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Protein

RNA binding protein fox-1 homolog

Gene

RBFOX1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein that regulates alternative splicing events.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicingUniRule annotation

Keywords - Ligandi

RNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homologUniRule annotation
Gene namesi
Name:RBFOX1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18222. RBFOX1.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z1U7.

Expressioni

Gene expression databases

BgeeiENSG00000078328.

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei161 – 1611Interaction with RNAUniRule annotation
Sitei169 – 1691Interaction with RNAUniRule annotation
Sitei170 – 1701Interaction with RNAUniRule annotation
Sitei194 – 1941Interaction with RNAUniRule annotation
Sitei199 – 1991Interaction with RNAUniRule annotation
Sitei203 – 2031Interaction with RNAUniRule annotation
Sitei227 – 2271Interaction with RNAUniRule annotation
Sitei237 – 2371Interaction with RNAUniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000309117.

Structurei

3D structure databases

SMRiB7Z1U7. Positions 118-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 23677RRM (RNA recognition motif)InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOVERGENiHBG000044.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z1U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGQRTHAS GTYSFLDRTQ HSDIKADCNT CVEIEDRKVS RQQMNCEREQ
60 70 80 90 100
LRGNQEAAAA PDTMAQPYAS AQFAPPQNGI PAEYTAPHPH PAPEYTGQTT
110 120 130 140 150
VPEHTLNLYP PAQTHSEQSP ADTSAQTVSG TATQTDDAAP TDGQPQTQPS
160 170 180 190 200
ENTENKSQPK RLHVSNIPFR FRDPDLRQMF GQFGKILDVE IIFNERGSKG
210 220 230 240 250
FGFVTFENSA DADRAREKLH GTVVEGRKIE VNNATARVMT NKKTVNPYTN
260 270 280 290 300
GWKLNPVVGA VYSPEFYAGT VLLCQANQEG SSMYSAPSSL VYTSAMPGFP
310 320 330 340 350
YPAATAAAAY RGAHLRGRGR TVYNTFRAAA PPPPIPAYGG VVYQDGFYGA
360 370 380 390 400
DIYGGYAAYR YAQPTPATAA AYSDSYGRVY AADPYHHALA PAPTYGVGAM
410 420
PQGSSPSTDF RGAKLHTSRP LLSGS
Length:425
Mass (Da):45,950
Last modified:March 3, 2009 - v1
Checksum:iE03E6ABD235979C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006112 Genomic DNA. No translation available.
AC007012 Genomic DNA. No translation available.
AC007217 Genomic DNA. No translation available.
AC007223 Genomic DNA. No translation available.
AC009135 Genomic DNA. No translation available.
AC022206 Genomic DNA. No translation available.
AC023829 Genomic DNA. No translation available.
AC079410 Genomic DNA. No translation available.
AC125796 Genomic DNA. No translation available.
AC131390 Genomic DNA. No translation available.
AK293951 mRNA. Translation: BAH11633.1.
RefSeqiNP_001295046.1. NM_001308117.1.
UniGeneiHs.459842.

Genome annotation databases

EnsembliENST00000422070; ENSP00000391269; ENSG00000078328.
GeneIDi54715.
UCSCiuc010uxz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006112 Genomic DNA. No translation available.
AC007012 Genomic DNA. No translation available.
AC007217 Genomic DNA. No translation available.
AC007223 Genomic DNA. No translation available.
AC009135 Genomic DNA. No translation available.
AC022206 Genomic DNA. No translation available.
AC023829 Genomic DNA. No translation available.
AC079410 Genomic DNA. No translation available.
AC125796 Genomic DNA. No translation available.
AC131390 Genomic DNA. No translation available.
AK293951 mRNA. Translation: BAH11633.1.
RefSeqiNP_001295046.1. NM_001308117.1.
UniGeneiHs.459842.

3D structure databases

SMRiB7Z1U7. Positions 118-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309117.

Proteomic databases

PeptideAtlasiB7Z1U7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422070; ENSP00000391269; ENSG00000078328.
GeneIDi54715.
UCSCiuc010uxz.1. human.

Organism-specific databases

CTDi54715.
HGNCiHGNC:18222. RBFOX1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOVERGENiHBG000044.

Miscellaneous databases

ChiTaRSiRBFOX1. human.
GenomeRNAii54715.

Gene expression databases

BgeeiENSG00000078328.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z1U7_HUMAN
AccessioniPrimary (citable) accession number: B7Z1U7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.