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Protein
Submitted name:

Nedd4, isoform H

Gene

Nedd4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

TransferaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Enzyme and pathway databases

SignaLinkiB7Z068.

Names & Taxonomyi

Protein namesi
Submitted name:
Nedd4, isoform HImported
Gene namesi
Name:Nedd4Imported
ORF Names:CG42279Imported, Dmel_CG42279Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0259174. Nedd4.

PTM / Processingi

Proteomic databases

PaxDbiB7Z068.

Expressioni

Gene expression databases

BgeeiFBgn0259174.
ExpressionAtlasiB7Z068. baseline.
GenevisibleiB7Z068. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0289746.

Structurei

3D structure databases

ProteinModelPortaliB7Z068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 159C2InterPro annotationAdd BLAST88
Domaini246 – 279WWInterPro annotationAdd BLAST34
Domaini516 – 549WWInterPro annotationAdd BLAST34
Domaini567 – 600WWInterPro annotationAdd BLAST34
Domaini659 – 993HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd BLAST335

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.
OrthoDBiEOG091G0SS8.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 3 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 3 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 3 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 3 hits.
PS50020. WW_DOMAIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARSSGLVA AAALPVPSSS SSVAGGDVPR PPPRRRAASV AGQQQTRQEF
60 70 80 90 100
GNGYTPRRSL AAVNDSGDSC HLRIVVLTGQ SLAKKDIFGA SDPYVRIDLN
110 120 130 140 150
TINGDINIDS VLTKTKKKTL NPTWNEEFIF RVKPSEHKLV FQVFDENRLT
160 170 180 190 200
RDDFLGMVEL TLVNLPTEQE GRTIGEQSYT LRPRRSVGAK SRIKGTLRIY
210 220 230 240 250
HAFIRETREQ SEPSSGNSDG EWEHVEATNA GETSAQPHPF PTGGHDALPA
260 270 280 290 300
GWEERQDANG RTYYVNHTAR TTQWDRPTVL NSHSSQSTDD QLASDFQRRF
310 320 330 340 350
HISVDDTESG RSADSISHNS IEDNNNAAGL AYTPKTAATS SAPPNTPTNN
360 370 380 390 400
NGILAQIAMQ YRAEEDQDPT VDHTRQPEIS ATSLQNDLRP VREAPGVPDI
410 420 430 440 450
AITNPFTRRA AGNMAGGAGW QQERRRQQMQ LHIQQHQQRQ QQQQQNRILL
460 470 480 490 500
DVDHRQQEPQ HRGQRHQQQH RPSNEDTDHT DSHNPSDISA PSTRRNSEED
510 520 530 540 550
NAAVPPMEQN TGGEEEPLPP RWSMQVAPNG RTFFIDHASR RTTWIDPRNG
560 570 580 590 600
RASPMPNQTR RVEDDLGPLP EGWEERVHTD GRVFYIDHNT RTTQWEDPRL
610 620 630 640 650
SNPNIAGQAV PYSRDYKQKY EYFKSHIRKP TNVPNKFEIR IRRTSILEDS
660 670 680 690 700
YRIISSVTKT DLLKTKLWVE FEGETGLDYG GLAREWFYLL SKEMFNPYYG
710 720 730 740 750
LFEYSAMDNY TLQINNGSGL CNEEHLSYFK FIGRIAGMAV YHGKLLDAFF
760 770 780 790 800
IRPFYKMMLQ KPIDLKDMES VDTEYYNSLM WIKENDPRIL ELTFCLDEDV
810 820 830 840 850
FGQKSQHELK PGGANIDVTN ENKDEYIKLV IEWRFVARVK EQMSSFLDGF
860 870 880 890 900
GSIIPLNLIK IFDEHELELL MCGIQNIDVK DWRENTLYKG DYHMNHIIIQ
910 920 930 940 950
WFWRAVLSFS NEMRSRLLQF VTGTSRVPMN GFKELYGSNG PQMFTIEKWG
960 970 980 990
TPNNFPRAHT CFNRLDLPPY EGYLQLKDKL IKAIEGSQGF AGVD
Length:994
Mass (Da):113,366
Last modified:March 3, 2009 - v1
Checksum:iBD06A165F2FD8EA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: ACL83320.1.
RefSeqiNP_001137965.1. NM_001144493.3.
UniGeneiDm.988.

Genome annotation databases

EnsemblMetazoaiFBtr0299648; FBpp0288923; FBgn0259174.
GeneIDi39958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: ACL83320.1.
RefSeqiNP_001137965.1. NM_001144493.3.
UniGeneiDm.988.

3D structure databases

ProteinModelPortaliB7Z068.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0289746.

Proteomic databases

PaxDbiB7Z068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0299648; FBpp0288923; FBgn0259174.
GeneIDi39958.

Organism-specific databases

CTDi4734.
FlyBaseiFBgn0259174. Nedd4.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.
OrthoDBiEOG091G0SS8.

Enzyme and pathway databases

SignaLinkiB7Z068.

Miscellaneous databases

ChiTaRSiNedd4. fly.
GenomeRNAii39958.

Gene expression databases

BgeeiFBgn0259174.
ExpressionAtlasiB7Z068. baseline.
GenevisibleiB7Z068. DM.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 3 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 3 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 3 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 3 hits.
PS50020. WW_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z068_DROME
AccessioniPrimary (citable) accession number: B7Z068
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.