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Protein
Submitted name:

Rap guanine nucleotide exchange factor 4

Gene

RAPGEF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Rap guanine nucleotide exchange factor 4Imported
Submitted name:
cDNA FLJ50956, highly similar to Rap guanine nucleotide exchange factor 4Imported
Submitted name:
cDNA FLJ61771, highly similar to Rap guanine nucleotide exchange factor 4Imported
Gene namesi
Name:RAPGEF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16626. RAPGEF4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiB7Z278. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000380271.

Structurei

3D structure databases

SMRiB7Z278. Positions 1-789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7171DEPInterPro annotationAdd
BLAST
Domaini136 – 237102Cyclic nucleotide-bindingInterPro annotationAdd
BLAST
Domaini276 – 414139N-terminal Ras-GEFInterPro annotationAdd
BLAST
Domaini552 – 789238Ras-GEFInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains N-terminal Ras-GEF domain.SAAS annotation
Contains Ras-GEF domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR031189. RAPGEF4.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR23113:SF175. PTHR23113:SF175. 2 hits.
PfamiPF00027. cNMP_binding. 1 hit.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRDRKYHLK TYRQCCVGTE LVDWMMQQTP CVHSRTQAVG MWQVLLEDGV
60 70 80 90 100
LNHVDQEHHF QDKYLFYRFL DDEHEDAPLP TEEEKKECDE ELQDTMLLLS
110 120 130 140 150
QMGPDAHMRM ILRKPPGQRT VDDLEIIYEE LLHIKALSHL STTVKRELAG
160 170 180 190 200
VLIFESHAKG GTVLFNQGEE GTSWYIILKG SVNVVIYGKG VVCTLHEGDD
210 220 230 240 250
FGKLALVNDA PRAASIVLRE DNCHFLRVDK EDFNRILRDV EANTVRLKEH
260 270 280 290 300
DQDVLVLEKV PAGNRASNQG NSQPQQKYTV MSGTPEKILE HFLETIRLEA
310 320 330 340 350
TLNEATDSVL NDFIMMHCVF MPNTQLCPAL VAHYHAQPSQ GTEQEKMDYA
360 370 380 390 400
LNNKRRVIRL VLQWAAMYGD LLQEDDVSMA FLEEFYVSVS DDARMIAALK
410 420 430 440 450
EQLPELEKIV KQISEDAKAP QKKHKVLLQQ FNTGDERAQK RQPIRGSDEV
460 470 480 490 500
LFKVYCMDHT YTTIRVPVAT SVKEVISAVA DKLGSGEGLI IVKMSSGGEK
510 520 530 540 550
VVLKPNDVSV FTTLTINGRL FACPREQFDS LTPLPEQEGP TVGTVGTFEL
560 570 580 590 600
MSSKDLAYQM TIYDWELFNC VHELELIYHT FGRHNFKKTT ANLDLFLRRF
610 620 630 640 650
NEIQFWVVTE ICLCSQLSKR VQLLKKFIKI AAHCKEYKNL NSFFAIVMGL
660 670 680 690 700
SNVAVSRLAL TWEKLPSKFK KFYAEFESLM DPSRNHRAYR LTVAKLEPPL
710 720 730 740 750
IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK MRMIANTART VRYYRSQPFN
760 770 780 790
PDAAQANKNH QDVRSYVRQL NVIDNQRTLS QMSHRLEPRR P
Length:791
Mass (Da):90,975
Last modified:March 3, 2009 - v1
Checksum:iD78EE91921EF294C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009484 Genomic DNA. No translation available.
AC018712 Genomic DNA. No translation available.
AC019046 Genomic DNA. No translation available.
AC104086 Genomic DNA. No translation available.
AK294433 mRNA. Translation: BAH11764.1.
AK294914 mRNA. Translation: BAH11923.1.
RefSeqiNP_001269830.1. NM_001282901.1.
UniGeneiHs.470646.

Genome annotation databases

EnsembliENST00000535187; ENSP00000438011; ENSG00000091428.
GeneIDi11069.
UCSCiuc010zeh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009484 Genomic DNA. No translation available.
AC018712 Genomic DNA. No translation available.
AC019046 Genomic DNA. No translation available.
AC104086 Genomic DNA. No translation available.
AK294433 mRNA. Translation: BAH11764.1.
AK294914 mRNA. Translation: BAH11923.1.
RefSeqiNP_001269830.1. NM_001282901.1.
UniGeneiHs.470646.

3D structure databases

SMRiB7Z278. Positions 1-789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000380271.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000535187; ENSP00000438011; ENSG00000091428.
GeneIDi11069.
UCSCiuc010zeh.3. human.

Organism-specific databases

CTDi11069.
HGNCiHGNC:16626. RAPGEF4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.

Miscellaneous databases

ChiTaRSiRAPGEF4. human.
GenomeRNAii11069.
NextBioi35478927.

Gene expression databases

ExpressionAtlasiB7Z278. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR031189. RAPGEF4.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR23113:SF175. PTHR23113:SF175. 2 hits.
PfamiPF00027. cNMP_binding. 1 hit.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported and BrainImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7Z278_HUMAN
AccessioniPrimary (citable) accession number: B7Z278
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.