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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia garinii PBr
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei620ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:BGAPBR_0257Imported
OrganismiBorrelia garinii PBrImported
Taxonomic identifieri498743 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000006103 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 177tRNA-synt_1gInterPro annotationAdd BLAST135
Domaini227 – 410tRNA-synt_1_2InterPro annotationAdd BLAST184
Domaini423 – 581tRNA-synt_1InterPro annotationAdd BLAST159
Domaini617 – 643tRNA-synt_1InterPro annotationAdd BLAST27
Domaini686 – 802Anticodon_1InterPro annotationAdd BLAST117

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi617 – 621"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

B7XSS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKYEFIKIE KKWQEFWDNN KTYKVKEDPN IPKEKRLYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDIFGRYKL LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP
110 120 130 140 150
QKSTEENINK FKKQIKALGF AYDWDREIRT HDENYYKWTQ WIFLELYKKG
160 170 180 190 200
LAYAKEMPVW YCPELGTVLA NEEIIQTPDG PKSERGFHNV EKKYLRQWVL
210 220 230 240 250
KITKYAERLL NDLEELEWPE SVKEMQRNWI GKSTGVEIDF EIEGHNDKIT
260 270 280 290 300
VFTTRPDTIF GITYLVIAPE NKLIEKITKN NFKRNVLKYV KREELKSDLK
310 320 330 340 350
RTSLEKDKSG VFTGSYAFHP ITNEKIPIWV GSYVLGTYGS GAVMGVPAHD
360 370 380 390 400
ERDFQFAKKY KLKILPVISK SGKNEILEKA FIDDGISINS PNEFNNLKNS
410 420 430 440 450
EVKDKVIKWL IKNKKGKEKI TYKLRDWIFS RQRYWGEPIP ILFDKLGNAI
460 470 480 490 500
PLEKNDLPLK LPETANYKPS RTGESPLSRI KDWANLKDTG FTRETNTMPQ
510 520 530 540 550
WAGSCWYYLR YLDPKNPKEF ASKKKIEYWM PVDLYIGGAE HTVLHLLYSR
560 570 580 590 600
FWHKVLYDLG YVNTKEPFKK LINQGIITAF SYQKENGILI PNDQVIEKDN
610 620 630 640 650
KFFDKRDNKE VTQVIAKMSK SLKNVINPDD IIKEFGADSI RIYEMFMGPL
660 670 680 690 700
TDSKPWNTKG IIGVFRFLNK IWNLREKELS KDNPPKEIIS QLHKAIKKVT
710 720 730 740 750
EDTEKLNFNT AISAMMIFVN ELLKYEKNYL NIFKPFIIIL SPYAPHLAEE
760 770 780 790 800
LWEYIGETPS LFKNSKWPKF DENLIIKDAK EIVLQINGKI KDKILLSKET
810 820 830 840
DEEELKEIAM GNSKIKANLL NKKIVKIIAI KNKLVNIVIK
Length:840
Mass (Da):98,197
Last modified:March 3, 2009 - v1
Checksum:i686944538230D3DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABJV02000002 Genomic DNA. Translation: EED28961.1.
RefSeqiWP_004791606.1. NZ_ABJV02000002.1.

Genome annotation databases

EnsemblBacteriaiEED28961; EED28961; BGAPBR_0257.

Similar proteinsi

Entry informationi

Entry nameiB7XSS4_BORGR
AccessioniPrimary (citable) accession number: B7XSS4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported