Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Adenomatous polyposis coli protein

Gene

APC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Adenomatous polyposis coli proteinImported
Submitted name:
cDNA FLJ50140, highly similar to Adenomatous polyposis coli proteinImported
Gene namesi
Name:APCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:583. APC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z2B6.

Expressioni

Gene expression databases

BgeeiENSG00000134982.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000257430.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 17835Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2122. Eukaryota.
ENOG410XR2V. LUCA.
GeneTreeiENSGT00530000063749.
HOGENOMiHOG000033986.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 2 hits.
PTHR12607:SF11. PTHR12607:SF11. 2 hits.
PfamiPF05972. APC_15aa. 2 hits.
PF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF82931. SSF82931. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B7Z2B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYASLGSGPV APLPASVPPS VLGSWSTGGS RSCVRQETKS PGGARTSGHW
60 70 80 90 100
ASVWQEVLKQ LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK
110 120 130 140 150
MSLRSYGSRE GSVSSRSGEC SPVPMGSFPR RGFVNGSRES TGYLEELEKE
160 170 180 190 200
RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL QTDMTRRQLE
210 220 230 240 250
YEARQIRVAM EEQLGTCQDM EKRAQRSSQN KHETGSHDAE RQNEGQGVGE
260 270 280 290 300
INMATSGNGQ GSTTRMDHET ASVLSSSSTH SAPRRLTSHL GTKVEMVYSL
310 320 330 340 350
LSMLGTHDKD DMSRTLLAMS SSQDSCISMR QSGCLPLLIQ LLHGNDKDSV
360 370 380 390 400
LLGNSRGSKE ARARASAALH NIIHSQPDDK RGRREIRVLH LLEQIRAYCE
410 420 430 440 450
TCWEWQEAHE PGMDQDKNPM PAPVEHQICP AVCVLMKLSF DEEHRHAMNE
460 470 480 490 500
LGGLQAIAEL LQVDCEMYGL TNDHYSITLR RYAGMALTNL TFGDVANKAT
510 520 530 540 550
LCSMKGCMRA LVAQLKSESE DLQQVIASVL RNLSWRADVN SKKTLREVGS
560 570 580 590 600
VKALMECALE VKKESTLKSV LSALWNLSAH CTENKADICA VDGALAFLVG
610 620 630 640 650
TLTYRSQTNT LAIIESGGGI LRNVSSLIAT NEDHRQILRE NNCLQTLLQH
660 670 680 690 700
LKSHSLTIVS NACGTLWNLS ARNPKDQEAL WDMGAVSMLK NLIHSKHKMI
710 720 730 740 750
AMGSAAALRN LMANRPAKYK DANIMSPGSS LPSLHVRKQK ALEAELDAQH
760 770 780 790 800
LSETFDNIDN LSPKASHRSK QRHKQSLYGD YVFDTNRHDD NRSDNFNTGN
810 820 830 840 850
MTVLSPYLNT TVLPSSSSSR GSLDSSRSEK DRSLERERGI GLGNYHPATE
860 870 880 890 900
NPGTSSKRGL QISTTAAQIA KVMEEVSAIH TSQEDRSSGS TTELHCVTDE
910 920 930 940 950
RNALRRSSAA HTHSNTYNFT KSENSNRTCS MPYAKLEYKR SSNDSLNSVS
960 970 980 990 1000
SSDGYGKRGQ MKPSIESYSE DDESKFCSYG QYPADLAHKI HSANHMDDND
1010 1020 1030 1040 1050
GELDTPINYS LKYSDEQLNS GRQSPSQNER WARPKHIIED EIKQSEQRQS
1060 1070 1080 1090 1100
RNQSTTYPVY TESTDDKHLK FQPHFGQQEC VSPYRSRGAN GSETNRVGSN
1110 1120 1130
HGINQNVSQS LCQEDDYEDD KPTNYSERYS EEEQH
Length:1,135
Mass (Da):126,175
Last modified:March 3, 2009 - v1
Checksum:iD97C5AC3B6B835DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1135 – 11351Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008575 Genomic DNA. No translation available.
AC136500 Genomic DNA. No translation available.
AK294544 mRNA. Translation: BAH11802.1.
RefSeqiNP_001120983.2. NM_001127511.2.
UniGeneiHs.158932.

Genome annotation databases

EnsembliENST00000507379; ENSP00000423224; ENSG00000134982.
GeneIDi324.
UCSCiuc063gan.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008575 Genomic DNA. No translation available.
AC136500 Genomic DNA. No translation available.
AK294544 mRNA. Translation: BAH11802.1.
RefSeqiNP_001120983.2. NM_001127511.2.
UniGeneiHs.158932.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000257430.

Proteomic databases

PeptideAtlasiB7Z2B6.

Protocols and materials databases

DNASUi324.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507379; ENSP00000423224; ENSG00000134982.
GeneIDi324.
UCSCiuc063gan.1. human.

Organism-specific databases

CTDi324.
HGNCiHGNC:583. APC.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2122. Eukaryota.
ENOG410XR2V. LUCA.
GeneTreeiENSGT00530000063749.
HOGENOMiHOG000033986.

Miscellaneous databases

ChiTaRSiAPC. human.
GenomeRNAii324.

Gene expression databases

BgeeiENSG00000134982.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 2 hits.
PTHR12607:SF11. PTHR12607:SF11. 2 hits.
PfamiPF05972. APC_15aa. 2 hits.
PF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF82931. SSF82931. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z2B6_HUMAN
AccessioniPrimary (citable) accession number: B7Z2B6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.