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Protein
Submitted name:

cDNA FLJ53967, highly similar to Pro-neuregulin-1, membrane-bound isoform

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ53967, highly similar to Pro-neuregulin-1, membrane-bound isoformImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 108HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 67PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiB7Z1E3
PeptideAtlasiB7Z1E3
PRIDEiB7Z1E3

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB7Z1E3
SMRiB7Z1E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 68EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9 Eukaryota
ENOG4110ST7 LUCA
HOVERGENiHBG006531

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002154 Neuregulin_C
IPR018250 NRG1
PANTHERiPTHR11100:SF7 PTHR11100:SF7, 1 hit
PfamiView protein in Pfam
PF02158 Neuregulin, 1 hit
PRINTSiPR01089 NEUREGULIN
SMARTiView protein in SMART
SM00181 EGF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z1E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIPKHISIE DITATSTSTT GTSHLVKCAE KEKTFCVNGG ECFMVKDLSN
60 70 80 90 100
PSRYLCKCPN EFTGDRCQNY VMASFYKAEE LYQKRVLTIT GICIALLVVG
110 120 130 140 150
IMCVVAYCKT KKQRKKLHDR LRQSLRSERN NMMNIANGPH HPNPPPENVQ
160 170 180 190 200
LVNQYVSKNV ISSEHIVERE AETSFSTSHY TSTAHHSTTV TQTPSHSWSN
210 220 230 240 250
GHTESILSES HSVIVMSSVE NSRHSSPTGG PRGRLNGTGG PRECNSFLRH
260 270 280 290 300
ARETPDSYRD SPHSERYVSA MTTPARMSPV DFHTPSSPKS PPSEMSPPVS
310 320 330 340 350
SMTVSMPSMA VSPFMEEERP LLLVTPPRLR EKKFDHHPQQ FSSFHHNPAH
360 370 380 390 400
DSNSLPASPL RIVEDEEYET TQEYEPAQEP VKKLANSRRA KRTKPNGHIA
410 420 430 440 450
NRLEVDSNTS SQSSNSESET EDERVGEDTP FLGIQNPLAA SLEATPAFRL
460 470 480
ADSRTNPAGR FSTQEEIQAR LSSVIANQDP IAV
Length:483
Mass (Da):53,725
Last modified:March 3, 2009 - v1
Checksum:i39B94B909F1D3DE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293270 mRNA Translation: BAH11479.1
RefSeqiNP_001309126.1, NM_001322197.1
UniGeneiHs.453951
Hs.668810

Genome annotation databases

GeneIDi3084

Similar proteinsi

Entry informationi

Entry nameiB7Z1E3_HUMAN
AccessioniPrimary (citable) accession number: B7Z1E3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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