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Protein

Probable isoleucine--tRNA ligase, cytoplasmic

Gene

EBI_22873

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei637ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
ORF Names:EBI_22873
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaEnterocytozoonidaeEnterocytozoon
Proteomesi
  • UP000001742 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_22873

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003883791 – 953Probable isoleucine--tRNA ligase, cytoplasmicAdd BLAST953

Proteomic databases

PRIDEiB7XK16

Structurei

3D structure databases

ProteinModelPortaliB7XK16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 55"HIGH" regionBy similarityAdd BLAST11
Motifi634 – 638"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiB7XK16
OrthoDBiEOG092C0CHR

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002301 Ile-tRNA-ligase
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00984 TRNASYNTHILE
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00392 ileS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B7XK16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKIIDFSK IEKDILKFWT ENKIFELCNK LSQGREEYVF FDGPPFATGL
60 70 80 90 100
PHYGHILSGT IKDIIGRFYY QKGFHVERRF GWDCHGLPVE YEIDKKFNIT
110 120 130 140 150
DRNQILKMGI DVYNHECRKI VQKYTNEWEE TVIRMGRWVD FKGSYKTMDL
160 170 180 190 200
EFMESIWFIF KELFKRNKIY RGFKIMPFST ACKTALSNFE ASQNYKNVSD
210 220 230 240 250
PSVLVTFKII NPKDVLHNYE NNDIEIFFVA WTTTPWTLPA NCALVINPDY
260 270 280 290 300
EYAIFYINNN SKKLYIMLKN RIEVYFKQFC ITTVILGKEL IGVSYATLFN
310 320 330 340 350
YYENYITRGF FKTIGGNFVT ITDGSGIVHT APAFGEEDYN IFLKLGLLKP
360 370 380 390 400
DEIPPCHIDE NGKFTIAMEK YVNVPINNDI SLNGVYFKDA DKIILQILKP
410 420 430 440 450
HLIYNSRIVH SYPFCWRSDT PLLYKLIPNW FVKITDIREE LLTQNKKINW
460 470 480 490 500
IPETIKYKRF QNWLSNAKDW AISRNRFWGT PLPIWARYEN EIYNYTDLIC
510 520 530 540 550
VGSIKELEDL TNTKITDLHR EHIDQLLIEH NGKTYKRIED VLDCWFESGS
560 570 580 590 600
MPYAQNHLKG IKVNNSLIDK LDNINLNNAY LIKENFPADF IGEGLDQTRG
610 620 630 640 650
WFYTLHVIST ILFNSPAFKN VIVNGIVLAE DGKKMSKRLK NYPDPMNIFN
660 670 680 690 700
KYGADALRMY LISSPVVEAE NLRFNENGVK EILKTLLIPW YNTLVFYKEC
710 720 730 740 750
QIQNHNHTLL LDAWIESELN ILINKVNIDM SEYKLNNILN YALDFIENLN
760 770 780 790 800
NWYIRINRKE LKNNGLYLKT IIKRFSIVMS AFVPFFSDYS YQIVCSDKIS
810 820 830 840 850
VHLEMIPEYK SINSDFNFIK CIIDGIRHLR EKYKLKLKKT LKEVIIVLDN
860 870 880 890 900
ININKNLFEK YEAVIKSECN TLDIILNDIN DYSISTIIKP NFKELNKNKN
910 920 930 940 950
VIKEKLDIIS KLTVNDIENI KNGTHDININ ELLIETYIKD IEYSGVFITL

ELF
Length:953
Mass (Da):112,077
Last modified:March 3, 2009 - v1
Checksum:i821531819140DFB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGB01000039 Genomic DNA Translation: EED43719.1
RefSeqiXP_002650344.1, XM_002650298.1

Genome annotation databases

EnsemblFungiiEED43719; EED43719; EBI_22873

Entry informationi

Entry nameiSYIC_ENTBH
AccessioniPrimary (citable) accession number: B7XK16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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