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Protein
Submitted name:

cDNA FLJ51566, highly similar to Pyruvate dehydrogenase (lipoamide) kinase isozyme 1 (EC 2.7.11.2)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of acetyl-CoA biosynthetic process from pyruvate Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

PyruvateImported

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ51566, highly similar to Pyruvate dehydrogenase (lipoamide) kinase isozyme 1 (EC 2.7.11.2)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial pyruvate dehydrogenase complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiB7Z207.
ExpressionAtlasiB7Z207. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliB7Z207.
SMRiB7Z207. Positions 1-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000511.

Family and domain databases

Gene3Di1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_C.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamiPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGVIEYKE SFGVDPVTSQ NVQYFLDRFY MSRISIRMLL NQHSLLFGGK
60 70 80 90 100
GKGSPSHRKH IGSINPNCNV LEVIKDGYEN ARRLCDLYYI NSPELELEEL
110 120 130 140 150
NAKSPGQPIQ VVYVPSHLYH MVFELFKNAM RATMEHHANR GVYPPIQVHV
160 170 180 190 200
TLGNEDLTVK MSDRGGGVPL RKIDRLFNYM YSTAPRPRVE TSRAVPLAGF
210 220 230 240 250
GYGLPISRLY AQYFQGDLKL YSLEGYGTDA VIYIKALSTD SIERLPVYNK
260 270 280
AAWKHYNTNH EADDWCVPSR EPKDMTTFRS A
Length:281
Mass (Da):32,036
Last modified:March 3, 2009 - v1
Checksum:iD6AABC3D0CFA611F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294194 mRNA. Translation: BAH11693.1.
UniGeneiHs.470633.
Hs.733780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294194 mRNA. Translation: BAH11693.1.
UniGeneiHs.470633.
Hs.733780.

3D structure databases

ProteinModelPortaliB7Z207.
SMRiB7Z207. Positions 1-268.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiB7Z207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000511.

Miscellaneous databases

NextBioi35478873.

Gene expression databases

BgeeiB7Z207.
ExpressionAtlasiB7Z207. baseline and differential.

Family and domain databases

Gene3Di1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_C.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamiPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported.

Entry informationi

Entry nameiB7Z207_HUMAN
AccessioniPrimary (citable) accession number: B7Z207
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 1, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.