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Protein
Submitted name:

Bestrophin 1, isoform B

Gene

Best1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chloride channel activity Source: FlyBase
  • intracellular calcium activated chloride channel activity Source: FlyBase
  • volume-sensitive chloride channel activity Source: FlyBase

GO - Biological processi

  • cellular water homeostasis Source: FlyBase
  • cell volume homeostasis Source: FlyBase
  • chloride transmembrane transport Source: GOC
  • chloride transport Source: FlyBase
  • regulation of anion transport Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-2672351. Stimuli-sensing channels.

Protein family/group databases

TCDBi1.A.46.1.5. the anion channel-forming bestrophin (bestrophin) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Bestrophin 1, isoform BImported
Gene namesi
Name:Best1Imported
ORF Names:CG6264Imported, Dmel_CG6264Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0040238. Best1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4719HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9520HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14618HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiB7Z0U6.

Expressioni

Gene expression databases

BgeeiB7Z0U6.
GenevisibleiB7Z0U6. DM.

Interactioni

Protein-protein interaction databases

IntActiB7Z0U6. 1 interaction.
STRINGi7227.FBpp0297165.

Structurei

3D structure databases

ProteinModelPortaliB7Z0U6.
SMRiB7Z0U6. Positions 2-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3547. Eukaryota.
ENOG410XS3J. LUCA.
GeneTreeiENSGT00390000002997.
InParanoidiB7Z0U6.
OrthoDBiEOG7N0C43.
PhylomeDBiB7Z0U6.

Family and domain databases

InterProiIPR000615. Bestrophin.
IPR021134. Bestrophin/UPF0187.
[Graphical view]
PANTHERiPTHR10736. PTHR10736. 1 hit.
PfamiPF01062. Bestrophin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z0U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITYTGEVA TCRGFGCFLK LLLRWRGSIY KLVWLDLLAF LTIYYAINMV
60 70 80 90 100
YRFGLNPAQK ETFEAIVQYC DSYRELIPLS FVLGFYVSIV MTRWWNQYTS
110 120 130 140 150
IPWPDPIAVF VSSNVHGQDE RGRMMRRTIM RYVCLCLTMV LANVSPRVKK
160 170 180 190 200
RFPGLNNLVE AGLLNDNEKT IIETMNKAFP RPSKHWLPIV WAASIITRAR
210 220 230 240 250
KEGRIRDDFA VKTIIDELNK FRGQCGLLIS YDTISVPLVY TQVVTLAVYS
260 270 280 290 300
YFLTCCMGQQ WTDGKVVGNT TYLNKVDLYF PVFTTLQFFF YMGWLKVAES
310 320 330 340 350
LINPFGEDDD DFEVNWMVDR NLQVSYLIVD EMHHDHPELL KDQYWDEVFP
360 370 380 390 400
NELPYTIAAE RFRENHPEPS TAKIEVPKNA AMPSTMSSVR IDEMVGNANG
410 420 430 440 450
DPAAAADAKA PNPVTGQVQV PGADTGVQTV TYDFPKGSPD EEADDASGIH
460 470 480 490 500
FSAGNGKMRL DSSPSLVSVS GTLSRVNTVA SALKRFLSRD DSRPGSATPS
510 520 530 540 550
QDQPYKFPAS ASSASLSGAV VGSATSAGKP AGSLRITQQV IEEVDEQATI
560 570 580 590 600
TSMRANDPRP NVMDIFAQTS SGAGTSGPLQ PPPAHSEPVD IPSRPPSYNR
610 620 630 640 650
AQSQYEPNLF PPGGVDALLS TSAPAGGSPL LLSNAATAPS SPVGESSKSL
660 670 680 690 700
YDPQKGASRE TVESMDLRSS TDLLGDAAVQ PEDEGDDFDK LKAEREKEKL
710 720 730 740 750
MRQQKNLART ISTAPGMEAT AVPMVPMVPV NVAVQQAQLQ PVASSADLLA
760
GGDQFSNSTM KSEDAINGS
Length:769
Mass (Da):84,350
Last modified:March 3, 2009 - v1
Checksum:i441B7A2110625441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: ACL83492.1.
RefSeqiNP_001138033.1. NM_001144561.2.
UniGeneiDm.3335.

Genome annotation databases

EnsemblMetazoaiFBtr0114590; FBpp0113082; FBgn0040238.
GeneIDi53431.
KEGGidme:Dmel_CG6264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: ACL83492.1.
RefSeqiNP_001138033.1. NM_001144561.2.
UniGeneiDm.3335.

3D structure databases

ProteinModelPortaliB7Z0U6.
SMRiB7Z0U6. Positions 2-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7Z0U6. 1 interaction.
STRINGi7227.FBpp0297165.

Protein family/group databases

TCDBi1.A.46.1.5. the anion channel-forming bestrophin (bestrophin) family.

Proteomic databases

PaxDbiB7Z0U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0114590; FBpp0113082; FBgn0040238.
GeneIDi53431.
KEGGidme:Dmel_CG6264.

Organism-specific databases

CTDi7439.
FlyBaseiFBgn0040238. Best1.

Phylogenomic databases

eggNOGiKOG3547. Eukaryota.
ENOG410XS3J. LUCA.
GeneTreeiENSGT00390000002997.
InParanoidiB7Z0U6.
OrthoDBiEOG7N0C43.
PhylomeDBiB7Z0U6.

Enzyme and pathway databases

ReactomeiR-DME-2672351. Stimuli-sensing channels.

Miscellaneous databases

GenomeRNAii53431.

Gene expression databases

BgeeiB7Z0U6.
GenevisibleiB7Z0U6. DM.

Family and domain databases

InterProiIPR000615. Bestrophin.
IPR021134. Bestrophin/UPF0187.
[Graphical view]
PANTHERiPTHR10736. PTHR10736. 1 hit.
PfamiPF01062. Bestrophin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.

Entry informationi

Entry nameiB7Z0U6_DROME
AccessioniPrimary (citable) accession number: B7Z0U6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.