Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVSPL575788:GH64-3889-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:VS_II0809
OrganismiVibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_1000185271Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi575788.VS_II0809.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGNSKSGE.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7VSJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDIDICRS TPLKNISEVA KQAGLHHNEH QPLGQYKSKV SLTSLERLAS
60 70 80 90 100
QQDGKLVVVT AITPTPLGEG KTVTTIGLAQ GLAKINQSAM ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYSQVAPME QLNLHLTGDI HAVTVAHNLA SAAIDARLYH
160 170 180 190 200
EQREGLEAFE ARSGLKALDI DPRRIVWRRV LDHNDRALRM ITVGKNEADK
210 220 230 240 250
TINGFEREDG FDISAASELM AILALTDDLQ DLRKRIGRVV LAYNNQGLPL
260 270 280 290 300
TADDFNVAGA MTVTMKDSIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII
310 320 330 340 350
ADKIALKLSD FVVTEGGFGS DMGFEKACNI KVKASNKKPD CAVIVATLRG
360 370 380 390 400
LKANSGLYDL RPGTPLPDSI FNDDQDALIA GFENLKWHIN NVKQYQVPTV
410 420 430 440 450
VAINRFPQDS AQELNALKQM ITDFDPSVSV EVSEAFGQGG EGATQLAHAV
460 470 480 490 500
VKACQKQSEF KPLYHSEQSL EEKLMAVAEV GYGAASISLS PLAKKQLAEF
510 520 530 540 550
KLHGYSDLSV CLAKTPLSIS TEAHIKGAPS QFDVPVRELK LCAGAGFIYA
560 570 580
LCGNVMTMPG LPDKPAFMSL DIDSKGNIVG LS
Length:582
Mass (Da):62,374
Last modified:February 9, 2009 - v1
Checksum:i742337700BC834BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954973 Genomic DNA. Translation: CAV26568.1.
RefSeqiYP_002395391.1. NC_011744.2.

Genome annotation databases

EnsemblBacteriaiCAV26568; CAV26568; VS_II0809.
KEGGivsp:VS_II0809.
PATRICi20149428. VBIVibSpl48387_0764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954973 Genomic DNA. Translation: CAV26568.1.
RefSeqiYP_002395391.1. NC_011744.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi575788.VS_II0809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAV26568; CAV26568; VS_II0809.
KEGGivsp:VS_II0809.
PATRICi20149428. VBIVibSpl48387_0764.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGNSKSGE.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciVSPL575788:GH64-3889-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiFTHS_VIBTL
AccessioniPrimary (citable) accession number: B7VSJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2009
Last sequence update: February 9, 2009
Last modified: March 31, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.