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B7VSJ2

- FTHS_VIBSL

UniProt

B7VSJ2 - FTHS_VIBSL

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVSPL575788:GH64-3889-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:VS_II0809
    OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
    Taxonomic identifieri575788 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000009100: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_1000185271Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi575788.VS_II0809.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7VSJ2-1 [UniParc]FASTAAdd to Basket

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    MLSDIDICRS TPLKNISEVA KQAGLHHNEH QPLGQYKSKV SLTSLERLAS    50
    QQDGKLVVVT AITPTPLGEG KTVTTIGLAQ GLAKINQSAM ACIRQPSMGP 100
    VFGVKGGAAG GGYSQVAPME QLNLHLTGDI HAVTVAHNLA SAAIDARLYH 150
    EQREGLEAFE ARSGLKALDI DPRRIVWRRV LDHNDRALRM ITVGKNEADK 200
    TINGFEREDG FDISAASELM AILALTDDLQ DLRKRIGRVV LAYNNQGLPL 250
    TADDFNVAGA MTVTMKDSIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
    ADKIALKLSD FVVTEGGFGS DMGFEKACNI KVKASNKKPD CAVIVATLRG 350
    LKANSGLYDL RPGTPLPDSI FNDDQDALIA GFENLKWHIN NVKQYQVPTV 400
    VAINRFPQDS AQELNALKQM ITDFDPSVSV EVSEAFGQGG EGATQLAHAV 450
    VKACQKQSEF KPLYHSEQSL EEKLMAVAEV GYGAASISLS PLAKKQLAEF 500
    KLHGYSDLSV CLAKTPLSIS TEAHIKGAPS QFDVPVRELK LCAGAGFIYA 550
    LCGNVMTMPG LPDKPAFMSL DIDSKGNIVG LS 582
    Length:582
    Mass (Da):62,374
    Last modified:February 10, 2009 - v1
    Checksum:i742337700BC834BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM954973 Genomic DNA. Translation: CAV26568.1.
    RefSeqiYP_002395391.1. NC_011744.2.

    Genome annotation databases

    EnsemblBacteriaiCAV26568; CAV26568; VS_II0809.
    GeneIDi7138100.
    KEGGivsp:VS_II0809.
    PATRICi20149428. VBIVibSpl48387_0764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM954973 Genomic DNA. Translation: CAV26568.1 .
    RefSeqi YP_002395391.1. NC_011744.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 575788.VS_II0809.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAV26568 ; CAV26568 ; VS_II0809 .
    GeneIDi 7138100.
    KEGGi vsp:VS_II0809.
    PATRICi 20149428. VBIVibSpl48387_0764.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci VSPL575788:GH64-3889-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vibrio splendidus str. LGP32 complete genome."
      Mazel D., Le Roux F.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LGP32.

    Entry informationi

    Entry nameiFTHS_VIBSL
    AccessioniPrimary (citable) accession number: B7VSJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3