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B7XHP6

- SYLC_ENTBH

UniProt

B7XHP6 - SYLC_ENTBH

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Protein

Probable leucine--tRNA ligase, cytoplasmic

Gene

EBI_21702

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei555 – 5551ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
ORF Names:EBI_21702
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
ProteomesiUP000001742: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_21702.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Probable leucine--tRNA ligase, cytoplasmicPRO_0000388414Add
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionBy similarityAdd
BLAST
Motifi552 – 5565"KMSKS" regionBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiB7XHP6.
OrthoDBiEOG7TTQH2.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7XHP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENNTKLKY LCDLEEKGRR QCMESEILVD KKKFFITFPY PYMNGKLHLG
60 70 80 90 100
HLFSISKADI FSYYKEMQGF NVLFPFGFHC TGMPISASAK KLKMELANEG
110 120 130 140 150
EIDISVVNIL KSLGFKLYCS GKCTNVECIC QFTDPFHWCR TFPKYCKASL
160 170 180 190 200
VKYDANIDWR RSFITTDVNP YYDSFVKYQF TKLKNCNYIS FGKRYSIFCP
210 220 230 240 250
VDNQICLDHD RRKGEGVKPI PIVLAILGNN ILVPVQEKDL NTIIDNNVEI
260 270 280 290 300
VTQKEIQWIQ FSINNDVYVA EEDIYNNIKY QVENVYKIKT VTLDGLYPYI
310 320 330 340 350
IYVNSNIRKS KINNKNKILT ENIYNKLIAD RHEKMELIKY DKFIVCYVPE
360 370 380 390 400
DTVISRSGGK CTVALMDQWF LDYSNPEWKE KTKICLNKLT ASKDTKEKLE
410 420 430 440 450
LALNWINKWG FSRNFGLGTK FPYDNSVLID SLSDSTIYMA FYTVKHLLFK
460 470 480 490 500
DLEGKEPLFP IKYMGYAFWE YVFGNSNEIN FIDPNDLNAK KIVEDARSQF
510 520 530 540 550
NYFYPIDLRV SGKDLINNHL IFFLMNHVAI FKENNWPKRI YTNGHLLLNG
560 570 580 590 600
LKMSKSEGNF LSVDTALERF GTSATRMCLA ICGDTNEDAN FVESMANSFV
610 620 630 640 650
LKLYTLSQNI FLISSNNQSV NVADYTLIDY YLISSIKINE EKTFTSYENI
660 670 680 690 700
VYRDVIKYGF YNNLDTIETY EMFGGSNSNL KHWAYYNMMK QLYPVIPSLA
710 720 730 740 750
RYFLNEVLTD ISIEFKNIIN QQYISGIEYI KELIHKINKF TKHDAKKVNL
760 770 780 790 800
TLIKHYPPWK ELCMKKIDEL KLIHKNNNDL KKIVLKECSQ FIGENNRKKG
810 820 830 840 850
ILFCMDYLLY KEKYIINFDE ELYTNTFKSI IEQETKKKII ILIKDDSTKG
860
EPLCPEINSC
Length:860
Mass (Da):100,606
Last modified:March 3, 2009 - v1
Checksum:i2362357DA934B50A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGB01000015 Genomic DNA. Translation: EED44543.1.
RefSeqiXP_002649524.1. XM_002649478.1.

Genome annotation databases

GeneIDi8641125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGB01000015 Genomic DNA. Translation: EED44543.1 .
RefSeqi XP_002649524.1. XM_002649478.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8641125.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EBI_21702.

Phylogenomic databases

InParanoidi B7XHP6.
OrthoDBi EOG7TTQH2.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
    Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
    PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.
  2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
    Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
    PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.

Entry informationi

Entry nameiSYLC_ENTBH
AccessioniPrimary (citable) accession number: B7XHP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3