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B7XK16

- SYIC_ENTBH

UniProt

B7XK16 - SYIC_ENTBH

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Protein

Probable isoleucine--tRNA ligase, cytoplasmic

Gene

EBI_22873

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
ORF Names:EBI_22873
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
ProteomesiUP000001742: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_22873.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Probable isoleucine--tRNA ligase, cytoplasmicPRO_0000388379Add
BLAST

Proteomic databases

PRIDEiB7XK16.

Structurei

3D structure databases

ProteinModelPortaliB7XK16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" regionBy similarityAdd
BLAST
Motifi634 – 6385"KMSKS" regionBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiB7XK16.
OrthoDBiEOG7FNCGS.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7XK16 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDKIIDFSK IEKDILKFWT ENKIFELCNK LSQGREEYVF FDGPPFATGL
60 70 80 90 100
PHYGHILSGT IKDIIGRFYY QKGFHVERRF GWDCHGLPVE YEIDKKFNIT
110 120 130 140 150
DRNQILKMGI DVYNHECRKI VQKYTNEWEE TVIRMGRWVD FKGSYKTMDL
160 170 180 190 200
EFMESIWFIF KELFKRNKIY RGFKIMPFST ACKTALSNFE ASQNYKNVSD
210 220 230 240 250
PSVLVTFKII NPKDVLHNYE NNDIEIFFVA WTTTPWTLPA NCALVINPDY
260 270 280 290 300
EYAIFYINNN SKKLYIMLKN RIEVYFKQFC ITTVILGKEL IGVSYATLFN
310 320 330 340 350
YYENYITRGF FKTIGGNFVT ITDGSGIVHT APAFGEEDYN IFLKLGLLKP
360 370 380 390 400
DEIPPCHIDE NGKFTIAMEK YVNVPINNDI SLNGVYFKDA DKIILQILKP
410 420 430 440 450
HLIYNSRIVH SYPFCWRSDT PLLYKLIPNW FVKITDIREE LLTQNKKINW
460 470 480 490 500
IPETIKYKRF QNWLSNAKDW AISRNRFWGT PLPIWARYEN EIYNYTDLIC
510 520 530 540 550
VGSIKELEDL TNTKITDLHR EHIDQLLIEH NGKTYKRIED VLDCWFESGS
560 570 580 590 600
MPYAQNHLKG IKVNNSLIDK LDNINLNNAY LIKENFPADF IGEGLDQTRG
610 620 630 640 650
WFYTLHVIST ILFNSPAFKN VIVNGIVLAE DGKKMSKRLK NYPDPMNIFN
660 670 680 690 700
KYGADALRMY LISSPVVEAE NLRFNENGVK EILKTLLIPW YNTLVFYKEC
710 720 730 740 750
QIQNHNHTLL LDAWIESELN ILINKVNIDM SEYKLNNILN YALDFIENLN
760 770 780 790 800
NWYIRINRKE LKNNGLYLKT IIKRFSIVMS AFVPFFSDYS YQIVCSDKIS
810 820 830 840 850
VHLEMIPEYK SINSDFNFIK CIIDGIRHLR EKYKLKLKKT LKEVIIVLDN
860 870 880 890 900
ININKNLFEK YEAVIKSECN TLDIILNDIN DYSISTIIKP NFKELNKNKN
910 920 930 940 950
VIKEKLDIIS KLTVNDIENI KNGTHDININ ELLIETYIKD IEYSGVFITL

ELF
Length:953
Mass (Da):112,077
Last modified:March 3, 2009 - v1
Checksum:i821531819140DFB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000039 Genomic DNA. Translation: EED43719.1.
RefSeqiXP_002650344.1. XM_002650298.1.

Genome annotation databases

GeneIDi8641969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000039 Genomic DNA. Translation: EED43719.1 .
RefSeqi XP_002650344.1. XM_002650298.1.

3D structure databases

ProteinModelPortali B7XK16.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B7XK16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8641969.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EBI_22873.

Phylogenomic databases

InParanoidi B7XK16.
OrthoDBi EOG7FNCGS.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00392. ileS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
    Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
    PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.
  2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
    Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
    PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.

Entry informationi

Entry nameiSYIC_ENTBH
AccessioniPrimary (citable) accession number: B7XK16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3