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B7XK16

- SYIC_ENTBH

UniProt

B7XK16 - SYIC_ENTBH

Protein

Probable isoleucine--tRNA ligase, cytoplasmic

Gene

EBI_22873

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei637 – 6371ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
    Alternative name(s):
    Isoleucyl-tRNA synthetase
    Short name:
    IleRS
    Gene namesi
    ORF Names:EBI_22873
    OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
    Taxonomic identifieri481877 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
    ProteomesiUP000001742: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:EBI_22873.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 953953Probable isoleucine--tRNA ligase, cytoplasmicPRO_0000388379Add
    BLAST

    Proteomic databases

    PRIDEiB7XK16.

    Structurei

    3D structure databases

    ProteinModelPortaliB7XK16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 5511"HIGH" regionBy similarityAdd
    BLAST
    Motifi634 – 6385"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG7FNCGS.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00984. TRNASYNTHILE.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00392. ileS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7XK16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKIIDFSK IEKDILKFWT ENKIFELCNK LSQGREEYVF FDGPPFATGL    50
    PHYGHILSGT IKDIIGRFYY QKGFHVERRF GWDCHGLPVE YEIDKKFNIT 100
    DRNQILKMGI DVYNHECRKI VQKYTNEWEE TVIRMGRWVD FKGSYKTMDL 150
    EFMESIWFIF KELFKRNKIY RGFKIMPFST ACKTALSNFE ASQNYKNVSD 200
    PSVLVTFKII NPKDVLHNYE NNDIEIFFVA WTTTPWTLPA NCALVINPDY 250
    EYAIFYINNN SKKLYIMLKN RIEVYFKQFC ITTVILGKEL IGVSYATLFN 300
    YYENYITRGF FKTIGGNFVT ITDGSGIVHT APAFGEEDYN IFLKLGLLKP 350
    DEIPPCHIDE NGKFTIAMEK YVNVPINNDI SLNGVYFKDA DKIILQILKP 400
    HLIYNSRIVH SYPFCWRSDT PLLYKLIPNW FVKITDIREE LLTQNKKINW 450
    IPETIKYKRF QNWLSNAKDW AISRNRFWGT PLPIWARYEN EIYNYTDLIC 500
    VGSIKELEDL TNTKITDLHR EHIDQLLIEH NGKTYKRIED VLDCWFESGS 550
    MPYAQNHLKG IKVNNSLIDK LDNINLNNAY LIKENFPADF IGEGLDQTRG 600
    WFYTLHVIST ILFNSPAFKN VIVNGIVLAE DGKKMSKRLK NYPDPMNIFN 650
    KYGADALRMY LISSPVVEAE NLRFNENGVK EILKTLLIPW YNTLVFYKEC 700
    QIQNHNHTLL LDAWIESELN ILINKVNIDM SEYKLNNILN YALDFIENLN 750
    NWYIRINRKE LKNNGLYLKT IIKRFSIVMS AFVPFFSDYS YQIVCSDKIS 800
    VHLEMIPEYK SINSDFNFIK CIIDGIRHLR EKYKLKLKKT LKEVIIVLDN 850
    ININKNLFEK YEAVIKSECN TLDIILNDIN DYSISTIIKP NFKELNKNKN 900
    VIKEKLDIIS KLTVNDIENI KNGTHDININ ELLIETYIKD IEYSGVFITL 950
    ELF 953
    Length:953
    Mass (Da):112,077
    Last modified:March 3, 2009 - v1
    Checksum:i821531819140DFB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGB01000039 Genomic DNA. Translation: EED43719.1.
    RefSeqiXP_002650344.1. XM_002650298.1.

    Genome annotation databases

    GeneIDi8641969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGB01000039 Genomic DNA. Translation: EED43719.1 .
    RefSeqi XP_002650344.1. XM_002650298.1.

    3D structure databases

    ProteinModelPortali B7XK16.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B7XK16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8641969.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:EBI_22873.

    Phylogenomic databases

    OrthoDBi EOG7FNCGS.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00984. TRNASYNTHILE.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00392. ileS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
      Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
      PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H348.
    2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
      Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
      PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H348.

    Entry informationi

    Entry nameiSYIC_ENTBH
    AccessioniPrimary (citable) accession number: B7XK16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3