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B7XHP6

- SYLC_ENTBH

UniProt

B7XHP6 - SYLC_ENTBH

Protein

Probable leucine--tRNA ligase, cytoplasmic

Gene

EBI_21702

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei555 – 5551ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. leucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA aminoacylation for protein translation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase
    Short name:
    LeuRS
    Gene namesi
    ORF Names:EBI_21702
    OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
    Taxonomic identifieri481877 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
    ProteomesiUP000001742: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:EBI_21702.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 860860Probable leucine--tRNA ligase, cytoplasmicPRO_0000388414Add
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionBy similarityAdd
    BLAST
    Motifi552 – 5565"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG7TTQH2.

    Family and domain databases

    Gene3Di3.40.50.620. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7XHP6-1 [UniParc]FASTAAdd to Basket

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    MSENNTKLKY LCDLEEKGRR QCMESEILVD KKKFFITFPY PYMNGKLHLG    50
    HLFSISKADI FSYYKEMQGF NVLFPFGFHC TGMPISASAK KLKMELANEG 100
    EIDISVVNIL KSLGFKLYCS GKCTNVECIC QFTDPFHWCR TFPKYCKASL 150
    VKYDANIDWR RSFITTDVNP YYDSFVKYQF TKLKNCNYIS FGKRYSIFCP 200
    VDNQICLDHD RRKGEGVKPI PIVLAILGNN ILVPVQEKDL NTIIDNNVEI 250
    VTQKEIQWIQ FSINNDVYVA EEDIYNNIKY QVENVYKIKT VTLDGLYPYI 300
    IYVNSNIRKS KINNKNKILT ENIYNKLIAD RHEKMELIKY DKFIVCYVPE 350
    DTVISRSGGK CTVALMDQWF LDYSNPEWKE KTKICLNKLT ASKDTKEKLE 400
    LALNWINKWG FSRNFGLGTK FPYDNSVLID SLSDSTIYMA FYTVKHLLFK 450
    DLEGKEPLFP IKYMGYAFWE YVFGNSNEIN FIDPNDLNAK KIVEDARSQF 500
    NYFYPIDLRV SGKDLINNHL IFFLMNHVAI FKENNWPKRI YTNGHLLLNG 550
    LKMSKSEGNF LSVDTALERF GTSATRMCLA ICGDTNEDAN FVESMANSFV 600
    LKLYTLSQNI FLISSNNQSV NVADYTLIDY YLISSIKINE EKTFTSYENI 650
    VYRDVIKYGF YNNLDTIETY EMFGGSNSNL KHWAYYNMMK QLYPVIPSLA 700
    RYFLNEVLTD ISIEFKNIIN QQYISGIEYI KELIHKINKF TKHDAKKVNL 750
    TLIKHYPPWK ELCMKKIDEL KLIHKNNNDL KKIVLKECSQ FIGENNRKKG 800
    ILFCMDYLLY KEKYIINFDE ELYTNTFKSI IEQETKKKII ILIKDDSTKG 850
    EPLCPEINSC 860
    Length:860
    Mass (Da):100,606
    Last modified:March 3, 2009 - v1
    Checksum:i2362357DA934B50A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGB01000015 Genomic DNA. Translation: EED44543.1.
    RefSeqiXP_002649524.1. XM_002649478.1.

    Genome annotation databases

    GeneIDi8641125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGB01000015 Genomic DNA. Translation: EED44543.1 .
    RefSeqi XP_002649524.1. XM_002649478.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8641125.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:EBI_21702.

    Phylogenomic databases

    OrthoDBi EOG7TTQH2.

    Family and domain databases

    Gene3Di 3.40.50.620. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
      Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
      PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H348.
    2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
      Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
      PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H348.

    Entry informationi

    Entry nameiSYLC_ENTBH
    AccessioniPrimary (citable) accession number: B7XHP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3