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B7VQ28

- BETB_VIBSL

UniProt

B7VQ28 - BETB_VIBSL

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Potassium 1UniRule annotation
    Metal bindingi24 – 241Potassium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi90 – 901Potassium 1UniRule annotation
    Active sitei159 – 1591Charge relay systemUniRule annotation
    Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei247 – 2471Proton acceptorUniRule annotation
    Binding sitei281 – 2811NAD/NADPUniRule annotation
    Binding sitei382 – 3821NAD/NADPUniRule annotation
    Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei459 – 4591Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
    Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
    Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciVSPL575788:GH64-3143-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:VS_II0057
    OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
    Taxonomic identifieri575788 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000009100: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000148559Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi575788.VS_II0057.

    Structurei

    3D structure databases

    ProteinModelPortaliB7VQ28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiRANDTTM.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7VQ28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEMNSLYIDG KAVDATSGET FVSINPANGE PIATLGQASS ADVENAIESA    50
    KRGFAVWSAM TAVERSRILL KAVEILRARN NDLANLEVVD TGKPLQEAIE 100
    VDVASGADVI EYFAGLAPTL QGDQQPLSDT QFFYTRREPL GICAGIGAWN 150
    YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIFT EAGLPDGVFN 200
    VVQGDYRVGQ MLTAHPDIAK VSFTGETGTG KAVMSDSAKT LKSVTMELGG 250
    KSPMIIFDDA KLDDAVSASM VANFYTQGEV CTNGTRVYVH ESIYNDFIDQ 300
    LKTRTEKLII GNPMDMETQI GALISKEHLS KVLEAIELAK QSGATLLTGG 350
    YQVTDNGLAN GNFVIPTVFT DCHDDMPHVQ QEIFGPVMSV LKFTDEDDVI 400
    RRANDTQYGL AAGVFTQNLS RAHRVIHQMQ AGICWVNTWG DSPAEMPVGG 450
    YKLSGVGREN GPETLLHYTQ TKSILIELGD YASPYA 486
    Length:486
    Mass (Da):52,422
    Last modified:February 10, 2009 - v1
    Checksum:iBA07EA9F596B9090
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM954973 Genomic DNA. Translation: CAV25277.1.
    RefSeqiWP_012600069.1. NC_011744.2.
    YP_002394660.1. NC_011744.2.

    Genome annotation databases

    EnsemblBacteriaiCAV25277; CAV25277; VS_II0057.
    GeneIDi7137370.
    KEGGivsp:VS_II0057.
    PATRICi20147986. VBIVibSpl48387_0054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM954973 Genomic DNA. Translation: CAV25277.1 .
    RefSeqi WP_012600069.1. NC_011744.2.
    YP_002394660.1. NC_011744.2.

    3D structure databases

    ProteinModelPortali B7VQ28.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 575788.VS_II0057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAV25277 ; CAV25277 ; VS_II0057 .
    GeneIDi 7137370.
    KEGGi vsp:VS_II0057.
    PATRICi 20147986. VBIVibSpl48387_0054.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi RANDTTM.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci VSPL575788:GH64-3143-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vibrio splendidus str. LGP32 complete genome."
      Mazel D., Le Roux F.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LGP32.

    Entry informationi

    Entry nameiBETB_VIBSL
    AccessioniPrimary (citable) accession number: B7VQ28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3