysisAdd BLAST22
Transmembranei701 – 720HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z2C7

Expressioni

Gene expression databases

GenevisibleiB7Z2C7 HS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 313Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini788 – 927Guanylate cyclaseInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili739 – 759Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3619 Eukaryota
COG2114 LUCA
HOVERGENiHBG050458
KOiK08045

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR032628 AC_N
IPR030672 Adcy
IPR009398 Adcy_conserved_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF16214 AC_N, 1 hit
PF06327 DUF1053, 1 hit
PF00211 Guanylate_cyc, 2 hits
PIRSFiPIRSF039050 Ade_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequencei

Sequence statusi: Complete.

B7Z2C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLCNRAAF HQDHMGLACY ALIAVVLAVQ VVGLLLPQPR SASEGIWWTV
60 70 80 90 100
FFIYTIYTLL PVRMRAAVLS GVLLSALHLA IALRTNAQDQ FLLKQLVSNV
110 120 130 140 150
LIFSCTNIVG VCTHYPAEVS QRQAFQETRE CIQARLHSQR ENQQQERLLL
160 170 180 190 200
SVLPRHVAME MKADINAKQE DMMFHKIYIQ KHDNVSILFA DIEGFTSLAS
210 220 230 240 250
QCTAQELVMT LNELFARFDK LAAENHCLRI KILGDCYYCV SGLPEARADH
260 270 280 290 300
AHCCVEMGMD MIEAISLVRE VTGVNVNMRV GIHSGRVHCG VLGLRKWQFD
310 320 330 340 350
VWSNDVTLAN HMEAGGKAGR IHITKATLNY LNGDYEVEPG CGGERNAYLK
360 370 380 390 400
EHSIETFLIL RCTQKRKEEK AMIAKMNRQR TNSIGHNPPH WGAERPFYNH
410 420 430 440 450
LGGNQVSKEM KRMGFEDPKD KNAQESANPE DEVDEFLGRA IDARSIDRLR
460 470 480 490 500
SEHVRKFLLT FREPDLEKKY SKQVDDRFGA YVACASLVFL FICFVQITIV
510 520 530 540 550
PHSIFMLSFY LTCSLLLTLV VFVSVIYSCV KLFPSPLQTL SRKIVRSKMN
560 570 580 590 600
STLVGVFTIT LVFLAAFVNM FTCNSRDLLG CLAQEHNISA SQVNACHVAE
610 620 630 640 650
SAVNYSLGDE QGFCGSPWPN CNFPEYFTYS VLLSLLACSV FLQISCIGKL
660 670 680 690 700
VLMLAIELIY VLIVEVPGVT LFDNADLLVT ANAIDFFNNG TSQCPEHATK
710 720 730 740 750
VALKVVTPII ISVFVLALYL HAQQVESTAR LDFLWKLQAT EEKEEMEELQ
760 770 780 790 800
AYNRRLLHNI LPKDVAAHFL ARERRNDELY YQSCECVAVM FASIANFSEF
810 820 830 840 850
YVELEANNEG VECLRLLNEI IADFDEIISE DRFRQLEKIK TIGSTYMAAS
860 870 880 890 900
GLNDSTYDKV GKTHIKALAD FAMKLMDQMK YINEHSFNNF QMKIGLNIGP
910 920 930 940 950
VVAGVIGARK PQYDIWGNTV NVASRMDSTG VPDRIQVTTD MYQVLAANTY
960 970
QLECRGVVKV KGKGEMMTYF LNGGPPLS
Length:978
Mass (Da):110,064
Last modified:March 3, 2009 - v1
Checksum:i1FF7FB611BD419A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294565 mRNA Translation: BAH11813.1
RefSeqiNP_899200.1, NM_183357.2
UniGeneiHs.593292

Genome annotation databases

GeneIDi111
KEGGihsa:111

Similar proteinsi

Entry informationi

Entry nameiB7Z2C7_HUMAN
AccessioniPrimary (citable) accession number: B7Z2C7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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