Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7VQ28

- BETB_VIBTL

UniProt

B7VQ28 - BETB_VIBTL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Vibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K(+)UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1UniRule annotation
Metal bindingi24 – 241Potassium 1; via carbonyl oxygenUniRule annotation
Metal bindingi90 – 901Potassium 1UniRule annotation
Active sitei159 – 1591Charge relay systemUniRule annotation
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei247 – 2471Proton acceptorUniRule annotation
Binding sitei281 – 2811NAD/NADPUniRule annotation
Binding sitei382 – 3821NAD/NADPUniRule annotation
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei459 – 4591Charge relay systemUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciVSPL575788:GH64-3143-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:VS_II0057
OrganismiVibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000148559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi575788.VS_II0057.

Structurei

3D structure databases

ProteinModelPortaliB7VQ28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiRANDTTM.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7VQ28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEMNSLYIDG KAVDATSGET FVSINPANGE PIATLGQASS ADVENAIESA
60 70 80 90 100
KRGFAVWSAM TAVERSRILL KAVEILRARN NDLANLEVVD TGKPLQEAIE
110 120 130 140 150
VDVASGADVI EYFAGLAPTL QGDQQPLSDT QFFYTRREPL GICAGIGAWN
160 170 180 190 200
YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIFT EAGLPDGVFN
210 220 230 240 250
VVQGDYRVGQ MLTAHPDIAK VSFTGETGTG KAVMSDSAKT LKSVTMELGG
260 270 280 290 300
KSPMIIFDDA KLDDAVSASM VANFYTQGEV CTNGTRVYVH ESIYNDFIDQ
310 320 330 340 350
LKTRTEKLII GNPMDMETQI GALISKEHLS KVLEAIELAK QSGATLLTGG
360 370 380 390 400
YQVTDNGLAN GNFVIPTVFT DCHDDMPHVQ QEIFGPVMSV LKFTDEDDVI
410 420 430 440 450
RRANDTQYGL AAGVFTQNLS RAHRVIHQMQ AGICWVNTWG DSPAEMPVGG
460 470 480
YKLSGVGREN GPETLLHYTQ TKSILIELGD YASPYA
Length:486
Mass (Da):52,422
Last modified:February 10, 2009 - v1
Checksum:iBA07EA9F596B9090
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954973 Genomic DNA. Translation: CAV25277.1.
RefSeqiWP_012600069.1. NC_011744.2.
YP_002394660.1. NC_011744.2.

Genome annotation databases

EnsemblBacteriaiCAV25277; CAV25277; VS_II0057.
GeneIDi7137370.
KEGGivsp:VS_II0057.
PATRICi20147986. VBIVibSpl48387_0054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954973 Genomic DNA. Translation: CAV25277.1 .
RefSeqi WP_012600069.1. NC_011744.2.
YP_002394660.1. NC_011744.2.

3D structure databases

ProteinModelPortali B7VQ28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 575788.VS_II0057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV25277 ; CAV25277 ; VS_II0057 .
GeneIDi 7137370.
KEGGi vsp:VS_II0057.
PATRICi 20147986. VBIVibSpl48387_0054.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi RANDTTM.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci VSPL575788:GH64-3143-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiBETB_VIBTL
AccessioniPrimary (citable) accession number: B7VQ28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3