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Protein
Submitted name:

cDNA FLJ50956, highly similar to Rap guanine nucleotide exchange factor 4

Gene

RAPGEF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ50956, highly similar to Rap guanine nucleotide exchange factor 4Imported
Gene namesi
Name:RAPGEF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000091428.17
HGNCiHGNC:16626 RAPGEF4

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091428

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z278
PRIDEiB7Z278

Expressioni

Gene expression databases

BgeeiENSG00000091428
ExpressionAtlasiB7Z278 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiB7Z278
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 71DEPInterPro annotationAdd BLAST71
Domaini136 – 237Cyclic nucleotide-bindingInterPro annotationAdd BLAST102
Domaini276 – 414N-terminal Ras-GEFInterPro annotationAdd BLAST139
Domaini552 – 789Ras-GEFInterPro annotationAdd BLAST238

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili396 – 416Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2378 Eukaryota
ENOG410XPX9 LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000230545
HOVERGENiHBG056985

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.840.10, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR000591 DEP_dom
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00610 DEP, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00049 DEP, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48366 SSF48366, 2 hits
SSF51206 SSF51206, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50186 DEP, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRDRKYHLK TYRQCCVGTE LVDWMMQQTP CVHSRTQAVG MWQVLLEDGV
60 70 80 90 100
LNHVDQEHHF QDKYLFYRFL DDEHEDAPLP TEEEKKECDE ELQDTMLLLS
110 120 130 140 150
QMGPDAHMRM ILRKPPGQRT VDDLEIIYEE LLHIKALSHL STTVKRELAG
160 170 180 190 200
VLIFESHAKG GTVLFNQGEE GTSWYIILKG SVNVVIYGKG VVCTLHEGDD
210 220 230 240 250
FGKLALVNDA PRAASIVLRE DNCHFLRVDK EDFNRILRDV EANTVRLKEH
260 270 280 290 300
DQDVLVLEKV PAGNRASNQG NSQPQQKYTV MSGTPEKILE HFLETIRLEA
310 320 330 340 350
TLNEATDSVL NDFIMMHCVF MPNTQLCPAL VAHYHAQPSQ GTEQEKMDYA
360 370 380 390 400
LNNKRRVIRL VLQWAAMYGD LLQEDDVSMA FLEEFYVSVS DDARMIAALK
410 420 430 440 450
EQLPELEKIV KQISEDAKAP QKKHKVLLQQ FNTGDERAQK RQPIRGSDEV
460 470 480 490 500
LFKVYCMDHT YTTIRVPVAT SVKEVISAVA DKLGSGEGLI IVKMSSGGEK
510 520 530 540 550
VVLKPNDVSV FTTLTINGRL FACPREQFDS LTPLPEQEGP TVGTVGTFEL
560 570 580 590 600
MSSKDLAYQM TIYDWELFNC VHELELIYHT FGRHNFKKTT ANLDLFLRRF
610 620 630 640 650
NEIQFWVVTE ICLCSQLSKR VQLLKKFIKI AAHCKEYKNL NSFFAIVMGL
660 670 680 690 700
SNVAVSRLAL TWEKLPSKFK KFYAEFESLM DPSRNHRAYR LTVAKLEPPL
710 720 730 740 750
IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK MRMIANTART VRYYRSQPFN
760 770 780 790
PDAAQANKNH QDVRSYVRQL NVIDNQRTLS QMSHRLEPRR P
Length:791
Mass (Da):90,975
Last modified:March 3, 2009 - v1
Checksum:iD78EE91921EF294C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009484 Genomic DNA No translation available.
AC018712 Genomic DNA No translation available.
AC019046 Genomic DNA No translation available.
AC104086 Genomic DNA No translation available.
AK294433 mRNA Translation: BAH11764.1
AK294914 mRNA Translation: BAH11923.1
RefSeqiNP_001269830.1, NM_001282901.1
UniGeneiHs.470646

Genome annotation databases

EnsembliENST00000535187; ENSP00000438011; ENSG00000091428
GeneIDi11069
UCSCiuc010zeh.3 human

Similar proteinsi

Entry informationi

Entry nameiB7Z278_HUMAN
AccessioniPrimary (citable) accession number: B7Z278
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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