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B7VSJ2

- FTHS_VIBSL

UniProt

B7VSJ2 - FTHS_VIBSL

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, VS_II0809
Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVSPL575788:GH64-3889-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:VS_II0809
OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000185271Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi575788.VS_II0809.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7VSJ2-1 [UniParc]FASTAAdd to Basket

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MLSDIDICRS TPLKNISEVA KQAGLHHNEH QPLGQYKSKV SLTSLERLAS    50
QQDGKLVVVT AITPTPLGEG KTVTTIGLAQ GLAKINQSAM ACIRQPSMGP 100
VFGVKGGAAG GGYSQVAPME QLNLHLTGDI HAVTVAHNLA SAAIDARLYH 150
EQREGLEAFE ARSGLKALDI DPRRIVWRRV LDHNDRALRM ITVGKNEADK 200
TINGFEREDG FDISAASELM AILALTDDLQ DLRKRIGRVV LAYNNQGLPL 250
TADDFNVAGA MTVTMKDSIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
ADKIALKLSD FVVTEGGFGS DMGFEKACNI KVKASNKKPD CAVIVATLRG 350
LKANSGLYDL RPGTPLPDSI FNDDQDALIA GFENLKWHIN NVKQYQVPTV 400
VAINRFPQDS AQELNALKQM ITDFDPSVSV EVSEAFGQGG EGATQLAHAV 450
VKACQKQSEF KPLYHSEQSL EEKLMAVAEV GYGAASISLS PLAKKQLAEF 500
KLHGYSDLSV CLAKTPLSIS TEAHIKGAPS QFDVPVRELK LCAGAGFIYA 550
LCGNVMTMPG LPDKPAFMSL DIDSKGNIVG LS 582
Length:582
Mass (Da):62,374
Last modified:February 10, 2009 - v1
Checksum:i742337700BC834BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954973 Genomic DNA. Translation: CAV26568.1.
RefSeqiYP_002395391.1. NC_011744.2.

Genome annotation databases

EnsemblBacteriaiCAV26568; CAV26568; VS_II0809.
GeneIDi7138100.
KEGGivsp:VS_II0809.
PATRICi20149428. VBIVibSpl48387_0764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954973 Genomic DNA. Translation: CAV26568.1 .
RefSeqi YP_002395391.1. NC_011744.2.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 575788.VS_II0809.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV26568 ; CAV26568 ; VS_II0809 .
GeneIDi 7138100.
KEGGi vsp:VS_II0809.
PATRICi 20149428. VBIVibSpl48387_0764.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci VSPL575788:GH64-3889-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiFTHS_VIBSL
AccessioniPrimary (citable) accession number: B7VSJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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