B7Z1I0 (B7Z1I0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Integrin-linked protein kinase Ensembl ENSP00000439606

Submitted name:
cDNA FLJ53825, highly similar to Integrin-linked protein kinase 1 (EC 2.7.11.1) EMBL BAH11516.1

Gene names

Name:

ILK Ensembl ENSP00000439606

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAH11516.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Integrin EMBL BAH11516.1 Kinase EMBL BAH11516.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: Compara establishment or maintenance of epithelial cell apical/basal polarity Inferred from electronic annotation. Source: Compara extracellular fibril organization Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW myelin assembly Inferred from electronic annotation. Source: Compara negative regulation of cardiac muscle cell apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of protein kinase activity Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell migration Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara neuron projection morphogenesis Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of axon extension Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cell-matrix adhesion Inferred from electronic annotation. Source: Compara positive regulation of dendrite morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of myoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara protein heterooligomerization Inferred from electronic annotation. Source: Compara regulation of actin cytoskeleton organization Inferred from electronic annotation. Source: Compara substrate adhesion-dependent cell spreading Inferred from electronic annotation. Source: Compara
Cellular_component	cell-cell junction Inferred from electronic annotation. Source: Compara costamere Inferred from electronic annotation. Source: Compara dendritic shaft Inferred from electronic annotation. Source: Compara focal adhesion Inferred from electronic annotation. Source: Compara lamellipodium Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara signal transducer activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z1I0 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 7516E37CB8353644	FASTA	318	36,467
	10 20 30 40 50 60 MPVDKAKAPL RELLRERAEK MGQNLNRIPY KDTFWKGTTR TRPRNGTLNK HSGIDFKQLN 70 80 90 100 110 120 FLTKLNENHS GELWKGRWQG NDIVVKVLKV RDWSTRKSRD FNEECPRLRI FSHPNVLPVL 130 140 150 160 170 180 GACQSPPAPH PTLITHWMPY GSLYNVLHEG TNFVVDQSQA VKFALDMARG MAFLHTLEPL 190 200 210 220 230 240 IPRHALNSRS VMIDEDMTAR ISMADVKFSF QCPGRMYAPA WVAPEALQKK PEDTNRRSAD 250 260 270 280 290 300 MWSFAVLLWE LVTREVPFAD LSNMEIGMKV ALEGLRPTIP PGISPHVCKL MKICMNEDPA 310 KRPKFDMIVP ILEKMQDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Cerebellum EMBL BAH11516.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC091564 Genomic DNA. No translation available. AK293474 mRNA. Translation: BAH11516.1.
IPI	IPI01012931.
UniGene	Hs.706355.
3D structure databases
SMR	B7Z1I0. Positions 1-36, 51-318.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000537806; ENSP00000439606; ENSG00000166333.
Organism-specific databases
HGNC	HGNC:6040. ILK.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG002437.
Gene expression databases
ArrayExpress	B7Z1I0.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ILK. human.
NextBio	35478734.

Entry information

Entry name

B7Z1I0_HUMAN

Accession

Primary (citable) accession number: B7Z1I0

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.