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B7XK16

- SYIC_ENTBH

UniProt

B7XK16 - SYIC_ENTBH

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Protein
Probable isoleucine--tRNA ligase, cytoplasmic
Gene
EBI_22873
Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
ORF Names:EBI_22873
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
ProteomesiUP000001742: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_22873.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Probable isoleucine--tRNA ligase, cytoplasmic
PRO_0000388379Add
BLAST

Proteomic databases

PRIDEiB7XK16.

Structurei

3D structure databases

ProteinModelPortaliB7XK16.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" region By similarity
Add
BLAST
Motifi634 – 6385"KMSKS" region By similarity

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7FNCGS.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7XK16-1 [UniParc]FASTAAdd to Basket

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MSDKIIDFSK IEKDILKFWT ENKIFELCNK LSQGREEYVF FDGPPFATGL    50
PHYGHILSGT IKDIIGRFYY QKGFHVERRF GWDCHGLPVE YEIDKKFNIT 100
DRNQILKMGI DVYNHECRKI VQKYTNEWEE TVIRMGRWVD FKGSYKTMDL 150
EFMESIWFIF KELFKRNKIY RGFKIMPFST ACKTALSNFE ASQNYKNVSD 200
PSVLVTFKII NPKDVLHNYE NNDIEIFFVA WTTTPWTLPA NCALVINPDY 250
EYAIFYINNN SKKLYIMLKN RIEVYFKQFC ITTVILGKEL IGVSYATLFN 300
YYENYITRGF FKTIGGNFVT ITDGSGIVHT APAFGEEDYN IFLKLGLLKP 350
DEIPPCHIDE NGKFTIAMEK YVNVPINNDI SLNGVYFKDA DKIILQILKP 400
HLIYNSRIVH SYPFCWRSDT PLLYKLIPNW FVKITDIREE LLTQNKKINW 450
IPETIKYKRF QNWLSNAKDW AISRNRFWGT PLPIWARYEN EIYNYTDLIC 500
VGSIKELEDL TNTKITDLHR EHIDQLLIEH NGKTYKRIED VLDCWFESGS 550
MPYAQNHLKG IKVNNSLIDK LDNINLNNAY LIKENFPADF IGEGLDQTRG 600
WFYTLHVIST ILFNSPAFKN VIVNGIVLAE DGKKMSKRLK NYPDPMNIFN 650
KYGADALRMY LISSPVVEAE NLRFNENGVK EILKTLLIPW YNTLVFYKEC 700
QIQNHNHTLL LDAWIESELN ILINKVNIDM SEYKLNNILN YALDFIENLN 750
NWYIRINRKE LKNNGLYLKT IIKRFSIVMS AFVPFFSDYS YQIVCSDKIS 800
VHLEMIPEYK SINSDFNFIK CIIDGIRHLR EKYKLKLKKT LKEVIIVLDN 850
ININKNLFEK YEAVIKSECN TLDIILNDIN DYSISTIIKP NFKELNKNKN 900
VIKEKLDIIS KLTVNDIENI KNGTHDININ ELLIETYIKD IEYSGVFITL 950
ELF 953
Length:953
Mass (Da):112,077
Last modified:March 3, 2009 - v1
Checksum:i821531819140DFB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000039 Genomic DNA. Translation: EED43719.1.
RefSeqiXP_002650344.1. XM_002650298.1.

Genome annotation databases

GeneIDi8641969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000039 Genomic DNA. Translation: EED43719.1 .
RefSeqi XP_002650344.1. XM_002650298.1.

3D structure databases

ProteinModelPortali B7XK16.
ModBasei Search...

Proteomic databases

PRIDEi B7XK16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8641969.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EBI_22873.

Phylogenomic databases

OrthoDBi EOG7FNCGS.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00392. ileS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
    Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
    PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.
  2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
    Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
    PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.

Entry informationi

Entry nameiSYIC_ENTBH
AccessioniPrimary (citable) accession number: B7XK16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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