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B7VMF0

- GPPA_VIBSL

UniProt

B7VMF0 - GPPA_VIBSL

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciVSPL575788:GH64-3005-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:VS_3074
    OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
    Taxonomic identifieri575788 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000009100: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000185317Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi575788.VS_3074.

    Structurei

    3D structure databases

    ProteinModelPortaliB7VMF0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiSYVHWAL.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7VMF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQTVSPPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
    NNALSTEAMQ RGWDCLSLFA ERLRDIPKEN IRIVGTATLR TAINVDIFLE 100
    KANQILGYDI NVISGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTEMII 150
    GEGFSAKALT SLKMGCVTWL ERHFKDRQLT ATNFNNAIEA AKSTLAPILD 200
    SYTDIGWDVC VGASGTVQAL QEIMLAQGMD EVITHAKLKR LQKQAMITER 250
    LEELEIEGLT LERALVFPSG LSILIAIFEL LEIDSMTLAG GALREGLAYE 300
    MVDEFRQEDI RARTIKSVQS RYQMDVSYSE QVAVVAQTLL EQAGAETWVS 350
    EPQAGVLLQT AAKLHEIGLT IDFKKGGEHS AYLLQNLDLP GFTRAQKHCL 400
    GELTRRYREQ LTSLPEQHAI SGTSSKRILR ILRLAILLTH RRNPALEPEF 450
    KLTTDDNNLT LTLSKQWLAD NPLTAAELEI ESNRQTDIGW PLNIECL 497
    Length:497
    Mass (Da):54,928
    Last modified:February 10, 2009 - v1
    Checksum:iAB91E78A3EF8B919
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM954972 Genomic DNA. Translation: CAV20341.1.
    RefSeqiYP_002418581.1. NC_011753.2.

    Genome annotation databases

    EnsemblBacteriaiCAV20341; CAV20341; VS_3074.
    GeneIDi7162527.
    KEGGivsp:VS_3074.
    PATRICi20156646. VBIVibSpl48387_4251.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM954972 Genomic DNA. Translation: CAV20341.1 .
    RefSeqi YP_002418581.1. NC_011753.2.

    3D structure databases

    ProteinModelPortali B7VMF0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 575788.VS_3074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAV20341 ; CAV20341 ; VS_3074 .
    GeneIDi 7162527.
    KEGGi vsp:VS_3074.
    PATRICi 20156646. VBIVibSpl48387_4251.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi SYVHWAL.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci VSPL575788:GH64-3005-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vibrio splendidus str. LGP32 complete genome."
      Mazel D., Le Roux F.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LGP32.

    Entry informationi

    Entry nameiGPPA_VIBSL
    AccessioniPrimary (citable) accession number: B7VMF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3