ID   B7Z1S6_HUMAN            Unreviewed;       229 AA.
AC   B7Z1S6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Grainyhead like transcription factor 1 {ECO:0000313|Ensembl:ENSP00000420654.1};
DE   SubName: Full=cDNA FLJ51493, highly similar to Grainyhead-like protein 1 {ECO:0000313|EMBL:BAH11612.1};
GN   Name=GRHL1 {ECO:0000313|Ensembl:ENSP00000420654.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11612.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000420654.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|EMBL:BAH11612.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAH11612.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [4] {ECO:0000313|Ensembl:ENSP00000420654.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC010969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK293855; BAH11612.1; -; mRNA.
DR   ProteomicsDB; 6363; -.
DR   Ensembl; ENST00000464418.5; ENSP00000420654.1; ENSG00000134317.18.
DR   UCSC; uc061gpf.1; human.
DR   HGNC; HGNC:17923; GRHL1.
DR   VEuPathDB; HostDB:ENSG00000134317; -.
DR   GeneTree; ENSGT00940000157612; -.
DR   HOGENOM; CLU_1209465_0_0_1; -.
DR   ChiTaRS; GRHL1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000134317; Expressed in upper arm skin and 150 other cell types or tissues.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR040167; TF_CP2-like.
DR   PANTHER; PTHR11037:SF16; GRAINYHEAD-LIKE PROTEIN 1 HOMOLOG; 1.
DR   PANTHER; PTHR11037; TRANSCRIPTION FACTOR CP2; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:B7Z1S6,
KW   ECO:0007829|PeptideAtlas:B7Z1S6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          77..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   229 AA;  25588 MW;  5B16BAF99226CD19 CRC64;
     MRKWTKKGNC KRPVLVLQNE ALYPQRRSYT SEDEAWKSFL ENPLTAATKA MMSINGDEDS
     AAALGLLYDY YKVPRERRSS TAKPEVEHPE PDHSKRNSIP IVTEQPLISA GENRVQVLKN
     VPFNIVLPHG NQLGIDKRGH LTAPDTTVTV SIATMPTHSI KTETQPHGFA VGIPPAVYHP
     EPTERVVVFD RNLNTDQFSS GAQAPNAQRR TPDSTFSETF KEGVQEEQL
//