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B7VMF0

- GPPA_VIBSL

UniProt

B7VMF0 - GPPA_VIBSL

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVSPL575788:GH64-3005-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:VS_3074
OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000185317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi575788.VS_3074.

Structurei

3D structure databases

ProteinModelPortaliB7VMF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7VMF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQTVSPPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE
60 70 80 90 100
NNALSTEAMQ RGWDCLSLFA ERLRDIPKEN IRIVGTATLR TAINVDIFLE
110 120 130 140 150
KANQILGYDI NVISGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTEMII
160 170 180 190 200
GEGFSAKALT SLKMGCVTWL ERHFKDRQLT ATNFNNAIEA AKSTLAPILD
210 220 230 240 250
SYTDIGWDVC VGASGTVQAL QEIMLAQGMD EVITHAKLKR LQKQAMITER
260 270 280 290 300
LEELEIEGLT LERALVFPSG LSILIAIFEL LEIDSMTLAG GALREGLAYE
310 320 330 340 350
MVDEFRQEDI RARTIKSVQS RYQMDVSYSE QVAVVAQTLL EQAGAETWVS
360 370 380 390 400
EPQAGVLLQT AAKLHEIGLT IDFKKGGEHS AYLLQNLDLP GFTRAQKHCL
410 420 430 440 450
GELTRRYREQ LTSLPEQHAI SGTSSKRILR ILRLAILLTH RRNPALEPEF
460 470 480 490
KLTTDDNNLT LTLSKQWLAD NPLTAAELEI ESNRQTDIGW PLNIECL
Length:497
Mass (Da):54,928
Last modified:February 10, 2009 - v1
Checksum:iAB91E78A3EF8B919
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV20341.1.
RefSeqiYP_002418581.1. NC_011753.2.

Genome annotation databases

EnsemblBacteriaiCAV20341; CAV20341; VS_3074.
GeneIDi7162527.
KEGGivsp:VS_3074.
PATRICi20156646. VBIVibSpl48387_4251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV20341.1 .
RefSeqi YP_002418581.1. NC_011753.2.

3D structure databases

ProteinModelPortali B7VMF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 575788.VS_3074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV20341 ; CAV20341 ; VS_3074 .
GeneIDi 7162527.
KEGGi vsp:VS_3074.
PATRICi 20156646. VBIVibSpl48387_4251.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VSPL575788:GH64-3005-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiGPPA_VIBSL
AccessioniPrimary (citable) accession number: B7VMF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 1, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3