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Protein
Submitted name:

Bestrophin 1, isoform B

Gene

Best1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chloride channel activity Source: FlyBase
  • intracellular calcium activated chloride channel activity Source: FlyBase
  • volume-sensitive chloride channel activity Source: FlyBase

GO - Biological processi

  • cellular water homeostasis Source: FlyBase
  • cell volume homeostasis Source: FlyBase
  • chloride transport Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-2672351 Stimuli-sensing channels

Protein family/group databases

TCDBi1.A.46.1.5 the anion channel-forming bestrophin (bestrophin) family

Names & Taxonomyi

Protein namesi
Submitted name:
Bestrophin 1, isoform BImported
Gene namesi
Name:Best1Imported
Synonyms:anon-WO0118547.380Imported, bestImported, DbestImported, dBest1Imported, dbest1Imported, dmBest1Imported, Dmel\CG6264Imported
ORF Names:CG6264Imported, Dmel_CG6264Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0040238 Best1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 47HelicalSequence analysisAdd BLAST19
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Transmembranei129 – 146HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiB7Z0U6

Expressioni

Gene expression databases

BgeeiFBgn0040238
ExpressionAtlasiB7Z0U6 baseline and differential
GenevisibleiB7Z0U6 DM

Interactioni

Protein-protein interaction databases

IntActiB7Z0U6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliB7Z0U6
SMRiB7Z0U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili690 – 710Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3547 Eukaryota
ENOG410XS3J LUCA
GeneTreeiENSGT00390000002997
InParanoidiB7Z0U6
KOiK22204
OrthoDBiEOG091G06XO
PhylomeDBiB7Z0U6

Family and domain databases

InterProiView protein in InterPro
IPR000615 Bestrophin
IPR021134 Bestrophin/UPF0187
PANTHERiPTHR10736 PTHR10736, 1 hit
PfamiView protein in Pfam
PF01062 Bestrophin, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z0U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITYTGEVA TCRGFGCFLK LLLRWRGSIY KLVWLDLLAF LTIYYAINMV
60 70 80 90 100
YRFGLNPAQK ETFEAIVQYC DSYRELIPLS FVLGFYVSIV MTRWWNQYTS
110 120 130 140 150
IPWPDPIAVF VSSNVHGQDE RGRMMRRTIM RYVCLCLTMV LANVSPRVKK
160 170 180 190 200
RFPGLNNLVE AGLLNDNEKT IIETMNKAFP RPSKHWLPIV WAASIITRAR
210 220 230 240 250
KEGRIRDDFA VKTIIDELNK FRGQCGLLIS YDTISVPLVY TQVVTLAVYS
260 270 280 290 300
YFLTCCMGQQ WTDGKVVGNT TYLNKVDLYF PVFTTLQFFF YMGWLKVAES
310 320 330 340 350
LINPFGEDDD DFEVNWMVDR NLQVSYLIVD EMHHDHPELL KDQYWDEVFP
360 370 380 390 400
NELPYTIAAE RFRENHPEPS TAKIEVPKNA AMPSTMSSVR IDEMVGNANG
410 420 430 440 450
DPAAAADAKA PNPVTGQVQV PGADTGVQTV TYDFPKGSPD EEADDASGIH
460 470 480 490 500
FSAGNGKMRL DSSPSLVSVS GTLSRVNTVA SALKRFLSRD DSRPGSATPS
510 520 530 540 550
QDQPYKFPAS ASSASLSGAV VGSATSAGKP AGSLRITQQV IEEVDEQATI
560 570 580 590 600
TSMRANDPRP NVMDIFAQTS SGAGTSGPLQ PPPAHSEPVD IPSRPPSYNR
610 620 630 640 650
AQSQYEPNLF PPGGVDALLS TSAPAGGSPL LLSNAATAPS SPVGESSKSL
660 670 680 690 700
YDPQKGASRE TVESMDLRSS TDLLGDAAVQ PEDEGDDFDK LKAEREKEKL
710 720 730 740 750
MRQQKNLART ISTAPGMEAT AVPMVPMVPV NVAVQQAQLQ PVASSADLLA
760
GGDQFSNSTM KSEDAINGS
Length:769
Mass (Da):84,350
Last modified:March 3, 2009 - v1
Checksum:i441B7A2110625441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: ACL83492.1
RefSeqiNP_001138033.1, NM_001144561.2
UniGeneiDm.3335

Genome annotation databases

EnsemblMetazoaiFBtr0114590; FBpp0113082; FBgn0040238
GeneIDi53431
KEGGidme:Dmel_CG6264

Entry informationi

Entry nameiB7Z0U6_DROME
AccessioniPrimary (citable) accession number: B7Z0U6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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