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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Vibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K(+)UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathway:ibetaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1UniRule annotation
Metal bindingi24 – 241Potassium 1; via carbonyl oxygenUniRule annotation
Metal bindingi90 – 901Potassium 1UniRule annotation
Active sitei159 – 1591Charge relay systemUniRule annotation
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei247 – 2471Proton acceptorUniRule annotation
Binding sitei281 – 2811NAD/NADPUniRule annotation
Binding sitei382 – 3821NAD/NADPUniRule annotation
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei459 – 4591Charge relay systemUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciVSPL575788:GH64-3143-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:VS_II0057
OrganismiVibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000148559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi575788.VS_II0057.

Structurei

3D structure databases

ProteinModelPortaliB7VQ28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7VQ28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMNSLYIDG KAVDATSGET FVSINPANGE PIATLGQASS ADVENAIESA
60 70 80 90 100
KRGFAVWSAM TAVERSRILL KAVEILRARN NDLANLEVVD TGKPLQEAIE
110 120 130 140 150
VDVASGADVI EYFAGLAPTL QGDQQPLSDT QFFYTRREPL GICAGIGAWN
160 170 180 190 200
YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIFT EAGLPDGVFN
210 220 230 240 250
VVQGDYRVGQ MLTAHPDIAK VSFTGETGTG KAVMSDSAKT LKSVTMELGG
260 270 280 290 300
KSPMIIFDDA KLDDAVSASM VANFYTQGEV CTNGTRVYVH ESIYNDFIDQ
310 320 330 340 350
LKTRTEKLII GNPMDMETQI GALISKEHLS KVLEAIELAK QSGATLLTGG
360 370 380 390 400
YQVTDNGLAN GNFVIPTVFT DCHDDMPHVQ QEIFGPVMSV LKFTDEDDVI
410 420 430 440 450
RRANDTQYGL AAGVFTQNLS RAHRVIHQMQ AGICWVNTWG DSPAEMPVGG
460 470 480
YKLSGVGREN GPETLLHYTQ TKSILIELGD YASPYA
Length:486
Mass (Da):52,422
Last modified:February 10, 2009 - v1
Checksum:iBA07EA9F596B9090
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954973 Genomic DNA. Translation: CAV25277.1.
RefSeqiWP_012600069.1. NC_011744.2.

Genome annotation databases

EnsemblBacteriaiCAV25277; CAV25277; VS_II0057.
GeneIDi7137370.
KEGGivsp:VS_II0057.
PATRICi20147986. VBIVibSpl48387_0054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954973 Genomic DNA. Translation: CAV25277.1.
RefSeqiWP_012600069.1. NC_011744.2.

3D structure databases

ProteinModelPortaliB7VQ28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi575788.VS_II0057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAV25277; CAV25277; VS_II0057.
GeneIDi7137370.
KEGGivsp:VS_II0057.
PATRICi20147986. VBIVibSpl48387_0054.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.
BioCyciVSPL575788:GH64-3143-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiBETB_VIBTL
AccessioniPrimary (citable) accession number: B7VQ28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.