B7VQ44 (ADD_VIBSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosine deaminase
EC=3.5.4.4

Alternative name(s):
Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	VS_II0073

Organism

Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32)) [Complete proteome] [HAMAP]

Taxonomic identifier

575788 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Adenosine deaminase HAMAP MF_00540		PRO_1000146579
Sites
	Active site	199	1	Proton donor By similarity
	Metal binding	12	1	Zinc; catalytic By similarity
	Metal binding	14	1	Zinc; catalytic By similarity
	Metal binding	196	1	Zinc; catalytic By similarity
	Metal binding	277	1	Zinc; catalytic By similarity
	Binding site	14	1	Substrate By similarity
	Binding site	16	1	Substrate By similarity
	Binding site	169	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity
	Site	220	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7VQ44 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 91E9BFCF14BC4C7D	FASTA	332	37,431
	10 20 30 40 50 60 MDFLALPKID LHCHLDGSVR PDTIIDLAKQ YNIELPEDRD AVVQSLTVPE DCKNLDEYLA 70 80 90 100 110 120 CFSLPLQVMQ TEEAIERISF ELYEDAALEN VKYLEVRFAP ILHVNKGLSL DTIIASAVKG 130 140 150 160 170 180 MKRAEEKYDI KGNYIMSVLR MFPKDSIKDV IDAGQPYLGK GVVAFDIAGG EKPGFCAEFP 190 200 210 220 230 240 EYTQYALEKG YRITVHAGEQ WHGQNVYDAV TMLDAERIGH GVHIQGNEDA YNIVKEKQVA 250 260 270 280 290 300 LETCPTSNVQ TKCIHQFSDH PIAEFKKDGI VVTINTDNRT VSNTTMTNEV KRVCETFGLT 310 320 330 KEDYVEIYKY SVESAFASDE VKQHLMGFVE QI

References

[1]	"Vibrio splendidus str. LGP32 complete genome." Mazel D., Le Roux F. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LGP32.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM954973 Genomic DNA. Translation: CAV25306.1.
RefSeq	YP_002394676.1. NC_011744.2.
3D structure databases
ProteinModelPortal	B7VQ44.
ModBase	Search...
Protein-protein interaction databases
STRING	B7VQ44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7137386.
GenomeReviews	Gene locus VS_II0073 in contig FM954973_GR.
KEGG	vsp:VS_II0073.
PATRIC	20148020. VBIVibSpl48387_0071.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	CKKYQQQ.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_VIBSL

Accession

Primary (citable) accession number: B7VQ44

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program