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B7VMF0 (GPPA_VIBSL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:VS_3074
OrganismVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32)) [Complete proteome] [HAMAP]
Taxonomic identifier575788 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000185317

Sequences

Sequence LengthMass (Da)Tools
B7VMF0 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: AB91E78A3EF8B919

FASTA49754,928
        10         20         30         40         50         60 
MSQTVSPPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE NNALSTEAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLRDIPKEN IRIVGTATLR TAINVDIFLE KANQILGYDI NVISGEEEAA 

       130        140        150        160        170        180 
TIYKGVAHTS GGSGRRLVVD IGGASTEMII GEGFSAKALT SLKMGCVTWL ERHFKDRQLT 

       190        200        210        220        230        240 
ATNFNNAIEA AKSTLAPILD SYTDIGWDVC VGASGTVQAL QEIMLAQGMD EVITHAKLKR 

       250        260        270        280        290        300 
LQKQAMITER LEELEIEGLT LERALVFPSG LSILIAIFEL LEIDSMTLAG GALREGLAYE 

       310        320        330        340        350        360 
MVDEFRQEDI RARTIKSVQS RYQMDVSYSE QVAVVAQTLL EQAGAETWVS EPQAGVLLQT 

       370        380        390        400        410        420 
AAKLHEIGLT IDFKKGGEHS AYLLQNLDLP GFTRAQKHCL GELTRRYREQ LTSLPEQHAI 

       430        440        450        460        470        480 
SGTSSKRILR ILRLAILLTH RRNPALEPEF KLTTDDNNLT LTLSKQWLAD NPLTAAELEI 

       490 
ESNRQTDIGW PLNIECL 

« Hide

References

[1]"Vibrio splendidus str. LGP32 complete genome."
Mazel D., Le Roux F.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LGP32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM954972 Genomic DNA. Translation: CAV20341.1.
RefSeqYP_002418581.1. NC_011753.2.

3D structure databases

ProteinModelPortalB7VMF0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING575788.VS_3074.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAV20341; CAV20341; VS_3074.
GeneID7162527.
KEGGvsp:VS_3074.
PATRIC20156646. VBIVibSpl48387_4251.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAIGWDVCV.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycVSPL575788:GH64-3005-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_VIBSL
AccessionPrimary (citable) accession number: B7VMF0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways