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Protein
Submitted name:

Cytosolic phospholipase A2 epsilon

Gene

PLA2G4E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. phospholipase A2 activity Source: Ensembl

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cytosolic phospholipase A2 epsilonImported
Gene namesi
Name:PLA2G4EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:24791. PLA2G4E.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB7WPN2.

Expressioni

Gene expression databases

BgeeiB7WPN2.

Structurei

3D structure databases

ProteinModelPortaliB7WPN2.
SMRiB7WPN2. Positions 59-150, 317-861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074489.
HOGENOMiHOG000231788.
HOVERGENiHBG080412.
KOiK16342.
OMAiYPKYFQP.
OrthoDBiEOG7Z0JVQ.
PhylomeDBiB7WPN2.
TreeFamiTF325228.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7WPN2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLQASEGCP GLGTNVFVPQ SPQTDEEGSR SGRSFSEFED TQDLDTPGLP
60 70 80 90 100
PFCPMAPWGS EEGLSPCHLL TVRVIRMKNV RQADMLSQTD CFVSLWLPTA
110 120 130 140 150
SQKKLRTRTI SNCPNPEWNE SFNFQIQSRV KNVLELSVCD EDTVTPDDHL
160 170 180 190 200
LTVLYDLTKL CFRKKTHVKF PLNPQGMEEL EVEFLLEESP SPPETLVTNG
210 220 230 240 250
VLVSRQVSCL EVHAQSRRRR KREKMKDLLV MVNESFENTQ RVRPCLEPCC
260 270 280 290 300
PTSACFQTAA CFHYPKYFQS QVHVEVPKSH WSCGLCCRSR KKGPISQPLD
310 320 330 340 350
CLSDGQVMTL PVGESYELHM KSTPCPETLD VRLGFSLCPA ELEFLQKRKV
360 370 380 390 400
VVAKALKQVL QLEEDLQEDE VPLIAIMATG GGTRSMTSMY GHLLGLQKLN
410 420 430 440 450
LLDCASYITG LSGATWTMAT LYRDPDWSSK NLEPAIFEAR RHVVKDKLPS
460 470 480 490 500
LFPDQLRKFQ EELRQRSQEG YRVTFTDFWG LLIETCLGDE RNECKLSDQR
510 520 530 540 550
AALSCGQNPL PIYLTINVKD DVSNQDFREW FEFSPYEVGL QKYGAFIPSE
560 570 580 590 600
LFGSEFFMGR LVKRIPESRI CYMLGLWSSI FSLNLLDAWN LSHTSEEFFH
610 620 630 640 650
RWTREKVQDI EDEPILPEIP KCDANILETT VVIPGSWLSN SFREILTHRS
660 670 680 690 700
FVSEFHNFLS GLQLHTNYLQ NGQFSRWKDT VLDGFPNQLT ESANHLCLLD
710 720 730 740 750
TAFFVNSSYP PLLRPERKAD LIIHLNYCAG SQTKPLKQTC EYCTVQNIPF
760 770 780 790 800
PKYELPDENE NLKECYLMEN PQEPDAPIVT FFPLINDTFR KYKAPGVERS
810 820 830 840 850
PEELEQGQVD IYGPKTPYAT KELTYTEATF DKLVKLSEYN ILNNKDTLLQ
860
ALRLAVEKKK RLKGQCPS
Length:868
Mass (Da):99,190
Last modified:February 10, 2009 - v1
Checksum:iF9A6F33880A5409F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC039056 Genomic DNA. No translation available.
RefSeqiNP_001193599.1. NM_001206670.1.
UniGeneiHs.668060.

Genome annotation databases

EnsembliENST00000399518; ENSP00000382434; ENSG00000188089.
GeneIDi123745.
KEGGihsa:123745.
UCSCiuc021sjp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC039056 Genomic DNA. No translation available.
RefSeqiNP_001193599.1. NM_001206670.1.
UniGeneiHs.668060.

3D structure databases

ProteinModelPortaliB7WPN2.
SMRiB7WPN2. Positions 59-150, 317-861.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB7WPN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399518; ENSP00000382434; ENSG00000188089.
GeneIDi123745.
KEGGihsa:123745.
UCSCiuc021sjp.1. human.

Organism-specific databases

CTDi123745.
HGNCiHGNC:24791. PLA2G4E.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074489.
HOGENOMiHOG000231788.
HOVERGENiHBG080412.
KOiK16342.
OMAiYPKYFQP.
OrthoDBiEOG7Z0JVQ.
PhylomeDBiB7WPN2.
TreeFamiTF325228.

Miscellaneous databases

GenomeRNAii123745.
NextBioi81141.

Gene expression databases

BgeeiB7WPN2.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7WPN2_HUMAN
AccessioniPrimary (citable) accession number: B7WPN2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.