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Protein

Protein kinase C

Gene

Pkcdelta

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei372ATPUniRule annotation1
Active sitei467Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 357ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLinkiB7Z147

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotationSAAS annotation (EC:2.7.11.13UniRule annotationSAAS annotation)
Gene namesi
Name:PkcdeltaImported
Synonyms:CG10524Imported, CG11245Imported, Dmel\CG42349Imported, PKCdImported, PKCdeltaImported
ORF Names:CG42349Imported, Dmel_CG42349Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0259680 Pkcdelta

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiB7Z147

Expressioni

Gene expression databases

BgeeiFBgn0259680
ExpressionAtlasiB7Z147 baseline and differential
GenevisibleiB7Z147 DM

Structurei

3D structure databases

ProteinModelPortaliB7Z147
SMRiB7Z147
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 194Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini216 – 266Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini343 – 601Protein kinaseInterPro annotationAdd BLAST259
Domaini602 – 671AGC-kinase C-terminalInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
KOiK06068
OrthoDBiEOG091G0QRS
PhylomeDBiB7Z147

Family and domain databases

CDDicd00029 C1, 2 hits
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR017892 Pkinase_C
IPR014376 Prot_kin_PKC_delta
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000551 PKC_delta, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

B7Z147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFTRAQVRK QKTSNSSSQR PRSSGGSTRH ETRYKQSSTS SSGAGSGLSG
60 70 80 90 100
ASGASGARRD QYRDRDHYGK HSFELPRQHS KEEAYHRDRE SSAGGVDRGE
110 120 130 140 150
RSGIGGNGGG VTGGGVYVDR RTRPRSITNR RGAIKHQKTH DINGHRFVAK
160 170 180 190 200
FFRQPTFCAF CNLFLWGFGK QGYQCIICQT VVHKKCHDKL LGKCSGSVFT
210 220 230 240 250
SASTILLRER FKIDMPHRFK PHTFMSPTFC DHCGSLMGGF FIQGLKCEEC
260 270 280 290 300
DVNCHKKCER LTANLCGVNQ KLIVEALNHV KRGAREARDS PSTPPSLNPA
310 320 330 340 350
YKIEASEEHD ETSYTYSQFQ KSGRFTAPAT VIPRFKNYSV DDFHFLAVLG
360 370 380 390 400
KGSFGKVLLA ELRDTTYYYA IKCLKKDVVL EDDDVDSTLI ERKVLALGTK
410 420 430 440 450
HPYLCHLFCT FQTESHLFFV MEYLNGGDLM FHIQESGRFS EERARFYGAE
460 470 480 490 500
IISGLKFLHK KGIIYRDLKL DNVLLDYEGH VRIADFGMCK LQIYLDKTAD
510 520 530 540 550
SFCGTPDYMA PEIIKGEKYN QNVDWWSFGV LLYEMLIGQS PFSGCDEDEL
560 570 580 590 600
FWSICNEIPW FPVYISAEAT GILKGLLEKD YTKRIGSQYS PAGDIADHIF
610 620 630 640 650
FRPIDWGLLE KRQIEPPFKP QVKHPLDTQY FDRVFTRERV RLTPIDKEIL
660 670
ASMDQKQFHG FTYTNPHITL D
Length:671
Mass (Da):76,333
Last modified:March 3, 2009 - v1
Checksum:i552783774078196C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ACL82923.1
RefSeqiNP_001138191.1, NM_001144719.2
NP_511171.3, NM_078616.4
UniGeneiDm.23809

Genome annotation databases

EnsemblMetazoaiFBtr0299936; FBpp0289213; FBgn0259680
FBtr0299937; FBpp0289214; FBgn0259680
GeneIDi32191
KEGGidme:Dmel_CG42349

Similar proteinsi

Entry informationi

Entry nameiB7Z147_DROME
AccessioniPrimary (citable) accession number: B7Z147
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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