B7VQ29 (B7VQ29_VIBSL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Choline dehydrogenase HAMAP MF_00750
Short name=CDH HAMAP MF_00750
Short name=CHD HAMAP MF_00750
EC=1.1.99.1 HAMAP MF_00750

Gene names

Name:	betA HAMAP MF_00750
Ordered Locus Names:	VS_II0058

Organism

Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32)) [Complete proteome] [HAMAP]

Taxonomic identifier

575788 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750 SAAS SAAS007867
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750 RuleBase RU003969 SAAS SAAS007867
Cofactor	FAD By similarity. HAMAP MF_00750 SAAS SAAS007867 RuleBase RU003968
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750 RuleBase RU003969 SAAS SAAS007867
Sequence similarities	Belongs to the GMC oxidoreductase family. HAMAP MF_00750 RuleBase RU003968

Ontologies

Keywords
Ligand	FAD HAMAP MF_00750 SAAS SAAS011533 Flavoprotein HAMAP MF_00750 SAAS SAAS011533 RuleBase RU003968
Molecular function	Oxidoreductase HAMAP MF_00750 SAAS SAAS007867
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	6 – 35	30	FAD By similarity HAMAP MF_00750
Sites
	Active site	478	1	By similarity HAMAP MF_00750

Sequences

	Sequence		Length	Mass (Da)
	B7VQ29 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 7094E9CD1AD25CEB	FASTA	570	62,887
	10 20 30 40 50 60 MEQRYDYIIV GAGSAGCVLA DRLTESGEHS VLLLEAGGTD KSIFIQMPTA LSYPMNTEKY 70 80 90 100 110 120 AWQFETEKEP GLDGRELHCP RGKVLGGSSS INGMVYVRGH ACDFDQWEEE GAAGWNYQAC 130 140 150 160 170 180 LPYFRRAESW NKGGDEYRGD NGPVGTCNGN DMELNPLYQA FIDAGKDAGY PETNDYNGYQ 190 200 210 220 230 240 QEGFGTMHMT VDKGVRASTS NAYLRRALKR SNLTLKKGIV ARRFLLEAQD SNGQSGLKAV 250 260 270 280 290 300 GVEFEKSGNT QVAVANKEVI SSAGSIGSVQ LLQLSGIGPK AVLEKAGVEL KHELIGVGEN 310 320 330 340 350 360 LQDHLEVYFQ YHCNEPITLN SKLGLVSKGM IGAEWILTRK GLGATNHFES CAFIRSRKGL 370 380 390 400 410 420 KWPNIQYHFL PAAMRYDGQA AFDGHGFQVH VGPNKPESRG TVAITSADPH AKPEIIFNYI 430 440 450 460 470 480 STEQDRQDWR DCIRLTREIL SQPAMDVYRG EEIQPGLSVT SDEAIDEWVK QNVESAYHPS 490 500 510 520 530 540 CGCKMGADDD PMAVLDEECR VRGIDNLRVV DSSVFPVIPN GNLNAPTIMV AERASDLILG 550 560 570 KPVLKEQNVP VWIAPEWEET QRINKPVREA

References

[1]	"Vibrio splendidus str. LGP32 complete genome." Mazel D., Le Roux F. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM954973 Genomic DNA. Translation: CAV25279.1.
RefSeq	YP_002394661.1. NC_011744.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B7VQ29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7137371.
GenomeReviews	Gene locus VS_II0058 in contig FM954973_GR.
KEGG	vsp:VS_II0058.
PATRIC	20147988. VBIVibSpl48387_0055.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734713.
OMA	HMTVKNG.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7VQ29_VIBSL

Accession

Primary (citable) accession number: B7VQ29

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)