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B7VSJ2 (FTHS_VIBSL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:VS_II0809
OrganismVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32)) [Complete proteome] [HAMAP]
Taxonomic identifier575788 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185271

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B7VSJ2 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 742337700BC834BA

FASTA58262,374
        10         20         30         40         50         60 
MLSDIDICRS TPLKNISEVA KQAGLHHNEH QPLGQYKSKV SLTSLERLAS QQDGKLVVVT 

        70         80         90        100        110        120 
AITPTPLGEG KTVTTIGLAQ GLAKINQSAM ACIRQPSMGP VFGVKGGAAG GGYSQVAPME 

       130        140        150        160        170        180 
QLNLHLTGDI HAVTVAHNLA SAAIDARLYH EQREGLEAFE ARSGLKALDI DPRRIVWRRV 

       190        200        210        220        230        240 
LDHNDRALRM ITVGKNEADK TINGFEREDG FDISAASELM AILALTDDLQ DLRKRIGRVV 

       250        260        270        280        290        300 
LAYNNQGLPL TADDFNVAGA MTVTMKDSIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 

       310        320        330        340        350        360 
ADKIALKLSD FVVTEGGFGS DMGFEKACNI KVKASNKKPD CAVIVATLRG LKANSGLYDL 

       370        380        390        400        410        420 
RPGTPLPDSI FNDDQDALIA GFENLKWHIN NVKQYQVPTV VAINRFPQDS AQELNALKQM 

       430        440        450        460        470        480 
ITDFDPSVSV EVSEAFGQGG EGATQLAHAV VKACQKQSEF KPLYHSEQSL EEKLMAVAEV 

       490        500        510        520        530        540 
GYGAASISLS PLAKKQLAEF KLHGYSDLSV CLAKTPLSIS TEAHIKGAPS QFDVPVRELK 

       550        560        570        580 
LCAGAGFIYA LCGNVMTMPG LPDKPAFMSL DIDSKGNIVG LS 

« Hide

References

[1]"Vibrio splendidus str. LGP32 complete genome."
Mazel D., Le Roux F.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LGP32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM954973 Genomic DNA. Translation: CAV26568.1.
RefSeqYP_002395391.1. NC_011744.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING575788.VS_II0809.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAV26568; CAV26568; VS_II0809.
GeneID7138100.
KEGGvsp:VS_II0809.
PATRIC20149428. VBIVibSpl48387_0764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycVSPL575788:GH64-3889-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_VIBSL
AccessionPrimary (citable) accession number: B7VSJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways