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B7Z1I0

- B7Z1I0_HUMAN

UniProt

B7Z1I0 - B7Z1I0_HUMAN

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Protein
Submitted name: Integrin-linked protein kinase
Gene
ILK
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: Ensembl
  3. signal transducer activity Source: Ensembl

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: Ensembl
  2. cell aging Source: Ensembl
  3. cell cycle arrest Source: Ensembl
  4. establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
  5. extracellular fibril organization Source: Ensembl
  6. integrin-mediated signaling pathway Source: UniProtKB-KW
  7. myelin assembly Source: Ensembl
  8. myelination in peripheral nervous system Source: Ensembl
  9. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  10. negative regulation of neuron apoptotic process Source: Ensembl
  11. negative regulation of protein kinase activity Source: Ensembl
  12. negative regulation of smooth muscle cell migration Source: Ensembl
  13. negative regulation of smooth muscle cell proliferation Source: Ensembl
  14. nerve development Source: Ensembl
  15. neuron projection morphogenesis Source: Ensembl
  16. peptidyl-serine phosphorylation Source: Ensembl
  17. positive regulation of BMP signaling pathway Source: Ensembl
  18. positive regulation of MAP kinase activity Source: Ensembl
  19. positive regulation of axon extension Source: Ensembl
  20. positive regulation of cell migration Source: Ensembl
  21. positive regulation of cell proliferation Source: Ensembl
  22. positive regulation of cell-matrix adhesion Source: Ensembl
  23. positive regulation of dendrite morphogenesis Source: Ensembl
  24. positive regulation of myoblast differentiation Source: Ensembl
  25. positive regulation of osteoblast differentiation Source: Ensembl
  26. positive regulation of protein kinase B signaling Source: Ensembl
  27. protein heterooligomerization Source: Ensembl
  28. protein kinase B signaling Source: Ensembl
  29. regulation of actin cytoskeleton organization Source: Ensembl
  30. substrate adhesion-dependent cell spreading Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

IntegrinImported, KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin-linked protein kinaseImported
Submitted name:
cDNA FLJ53825, highly similar to Integrin-linked protein kinase 1 (EC 2.7.11.1)Imported
Gene namesi
Name:ILKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6040. ILK.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: HPA
  2. cell-cell junction Source: Ensembl
  3. costamere Source: Ensembl
  4. cytoplasm Source: HPA
  5. dendritic shaft Source: Ensembl
  6. focal adhesion Source: HPA
  7. lamellipodium Source: Ensembl
  8. neuronal cell body Source: Ensembl
  9. nucleus Source: HPA
  10. protein complex Source: Ensembl
  11. terminal bouton Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliB7Z1I0.
SMRiB7Z1I0. Positions 1-37, 51-318.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG002437.
KOiK06272.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z1I0-1 [UniParc]FASTAAdd to Basket

« Hide

MPVDKAKAPL RELLRERAEK MGQNLNRIPY KDTFWKGTTR TRPRNGTLNK    50
HSGIDFKQLN FLTKLNENHS GELWKGRWQG NDIVVKVLKV RDWSTRKSRD 100
FNEECPRLRI FSHPNVLPVL GACQSPPAPH PTLITHWMPY GSLYNVLHEG 150
TNFVVDQSQA VKFALDMARG MAFLHTLEPL IPRHALNSRS VMIDEDMTAR 200
ISMADVKFSF QCPGRMYAPA WVAPEALQKK PEDTNRRSAD MWSFAVLLWE 250
LVTREVPFAD LSNMEIGMKV ALEGLRPTIP PGISPHVCKL MKICMNEDPA 300
KRPKFDMIVP ILEKMQDK 318
Length:318
Mass (Da):36,467
Last modified:March 3, 2009 - v1
Checksum:i7516E37CB8353644
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091564 Genomic DNA. No translation available.
AK293474 mRNA. Translation: BAH11516.1.
RefSeqiNP_001265371.1. NM_001278442.1.
XP_005252962.1. XM_005252905.1.
UniGeneiHs.706355.

Genome annotation databases

EnsembliENST00000537806; ENSP00000439606; ENSG00000166333.
GeneIDi3611.
KEGGihsa:3611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091564 Genomic DNA. No translation available.
AK293474 mRNA. Translation: BAH11516.1 .
RefSeqi NP_001265371.1. NM_001278442.1.
XP_005252962.1. XM_005252905.1.
UniGenei Hs.706355.

3D structure databases

ProteinModelPortali B7Z1I0.
SMRi B7Z1I0. Positions 1-37, 51-318.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000537806 ; ENSP00000439606 ; ENSG00000166333 .
GeneIDi 3611.
KEGGi hsa:3611.

Organism-specific databases

CTDi 3611.
HGNCi HGNC:6040. ILK.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG002437.
KOi K06272.

Miscellaneous databases

ChiTaRSi ILK. human.
GenomeRNAii 3611.
NextBioi 35478734.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: CerebellumImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7Z1I0_HUMAN
AccessioniPrimary (citable) accession number: B7Z1I0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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