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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Vibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi281Magnesium or manganese 1UniRule annotation1
Metal bindingi294Magnesium or manganese 1UniRule annotation1
Metal bindingi294Magnesium or manganese 2UniRule annotation1
Metal bindingi296Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 206ATPUniRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:VS_II0746
OrganismiVibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000009100 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001897541 – 331D-alanine--D-alanine ligaseAdd BLAST331

Proteomic databases

PRIDEiB7VRZ7

Interactioni

Protein-protein interaction databases

STRINGi575788.VS_II0746

Structurei

3D structure databases

ProteinModelPortaliB7VRZ7
SMRiB7VRZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 327ATP-graspUniRule annotationAdd BLAST207

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011592
KOiK01921
OMAiRCDFFVI
OrthoDBiPOG091H06GK

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B7VRZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTNILLLC GGGSSEHEVS IVSANYLFEQ LNSVTDFNVV RVEIKNEGWC
60 70 80 90 100
LDSGELVYLD INDQTLRGDN LESKVDFIVP CIHGFPGETG DIQSLFEMAK
110 120 130 140 150
IPYLGCGSEA SNNSFNKITS KLWYDALGIP NTPYLFLSDN TEQAHAQATQ
160 170 180 190 200
AFESWGKVFV KAARQGSSVG CYQVNQVEEL SEAINKAFTF SDQVLIEKSV
210 220 230 240 250
VPRELEVAAY EIDGELQISK PGEVIAPNGA FYSYEEKYSA DSHSITEVEA
260 270 280 290 300
TNLTDEQREL IADSARKVFT QMKLRHLSRI DFFLTQDNEI YLNEVNTFPG
310 320 330
MTPISMFPKM VEHDGHKFSQ FLENCVRTSI S
Length:331
Mass (Da):37,013
Last modified:February 10, 2009 - v1
Checksum:iE1093FE85B030404
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954973 Genomic DNA Translation: CAV26458.1
RefSeqiWP_012600637.1, NC_011744.2

Genome annotation databases

EnsemblBacteriaiCAV26458; CAV26458; VS_II0746
GeneIDi7138038
KEGGivsp:VS_II0746
PATRICifig|575788.5.peg.704

Similar proteinsi

Entry informationi

Entry nameiDDL_VIBTL
AccessioniPrimary (citable) accession number: B7VRZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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