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Protein

Pyruvate kinase

Gene

pyk-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 2 (gpd-2), Glyceraldehyde-3-phosphate dehydrogenase 4 (gpd-4), Glyceraldehyde-3-phosphate dehydrogenase 3 (gpd-3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gpd-1)
  2. Probable phosphoglycerate kinase (pgk-1)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)
  4. Enolase (enol-1)
  5. Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
R-CEL-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pyk-1Imported
ORF Names:CELE_F25H5.3Imported, F25H5.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H5.3e; CE43392; WBGene00009126; pyk-1.

Subcellular locationi

PTM / Processingi

Proteomic databases

EPDiB7WNA0.
PaxDbiB7WNA0.
PeptideAtlasiB7WNA0.

Expressioni

Gene expression databases

BgeeiWBGene00009126.
ExpressionAtlasiB7WNA0. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F25H5.3e.

Structurei

3D structure databases

ProteinModelPortaliB7WNA0.
SMRiB7WNA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini429 – 776PKInterPro annotationAdd BLAST348
Domaini793 – 910PK_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
InParanoidiB7WNA0.
OrthoDBiEOG091G0597.

Family and domain databases

CDDicd00288. Pyruvate_Kinase. 1 hit.
Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

B7WNA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLHGPSVA PIEATNGSFR RLEVCQSCGK QDEPMIRASS AEELTETAIE
60 70 80 90 100
SALTSLHAEQ PNTSTVHRLD RSRTFDKDWD LHPDAVICKA CIFESLYPEN
110 120 130 140 150
CDNDSEKFRE TDISNMRMSS EEFEFIDGGS GIIIEEIEDD DEGTSQNPQN
160 170 180 190 200
HSWEDIPVKG LMENNESFET VILQKMEVTN DVVLTGTPAI YIETSEVAKE
210 220 230 240 250
PESIWSVRRP LSIDSINTPI VPKILTPEDY LKEKQEDRRQ SFVTPLEELY
260 270 280 290 300
KKYNHQPISQ NGLIRVIQTP PPPCRFSTFG HLRRTSSCGT IETYGDALKR
310 320 330 340 350
RSFWYIDENS ETSESRQGSQ AEDENDNSIV IEVEESISGV DCTFCSSFWN
360 370 380 390 400
FMKCKWVLGS ELAEAGDTIN EVKASSASGR GRLARRMTIE EEHAGDYFKQ
410 420 430 440 450
EQKLAAVPAT THMEHLCRLD IREAPHLVRQ TGIICTIGPA CASVEMLQKL
460 470 480 490 500
ILNGMNIARL NFSHGSHEYH AGTIANVREA ADSFSDKRVI GIALDTKGPE
510 520 530 540 550
IRTGLLAGGA SAEIELARGA SIRLTTDPHF SESGTAVNLF VDYKNIAKVL
560 570 580 590 600
SVGSRVYIDD GLISLIVEEL QTDAVICSVE NGGMLGSRKG VNLPGTIVDL
610 620 630 640 650
PAVSEKDCKD LQFGVEQGVD IIFASFIRNA EGIRTIRKVL GEKGKKIKII
660 670 680 690 700
AKIENQEGVD NADEIISESD GVMVARGDLG IEIPAEKVFL AQKMLISKCN
710 720 730 740 750
RAGKPVICAT QMLESMVHKP RPTRAEGSDV ANAVLDGADC VMLSGETAKG
760 770 780 790 800
EYPVDALKIM HYICKEAEAA VYHRRLFDEL LQNTQKPTDM SHTIAIAATS
810 820 830 840 850
AAASCHASAI LLITTTGRSA IQCSRYKPAV PILTISRDVA VCRQLHLYRG
860 870 880 890 900
VFPVHYPAER AADWPTDVDN RINHAIAIGK DRGFIHKGDF LVVVTGWRQG
910
AGATNTLRII TAE
Length:913
Mass (Da):100,588
Last modified:February 10, 2009 - v1
Checksum:iC496A3E88D956DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAV31772.1.
RefSeqiNP_001251014.1. NM_001264085.1.
UniGeneiCel.17414.

Genome annotation databases

EnsemblMetazoaiF25H5.3e; F25H5.3e; WBGene00009126.
GeneIDi172744.

Similar proteinsi

Entry informationi

Entry nameiB7WNA0_CAEEL
AccessioniPrimary (citable) accession number: B7WNA0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: August 30, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported