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Protein

Protein kinase C

Gene

Pkcdelta

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLinkiB7Z147.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotationSAAS annotation (EC:2.7.11.13UniRule annotationSAAS annotation)
Gene namesi
Name:PkcdeltaImported
ORF Names:CG42349Imported, Dmel_CG42349Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0259680. Pkcdelta.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiB7Z147.
PRIDEiB7Z147.

Expressioni

Gene expression databases

BgeeiFBgn0259680.
ExpressionAtlasiB7Z147. differential.
GenevisibleiB7Z147. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0289212.

Structurei

3D structure databases

ProteinModelPortaliB7Z147.
SMRiB7Z147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 194Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini216 – 266Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini343 – 601Protein kinaseInterPro annotationAdd BLAST259
Domaini602 – 671AGC-kinase C-terminalInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
KOiK06068.
OrthoDBiEOG091G0QRS.
PhylomeDBiB7Z147.

Family and domain databases

CDDicd00029. C1. 2 hits.
InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiView protein in SMART
SM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

B7Z147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFTRAQVRK QKTSNSSSQR PRSSGGSTRH ETRYKQSSTS SSGAGSGLSG
60 70 80 90 100
ASGASGARRD QYRDRDHYGK HSFELPRQHS KEEAYHRDRE SSAGGVDRGE
110 120 130 140 150
RSGIGGNGGG VTGGGVYVDR RTRPRSITNR RGAIKHQKTH DINGHRFVAK
160 170 180 190 200
FFRQPTFCAF CNLFLWGFGK QGYQCIICQT VVHKKCHDKL LGKCSGSVFT
210 220 230 240 250
SASTILLRER FKIDMPHRFK PHTFMSPTFC DHCGSLMGGF FIQGLKCEEC
260 270 280 290 300
DVNCHKKCER LTANLCGVNQ KLIVEALNHV KRGAREARDS PSTPPSLNPA
310 320 330 340 350
YKIEASEEHD ETSYTYSQFQ KSGRFTAPAT VIPRFKNYSV DDFHFLAVLG
360 370 380 390 400
KGSFGKVLLA ELRDTTYYYA IKCLKKDVVL EDDDVDSTLI ERKVLALGTK
410 420 430 440 450
HPYLCHLFCT FQTESHLFFV MEYLNGGDLM FHIQESGRFS EERARFYGAE
460 470 480 490 500
IISGLKFLHK KGIIYRDLKL DNVLLDYEGH VRIADFGMCK LQIYLDKTAD
510 520 530 540 550
SFCGTPDYMA PEIIKGEKYN QNVDWWSFGV LLYEMLIGQS PFSGCDEDEL
560 570 580 590 600
FWSICNEIPW FPVYISAEAT GILKGLLEKD YTKRIGSQYS PAGDIADHIF
610 620 630 640 650
FRPIDWGLLE KRQIEPPFKP QVKHPLDTQY FDRVFTRERV RLTPIDKEIL
660 670
ASMDQKQFHG FTYTNPHITL D
Length:671
Mass (Da):76,333
Last modified:March 3, 2009 - v1
Checksum:i552783774078196C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: ACL82923.1.
RefSeqiNP_001138191.1. NM_001144719.2.
NP_511171.3. NM_078616.4.
UniGeneiDm.23809.

Genome annotation databases

EnsemblMetazoaiFBtr0299936; FBpp0289213; FBgn0259680.
FBtr0299937; FBpp0289214; FBgn0259680.
GeneIDi32191.
KEGGidme:Dmel_CG42349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: ACL82923.1.
RefSeqiNP_001138191.1. NM_001144719.2.
NP_511171.3. NM_078616.4.
UniGeneiDm.23809.

3D structure databases

ProteinModelPortaliB7Z147.
SMRiB7Z147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0289212.

Proteomic databases

PaxDbiB7Z147.
PRIDEiB7Z147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0299936; FBpp0289213; FBgn0259680.
FBtr0299937; FBpp0289214; FBgn0259680.
GeneIDi32191.
KEGGidme:Dmel_CG42349.

Organism-specific databases

CTDi32191.
FlyBaseiFBgn0259680. Pkcdelta.

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
KOiK06068.
OrthoDBiEOG091G0QRS.
PhylomeDBiB7Z147.

Enzyme and pathway databases

SignaLinkiB7Z147.

Miscellaneous databases

ChiTaRSiPkcdelta. fly.
GenomeRNAii32191.

Gene expression databases

BgeeiFBgn0259680.
ExpressionAtlasiB7Z147. differential.
GenevisibleiB7Z147. DM.

Family and domain databases

CDDicd00029. C1. 2 hits.
InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiView protein in SMART
SM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z147_DROME
AccessioniPrimary (citable) accession number: B7Z147
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 18, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.