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B7VS66 (THIM_VIBSL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:VS_II1085
OrganismVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32)) [Complete proteome] [HAMAP]
Taxonomic identifier575788 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence caution

The sequence CAV26969.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383911

Sites

Binding site451Substrate; via amide nitrogen By similarity
Binding site1211ATP By similarity
Binding site1671ATP By similarity
Binding site1941Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B7VS66 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 7B93649505535272

FASTA26127,369
        10         20         30         40         50         60 
MLTEQIIQSL RAVREQKPLV VNITNYVVMN NTANALLAIG ASPIMAHSKQ ELAEMMSFSG 

        70         80         90        100        110        120 
ALVINIGTLD SVWTPRMCFA VEQANANNKV VVLDPVGCGA STLRTETSRE IARLADKLII 

       130        140        150        160        170        180 
RGNASEIIAL AGEQAQSKGV DALDSSDAAL GAAQCLVAEY GANVVISGET DYVVTKDSVV 

       190        200        210        220        230        240 
TLNNGHPMMP YVTGMGCTLT ALTGAFAAVG DESGLAAAAV LGVVGEISAE SSRGPGSLQM 

       250        260 
NLLDELYQLD EETLIQRLKV Q 

« Hide

References

[1]"Vibrio splendidus str. LGP32 complete genome."
Mazel D., Le Roux F.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LGP32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM954973 Genomic DNA. Translation: CAV26969.1. Different initiation.
RefSeqYP_002395664.1. NC_011744.2.

3D structure databases

ProteinModelPortalB7VS66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING575788.VS_II1085.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAV26969; CAV26969; VS_II1085.
GeneID7138371.
KEGGvsp:VS_II1085.
PATRIC20149951. VBIVibSpl48387_1025.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycVSPL575788:GH64-4163-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_VIBSL
AccessionPrimary (citable) accession number: B7VS66
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways