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Protein
Submitted name:

Rap guanine nucleotide exchange factor 4

Gene

RAPGEF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rap guanine nucleotide exchange factor 4Imported
Submitted name:
cDNA FLJ50956, highly similar to Rap guanine nucleotide exchange factor 4Imported
Submitted name:
cDNA FLJ61771, highly similar to Rap guanine nucleotide exchange factor 4Imported
Gene namesi
Name:RAPGEF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000091428.17.
HGNCiHGNC:16626. RAPGEF4.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091428.

Expressioni

Gene expression databases

BgeeiENSG00000091428.
ExpressionAtlasiB7Z278. baseline and differential.

Structurei

3D structure databases

SMRiB7Z278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 71DEPInterPro annotationAdd BLAST71
Domaini136 – 237Cyclic nucleotide-bindingInterPro annotationAdd BLAST102
Domaini276 – 414N-terminal Ras-GEFInterPro annotationAdd BLAST139
Domaini552 – 789Ras-GEFInterPro annotationAdd BLAST238

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00880000137870.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRDRKYHLK TYRQCCVGTE LVDWMMQQTP CVHSRTQAVG MWQVLLEDGV
60 70 80 90 100
LNHVDQEHHF QDKYLFYRFL DDEHEDAPLP TEEEKKECDE ELQDTMLLLS
110 120 130 140 150
QMGPDAHMRM ILRKPPGQRT VDDLEIIYEE LLHIKALSHL STTVKRELAG
160 170 180 190 200
VLIFESHAKG GTVLFNQGEE GTSWYIILKG SVNVVIYGKG VVCTLHEGDD
210 220 230 240 250
FGKLALVNDA PRAASIVLRE DNCHFLRVDK EDFNRILRDV EANTVRLKEH
260 270 280 290 300
DQDVLVLEKV PAGNRASNQG NSQPQQKYTV MSGTPEKILE HFLETIRLEA
310 320 330 340 350
TLNEATDSVL NDFIMMHCVF MPNTQLCPAL VAHYHAQPSQ GTEQEKMDYA
360 370 380 390 400
LNNKRRVIRL VLQWAAMYGD LLQEDDVSMA FLEEFYVSVS DDARMIAALK
410 420 430 440 450
EQLPELEKIV KQISEDAKAP QKKHKVLLQQ FNTGDERAQK RQPIRGSDEV
460 470 480 490 500
LFKVYCMDHT YTTIRVPVAT SVKEVISAVA DKLGSGEGLI IVKMSSGGEK
510 520 530 540 550
VVLKPNDVSV FTTLTINGRL FACPREQFDS LTPLPEQEGP TVGTVGTFEL
560 570 580 590 600
MSSKDLAYQM TIYDWELFNC VHELELIYHT FGRHNFKKTT ANLDLFLRRF
610 620 630 640 650
NEIQFWVVTE ICLCSQLSKR VQLLKKFIKI AAHCKEYKNL NSFFAIVMGL
660 670 680 690 700
SNVAVSRLAL TWEKLPSKFK KFYAEFESLM DPSRNHRAYR LTVAKLEPPL
710 720 730 740 750
IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK MRMIANTART VRYYRSQPFN
760 770 780 790
PDAAQANKNH QDVRSYVRQL NVIDNQRTLS QMSHRLEPRR P
Length:791
Mass (Da):90,975
Last modified:March 3, 2009 - v1
Checksum:iD78EE91921EF294C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009484 Genomic DNA. No translation available.
AC018712 Genomic DNA. No translation available.
AC019046 Genomic DNA. No translation available.
AC104086 Genomic DNA. No translation available.
AK294433 mRNA. Translation: BAH11764.1.
AK294914 mRNA. Translation: BAH11923.1.
RefSeqiNP_001269830.1. NM_001282901.1.
UniGeneiHs.470646.

Genome annotation databases

EnsembliENST00000535187; ENSP00000438011; ENSG00000091428.
GeneIDi11069.
UCSCiuc010zeh.3. human.

Similar proteinsi

Entry informationi

Entry nameiB7Z278_HUMAN
AccessioniPrimary (citable) accession number: B7Z278
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported