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B7XHP6

- SYLC_ENTBH

UniProt

B7XHP6 - SYLC_ENTBH

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Protein
Probable leucine--tRNA ligase, cytoplasmic
Gene
EBI_21702
Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei555 – 5551ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. leucine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
ORF Names:EBI_21702
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
ProteomesiUP000001742: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_21702.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Probable leucine--tRNA ligase, cytoplasmic
PRO_0000388414Add
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" region By similarity
Add
BLAST
Motifi552 – 5565"KMSKS" region By similarity

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7TTQH2.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7XHP6-1 [UniParc]FASTAAdd to Basket

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MSENNTKLKY LCDLEEKGRR QCMESEILVD KKKFFITFPY PYMNGKLHLG    50
HLFSISKADI FSYYKEMQGF NVLFPFGFHC TGMPISASAK KLKMELANEG 100
EIDISVVNIL KSLGFKLYCS GKCTNVECIC QFTDPFHWCR TFPKYCKASL 150
VKYDANIDWR RSFITTDVNP YYDSFVKYQF TKLKNCNYIS FGKRYSIFCP 200
VDNQICLDHD RRKGEGVKPI PIVLAILGNN ILVPVQEKDL NTIIDNNVEI 250
VTQKEIQWIQ FSINNDVYVA EEDIYNNIKY QVENVYKIKT VTLDGLYPYI 300
IYVNSNIRKS KINNKNKILT ENIYNKLIAD RHEKMELIKY DKFIVCYVPE 350
DTVISRSGGK CTVALMDQWF LDYSNPEWKE KTKICLNKLT ASKDTKEKLE 400
LALNWINKWG FSRNFGLGTK FPYDNSVLID SLSDSTIYMA FYTVKHLLFK 450
DLEGKEPLFP IKYMGYAFWE YVFGNSNEIN FIDPNDLNAK KIVEDARSQF 500
NYFYPIDLRV SGKDLINNHL IFFLMNHVAI FKENNWPKRI YTNGHLLLNG 550
LKMSKSEGNF LSVDTALERF GTSATRMCLA ICGDTNEDAN FVESMANSFV 600
LKLYTLSQNI FLISSNNQSV NVADYTLIDY YLISSIKINE EKTFTSYENI 650
VYRDVIKYGF YNNLDTIETY EMFGGSNSNL KHWAYYNMMK QLYPVIPSLA 700
RYFLNEVLTD ISIEFKNIIN QQYISGIEYI KELIHKINKF TKHDAKKVNL 750
TLIKHYPPWK ELCMKKIDEL KLIHKNNNDL KKIVLKECSQ FIGENNRKKG 800
ILFCMDYLLY KEKYIINFDE ELYTNTFKSI IEQETKKKII ILIKDDSTKG 850
EPLCPEINSC 860
Length:860
Mass (Da):100,606
Last modified:March 3, 2009 - v1
Checksum:i2362357DA934B50A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000015 Genomic DNA. Translation: EED44543.1.
RefSeqiXP_002649524.1. XM_002649478.1.

Genome annotation databases

GeneIDi8641125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000015 Genomic DNA. Translation: EED44543.1 .
RefSeqi XP_002649524.1. XM_002649478.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8641125.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EBI_21702.

Phylogenomic databases

OrthoDBi EOG7TTQH2.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
    Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
    PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.
  2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
    Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
    PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.

Entry informationi

Entry nameiSYLC_ENTBH
AccessioniPrimary (citable) accession number: B7XHP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: November 13, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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