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Protein
Submitted name:

cDNA FLJ53967, highly similar to Pro-neuregulin-1, membrane-bound isoform

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ53967, highly similar to Pro-neuregulin-1, membrane-bound isoformImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 108HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 67PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiB7Z1E3.
PaxDbiB7Z1E3.
PeptideAtlasiB7Z1E3.

Expressioni

Gene expression databases

BgeeiENSG00000157168.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349275.

Structurei

3D structure databases

ProteinModelPortaliB7Z1E3.
SMRiB7Z1E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 68EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
HOVERGENiHBG006531.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
PANTHERiPTHR11100:SF30. PTHR11100:SF30. 1 hit.
PfamiView protein in Pfam
PF02158. Neuregulin. 1 hit.
PRINTSiPR01089. NEUREGULIN.
SMARTiView protein in SMART
SM00181. EGF. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z1E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIPKHISIE DITATSTSTT GTSHLVKCAE KEKTFCVNGG ECFMVKDLSN
60 70 80 90 100
PSRYLCKCPN EFTGDRCQNY VMASFYKAEE LYQKRVLTIT GICIALLVVG
110 120 130 140 150
IMCVVAYCKT KKQRKKLHDR LRQSLRSERN NMMNIANGPH HPNPPPENVQ
160 170 180 190 200
LVNQYVSKNV ISSEHIVERE AETSFSTSHY TSTAHHSTTV TQTPSHSWSN
210 220 230 240 250
GHTESILSES HSVIVMSSVE NSRHSSPTGG PRGRLNGTGG PRECNSFLRH
260 270 280 290 300
ARETPDSYRD SPHSERYVSA MTTPARMSPV DFHTPSSPKS PPSEMSPPVS
310 320 330 340 350
SMTVSMPSMA VSPFMEEERP LLLVTPPRLR EKKFDHHPQQ FSSFHHNPAH
360 370 380 390 400
DSNSLPASPL RIVEDEEYET TQEYEPAQEP VKKLANSRRA KRTKPNGHIA
410 420 430 440 450
NRLEVDSNTS SQSSNSESET EDERVGEDTP FLGIQNPLAA SLEATPAFRL
460 470 480
ADSRTNPAGR FSTQEEIQAR LSSVIANQDP IAV
Length:483
Mass (Da):53,725
Last modified:March 3, 2009 - v1
Checksum:i39B94B909F1D3DE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293270 mRNA. Translation: BAH11479.1.
RefSeqiNP_001309126.1. NM_001322197.1.
UniGeneiHs.453951.
Hs.668810.

Genome annotation databases

GeneIDi3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293270 mRNA. Translation: BAH11479.1.
RefSeqiNP_001309126.1. NM_001322197.1.
UniGeneiHs.453951.
Hs.668810.

3D structure databases

ProteinModelPortaliB7Z1E3.
SMRiB7Z1E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349275.

Proteomic databases

MaxQBiB7Z1E3.
PaxDbiB7Z1E3.
PeptideAtlasiB7Z1E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3084.

Organism-specific databases

CTDi3084.

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
HOVERGENiHBG006531.

Miscellaneous databases

ChiTaRSiNRG1. human.

Gene expression databases

BgeeiENSG00000157168.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
PANTHERiPTHR11100:SF30. PTHR11100:SF30. 1 hit.
PfamiView protein in Pfam
PF02158. Neuregulin. 1 hit.
PRINTSiPR01089. NEUREGULIN.
SMARTiView protein in SMART
SM00181. EGF. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z1E3_HUMAN
AccessioniPrimary (citable) accession number: B7Z1E3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 7, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.